LIU, Guozhen

Associate Dean of Graduate School; Programme Coordinator of Undergraduate Programme in Biomedical Science and Engineering; Presidential Fellow
World's Top 2% Scientist

Professor

Education Background

PhD (University of New South Wales, Sydney, Australia)

BS（China University of Geosciences）

MS (Huhei Normal University)

Research Field
Biomedical Engineering, Biosensors, Microfluidic paper-based biochips, Flexible wearables, 3D printing, In vitro point-of-care diagnostics, Intelligent nanoparticles and medical devices
Email
liuguozhen@cuhk.edu.cn
Biography

Guozhen LIU is a Professor of Biomedical Engineering, the director of CUHK(SZ)-BoyaLife Joint Laboratory for Regenerative Medicine Engineering, and the founding chair of the Biomedical Engineering discipline at the School of Medicine, the Chinese University of Hong Kong, Shenzhen. Her scientific career is alternating between academia and industry. Currently she is leading a research team of Integrated Devices and Intelligent Diagnostics (ID2) focusing on interdisciplinary and translational research to develop cutting-edge technologies to diagnose, manage and prevent aging and chronic diseases such as diabetes, Parkinson's disease, osteoarthritis, et al. She was awarded a prestigious Australian Research Council Future Fellowship in 2016. In recognition of her novel technologies in monitoring of neuroinflammation towards next generation cancer immunotherapy, she received the 2020 Georgina Sweet Award for Women in Quantitative Biomedical Science. She won the 2022 President's Exemplary Teaching Award, 2023 Zhejiang Talent Award, et al. Prof. Liu is listed in the top 2% of scientists and the global scholars with academic influence. Prof. Liu is an inventor with many internationally registered patents. The patented technologies have attracted significant funding (over $10M) from government and industries, such as AstraZeneca. Prof. Liu is an Associate Editor of ACS Sensors, and in the editorial board for many journals (such as Sensors and Diagnostics, IEEE Sensors Journal).

In addition to her teaching and research experience in academia, Prof. Liu has extensive experience working with various industries. Through cooperation with international biotechnology companies, such as AstraZeneca, BioLegend, AgaMatrix, Nutromics, as well as many others, Prof. Liu has gained comprehensive expertise in development and production of medical devices. She was the R&D Manager, China, AgaMatrix Inc. making products for diabetes from 2011 to 2015. She is the co-founder of Bio-Sens Tech Pty Ltd, a Startup company in Sydney for non-invasive early diagnosis of diabetes.

Academic Publications

Webpage of the Project Group：

https://www.x-mol.com/groups/liu_guozhen

Selected peer-reviewed journal publications in last 5 years (*corresponding author; Google citations: https://scholar.google.com.au/citations?user=xms_zr0AAAAJ&hl=en)

