刘国珍

研究生院副院长、生物医学工程本科专业负责人、校长学者
全球前2%顶尖科学家

教授

教育背景

博士（新南威尔士大学）

硕士（中国地质大学）

学士（湖北师范大学）

研究领域
生物医学工程、生物传感器、微流控生物芯片、柔性可穿戴器件、3D打印、体外诊断、智能纳米颗粒及医疗器械
电子邮件
liuguozhen@cuhk.edu.cn
个人简介

刘国珍是香港中文大学（深圳）医学院教授、研究生院副院长、港中深-博雅生命再生医学工程联合实验室主任、医学院生物医学工程学科创始人、校长模范教学奖获得者。刘国珍教授带领的集成器件和智能诊断（Integrated Devices and Intelligent Diagnostics，ID2）研究团队主要从事生物医学工程交叉学科和可转化生物技术的研究，致力于开发前沿的生物传感器技术、体外诊断技术、微流控芯片技术及医疗器械来精准诊疗、管理及预防一些慢性疾病如糖尿病、神经退行性疾病、心血管疾病及衰老等。2016年，刘教授获得澳大利亚基金委授予的未来学者（ARC Future Fellow）荣誉称号。凭借在神经炎症精准诊疗的突出贡献，刘教授获得2020年度乔治娜斯威特定量生物医学女科学家奖，她是第一个荣此奖项的华人女科学家。此外，刘教授还入选了全球2%顶尖科学家及全球学者终身学术影响力排行榜。目前，刘教授担任传感器领域国际知名期刊ACS Sensors副主编，同时她还是多个国际期刊（Sensors & Diagnostics, IEEE Sensors Journal等）的编委。
她曾担任美国医疗器械公司AgaMatrix Inc. 研发部经理（中国）（2011-2015），主要负责血糖试纸条的配方和生产。她是澳大利亚初创公司Bio-Sens Tech Pty Ltd的联合创始人。通过与国内外生物科技公司（如AstraZeneca，BioLegend，AgaMatrix，Regeneus，博雅生命等）的合作，累积了丰富的产学研经历，拥有多项国际专利。

学术著作

课题组网页：

https://www.x-mol.com/groups/liu_guozhen

Selected peer-reviewed journal publications in last 5 years (*corresponding author; Google citations: https://scholar.google.com.au/citations?user=xms_zr0AAAAJ&hl=en)

Topics on Microfluidic biochips for point-of-care diagnostics

  1. S. Tao, X. Han, D. Shi, T. Yu, Y. Long, S. Zou, S. Lu, L. Song*, Guozhen Liu*, Portable Device with Nicking Enzyme Enhanced Special RCA on μPADs toward Sensitive Detection of High-Risk HPV Infection, Analytical Chemistry, 2024, Article ASAP, https://doi.org/10.1021/acs.analchem.4c02070
  2. D. Li, S. Zou, Z. Huang, C. Sun*, Guozhen Liu*, Isolation and quantification of L1CAM-positive extracellular vesicles on a chip as a potential biomarker for Parkinson's Disease, Journal of Extracellular Vesicles, 2024, 13, e12467. https://doi.org/10.1002/jev2.12467
  3. S. Liu, Y. Hou, Z. Li, C. Yang, Guozhen Liu*, μPADs on Centrifugal Microfluidic Discs for Rapid Sample-to-Answer Salivary Diagnostics, ACS Sensors, 2023, 8 (9), 3520-3529, DOI: 10.1021/acssensors.3c01093
  4. K. Fan, J. Zeng, C. Yang, G. Wang, K. Lian, X. Zhou, Y. Deng, Guozhen Liu*, Digital Quantification Method for Sensitive Point-of-Care Detection of Salivary Uric Acid Using Smartphone-Assisted μPADs, ACS Sensors, 2022, 7, 2049−2057, https://doi.org/10.1021/acssensors.2c00854
  5. Y. Liu, S. Lu, Z. Zhang, Z. Yang, X. Cui, Guozhen Liu*, Printable biosensors towards next-generation point-of-care testing: paper substrate as an example. Lab on a Chip, 2023, 1-25, https://doi.org/10.1039/D3LC00038A
  6. Z. Luo, T. Lv, K. Zhu, Y. Li, L. Wang, J. J. Gooding, Guozhen Liu*, B. Liu*, Paper-based Ratiometric Fluorescence Analytical Devices towards Point-of-Care Testing of Human Serum Albumin, Angew. Chem. Int. Ed., 2020, 59, 1-7, https://doi.org/10.1002/anie.201915046