  1. S. Tao, X. Han, D. Shi, T. Yu, Y. Long, S. Zou, S. Lu, L. Song*, Guozhen Liu*, Portable Device with Nicking Enzyme Enhanced Special RCA on μPADs toward Sensitive Detection of High-Risk HPV Infection, Analytical Chemistry, 2024, Article ASAP, https://doi.org/10.1021/acs.analchem.4c02070 (Front cover paper)
  2. D. Li, S. Zou, Z. Huang, C. Sun*, Guozhen Liu*, Isolation and quantification of L1CAM-positive extracellular vesicles on a chip as a potential biomarker for Parkinson's Disease, Journal of Extracellular Vesicles, 2024, 13, e12467. https://doi.org/10.1002/jev2.12467
  3. S. Zou, J. Li, S. Lu, D. Li, Y. Liu, W. Zhang, X. Cui, J.J. Gooding, K. Tian*, Guozhen Liu*, CRISPR-Cas12a immunosensing on glass fiber for point-of-care quantification of multiple inflammation biomarkers in osteoarthritis, Device, 2024, 100319, https://doi.org/10.1016/j.device.2024.100319
  4. Y. Long, S. Tao, D. Shi, X. Jiang, T. Yu, Y. Long, L. Song*, Guozhen Liu*, Special RCA based sensitive point-of-care detection of HPV mRNA for cervical cancer screening, Aggregate, 2024, e569.  https://doi.org/10.1002/agt2.569 (Front cover paper)
  5. Z. Bao, S. Lu, D. Zhang, G. Wang, X. Cui*, Guozhen Liu*, Wearable Microneedle Patch for Colorimetric Detection of Multiple Signature Biomarkers in vivo Toward Diabetic Diagnosis, Advanced Healthcare Materials, 2024, 2303511, https://doi.org/10.1002/adhm.202303511
  6. Z. Huang, M. Guan, Z. Bao, F. Dong, X. Cui, Guozhen Liu*, Ligand Mediation for Tunable and Oxide Suppressed Surface Gold-Decorated Liquid Metal Nanoparticles. Small, 2024, 20: 2470053. https://doi.org/10.1002/smll.202470053 (Front cover paper)
  7. W. Liu, S. Liu, K. Fan, Z. Li, Z. Guo, D. Cheng*, Guozhen Liu*, Machine-Learning-based Colorimetric Sensor on Smartphone for Salivary Uric Acid Detection, IEEE Sensors Journal, 2024, https://doi.org/10.1109/JSEN.2024.3404646
  8. R. Shi, L. Zhong, Guozhen Liu*, W. C. Mak*, CRISPR/Cas biosensing technology: From lab assays to integrated portable devices towards wearables, TrAC Trends in Analytical Chemistry, 2024, 117796. https://doi.org/10.1016/j.trac.2024.117796
  9. S. Liu, Y. Hou, Z. Li, C. Yang, Guozhen Liu*, μPADs on Centrifugal Microfluidic Discs for Rapid Sample-to-Answer Salivary Diagnostics, ACS Sensors, 2023, 8 (9), 3520-3529, https://dot.org/10.1021/acssensors.3c01093
  10. K. Fan, J. Zeng, C. Yang, G. Wang, K. Lian, X. Zhou, Y. Deng, Guozhen Liu*, Digital Quantification Method for Sensitive Point-of-Care Detection of Salivary Uric Acid Using Smartphone-Assisted μPADs, ACS Sensors, 2022, 7, 2049−2057, https://doi.org/10.1021/acssensors.2c00854
  11. Z. Huang, S. Zou, Guozhen Liu*, Surface Modification of Liquid Metal with p-Aniline Derivatives toward Bioapplications: Biosensing as an example, ACS Applied Materials & Interfaces, 2022, 14 (51), 56429-56439, https://doi.org/10.1021/acsami.2c10139
  12. D. Shi, X. Wu, Y. Jian, J. Wang, C. Huang, S. Mo, Y. Li, F. Li, C. Zhang, D. Zhang, H. Zhang, H. Huang, X. Chen, Y. A. Wang, C. Lin, Guozhen Liu*, L. Song*, W. Liao*, USP14 Promotes Tryptophan Metabolism and Immune Suppression by Stabilizing IDO1 in Colorectal Cancer, Nature Communications, 2022, 13(5644), 1-8, https://doi.org/10.1038/s41467-022-33285-x
  13. S. Liu, Z. Shen, L. Deng, Guozhen Liu*, Smartphone Assisted Portable Biochip for Non-Invasive Simultaneous Monitoring of Glucose and Insulin Towards Precise Diagnosis of Prediabetes/Diabetes, Biosensors and Bioelectronics, 2022, 114251. https://doi.org/10.1016/j.bios.2022.114251 
  14. J. Zhuang, Z. Zhao, K. Lian, L. Yin, S. Man,* Guozhen Liu,* L. Ma*, SERS-based CRISPR/Cas assay on microfluidic paper analytical devices for supersensitive detection of pathogenic bacteria, Biosensors and Bioelectronics, 2022, 114167. https://doi.org/10.1016/j.bios.2022.114167
  15. M. Baharfar, M. Mayyas,* M. Rahbar, F. Allioux, J. Tang, Y. Wang, Z. Cao, F. Centurion, R. Jalili, Guozhen Liu,* K. Kalantar-Zadeh*, Exploring Interfacial Graphene Oxide Reduction by Liquid Metals: Application in Selective Biosensing, ACS Nano, 2021, 12, 19661–19671. https://doi.org/10.1021/acsnano.1c06973 
  16. X. Lin, G. Wang, L. Ma, Guozhen Liu*, Study on Factors Affecting the Performance of a CRISPR/Cas-Assisted New Immunoassay: Detection of Salivary Insulin as an Example, Frontiers in Bioengineering and Biotechnology, 2021, 9, 752514, 1-12. https://doi.org/10.3389/fbioe.2021.752514 
  17. Z. Shen, S. Ni, W. Yang, W. Sun*, G. Yang, Guozhen Liu*, Redox probes tagged electrochemical aptasensing device for simultaneous detection of multiple cytokines in real time, Sensors and Actuators B: Chemical, 2021, 336, 129747, 1-10. https://doi.org/10.1016/j.snb.2021.129747 
  18. C. Liu, D. Chu, K. Kalantar-Zadeh, J. George, H. Young*, Guozhen Liu*, Cytokines: Clinical significance and quantification, Advanced Science, 2021, 8, 2004433. https://doi.org/10.1002/advs.202004433
  19. M. Baharfar, M. Rahbar, M. Tajiki, Guozhen Liu*, Engineering Strategies for Enhancing the Performance of Electrochemical Paper-Based Analytical Devices, Biosensors and Bioelectronics, 2020, 167, 112506. https://doi.org/10.1016/j.bios.2020.112506
  20. M. Frank, M. Baratta, K. Zhang, I. Fallon, M. Pearson, Guozhen Liu, M. Hutchinson, L. Watkins, E. Goldys, S. Maier*, Acute stress induces the rapid and transient induction of caspase-1, gasdermin D and release of constitutive IL-1b protein in dorsal hippocampus, Brain, Behaviour, and Immunity, 2020, 90, 70-80. https://doi.org/10.1016/j.bbi.2020.07.042
  21. A. Arman, F. Deng, E. M. Goldys, Guozhen Liu*, M. R. Hutchinson*, In vivo intrathecal IL-1β quantification in rats: monitoring the molecular signals of neuropathic pain, Brain, Behaviour, and Immunity, 2020, 88, 442-450. https://doi.org/10.1016/j.bbi.2020.04.009
  22. Z. Shen, J. Huang, H. Wei, H. Niu, B. Li, R. Li, Guozhen Liu*, Validation of an in vivo electrochemical immunosensing platform for simultaneous detection of multiple cytokines in Parkinson’s Disease mice model, Bioelectrochemistry, 2020, 134, 107532. https://doi.org/10.1016/j.bioelechem.2020.107532
  23. Z. Luo, T. Lv, K. Zhu, Y. Li, L. Wang, J. J. Gooding, Guozhen Liu*, B. Liu*, Paper-based Ratiometric Fluorescence Analytical Devices towards Point-of-Care Testing of Human Serum Albumin, Angew. Chem. Int. Ed., 2020, 59, 1-7. https://doi.org/10.1002/anie.201915046
  24. C. Cao, R. Jin, H. Wei, Z. Liu, S. Ni, G-J Liu, H. A. Young, X. Chen*, Guozhen Liu*, Adaptive in vivo device for theranostics of inflammation: real-time monitoring of interferon-gamma and aspirin, Acta Biomaterialia, 2020, 101, 372-383. https://doi.org/10.1016/j.actbio.2019.10.021
  25. Guozhen Liu*, C. Bursill, S. P. Cartland, A. G. Anwer, L. M. Parker, K. Zhang, S. Feng, M. He, D. W. Inglis, M. M. Kavurma, M.R. Hutchinson, E. M Goldys*, A nanoparticle-based affinity sensor that identifier and select highly cytokine-secreting cells, iScience, 2019, 20, 137-147. https://doi.org/10.1016/j.isci.2019.09.019
  26. F. Deng, E.M. Goldys, Guozhen Liu*, Molecularly imprinted polymer-based reusable biosensing device on stainless steel for spatially localized detection of cytokine IL-1β, Sensors and Actuators B: Chemical, 2019, 292, 277-283. https://doi.org/10.1016/j.snb.2019.04.142
  27. Y. Li, S. Li, J. Wang*, Guozhen Liu*, CRISPR/Cas systems towards next generation biosensing, Trends in Biotechnology, 2019, 37 (7), 730-743. https://doi.org/10.1016/j.tibtech.2018.12.005, 
  28. C. Cao. R. Jin, H. Wei, W. Yang, E. Goldys, M. R. Hutchinson, S. Liu, X. Chen*, G. Yang, Guozhen Liu*, Graphene Oxide Based Recyclable In vivo Device for Amperometric Monitoring of Interferon-γ in Inflammatory Mice, ACS Appl. Mater. Interfaces, 2018, 10 (39), 33078-33087. https://doi.org/10.1021/acsami.8b13518
  29. H. Wei, S. Ni, C. Cao, G. Yang, Guozhen Liu*, Graphene oxides signal reporters based multifunctional immunosensing platform for amperometric profiling of multiple cytokines in serum, ACS Sensors, 2018, 3(8), 1553-1561. https://doi.org/10.1021/acssensors.8b00365
  30. K. Zhang, M.V. Baratta, Guozhen Liu*, M.G. Frank, N.R. Leslie, L.R. Watkins, S.F. Maier, M.R. Hutchinson, E.M. Goldys*, A novel platform for in vivo detection of cytokine release within discrete brain regions, Brain, Behaviour, and Immunity, 2018, S0889-159(18), 30130-30132. https://doi.org/101016/j.bbi.2018.04.011