Topics on CRISPR/Cas based biosensing technologies

  1. S. Zou, J. Li, S. Lu, D. Li, Y. Liu, W. Zhang, X. Cui, J.J. Gooding, K. Tian*, Guozhen Liu*, CRISPR-Cas12a immunosensing on glass fiber for point-of-care quantification of multiple inflammation biomarkers in osteoarthritis, Device, 2024, 100319, https://doi.org/10.1016/j.device.2024.100319
  2. Y. Long, S. Tao, D. Shi, X. Jiang, T. Yu, Y. Long, L. Song, Guozhen Liu*, Special RCA based sensitive point-of-care detection of HPV mRNA for cervical cancer screening, Aggregate, 2024, e569.  https://doi.org/10.1002/agt2.569
  3. J. Zhuang, Z. Zhao, K. Lian, L. Yin, J. Wang, S. Man, Guozhen Liu*, L. Ma*, SERS-based CRISPR/Cas assay on microfluidic paper analytical devices for supersensitive detection of pathogenic bacteria in foods, Biosensors and Bioelectronics, 2022, 207, 114167, https://doi.org/10.1016/j.bios.2022.114167
  4. X. Lin, G. Wang, L. Ma, Guozhen Liu*, Study on Factors Affecting the Performance of a CRISPR/Cas-Assisted New Immunoassay: Detection of Salivary Insulin as an Example, Frontiers in Bioengineering and Biotechnology, 2021, 9:752514, https://doi.org/10.3389/fbioe.2021.752514
  5. Y. Dai, Y. Wu, Guozhen Liu, J. J. Gooding, CRISPR mediated biosensing toward understanding cellular biology and point-of-care diagnosis, Angew. Chem. Int. Ed., 2020, 132, 20938-20950, https://doi.org/10.1002/ange.202005398
  6. Y. Li, S. Li, J. Wang, Guozhen Liu*, CRISPR/Cas systems towards next generation biosensing, Trends in Biotechnology, 2019, 37 (7), 730-743, https://doi.org/10.1016/j.tibtech.2018.12.005

Topics on Wearable biosensing devices

  1. Z. Bao, S. Lu, D. Zhang, G. Wang, X. Cui*, Guozhen Liu*, Wearable Microneedle Patch for Colorimetric Detection of Multiple Signature Biomarkers in vivo Toward Diabetic Diagnosis, Advanced Healthcare Materialsm, 2024, 2303511, https://doi.org/10.1002/adhm.202303511
  2. R. Shi, L. Zhong, Guozhen Liu*, W. C. Mak*, CRISPR/Cas biosensing technology: From lab assays to integrated portable devices towards wearables, TrAC Trends in Analytical Chemistry, 2024, 117796. https://doi.org/10.1016/j.trac.2024.117796
  3. S. Liu, Z. Shen, L. Deng, Guozhen Liu*, Smartphone assisted portable biochip for non-invasive simultaneous monitoring of glucose and insulin towards precise diagnosis of prediabetes/diabetes,  Biosensors and Bioelectronics, 2022, 209, 114251, https://doi.org/10.1016/j.bios.2022.114251
  4. M. R. Benzigar, V. D.B.C Dasireddy, X. Guan, T. Wu, G. Liu*, Advances on emerging materials for flexible supercapacitors: current trends and beyond, Adv. Funct. Mater., 2020, 2002993, 1-41, https://doi.org/10.1002/adfm.202002993
  5. L. Qiao, M. Benzigar, A. Subramony, N. Lovell, G. Liu*, Advances in Sweat Wearables: Sample Extraction, Real-Time Biosensing, and Flexible Platforms, ACS Appl. Mater. Interfaces, 2020, 12, 30, 34337-34361, https://doi.org/10.1021/acsami.0c07614
  6. Guozhen Liu*, C. Cao, H. Wei, S. Feng, S. Ni, On-Chip Structure-Switching Aptamer Modified Magnetic Nanobeads for Continuous Monitoring of Interferon-gamma Ex Vivo, Microsys. Nanoeng., 2019, 5:35, 1-11, https://doi.org/10.1038/s41378-019-0074-1

Topics on In vivo biosensing devices for monitoring of cytokines

  1. C. Liu, D. Chu, K. Kalantar-Zadeh, J. George, H. A. Young*, Guozhen Liu*, Cytokines: From Clinical Significance to Quantification. Advanced Science, 2021, 8, 2004433. https://doi.org/10.1002/advs.202004433  
  2. C. Cao, R. Jin, H. Wei, Z. Liu, S. Ni, G-J Liu, H. A. Young, X. Chen*, Guozhen Liu*, Adaptive in vivo device for theranostics of inflammation: real-time monitoring of interferon-gamma and aspirin, Acta Biomaterialia, 2020, 101, 372-383, https://doi.org/10.1016/j.actbio.2019.10.021
  3. Z. Shen, J. Huang, H. Wei, H. Niu, B. Li, R. Li, Guozhen Liu*, Validation of an in vivo electrochemical immunosensing platform for simultaneous detection of multiple cytokines in Parkinson’s Disease mice model, Bioelectrochemistry, 2020, 134, 107532, https://doi.org/10.1016/j.bioelechem.2020.107532
  4. A. Arman, F. Deng, E. M. Goldys, Guozhen Liu*, M. R. Hutchinson*, In vivo intrathecal IL-1β quantification in rats: monitoring the molecular signals of neuropathic pain, Brain Behav. Immu., 2020, 88, 442-450, https://doi.org/10.1016/j.bbi.2020.04.009
  5. C. Cao. R. Jin, H. Wei, W. Yang, E. Goldys, M. R. Hutchinson, S. Liu, X. Chen*, G. Yang, Guozhen Liu*, Graphene Oxide Based Recyclable In vivo Device for Amperometric Monitoring of Interferon-γ in Inflammatory Mice, ACS Appl. Mater. Interfaces, 2018, 10 (39), 33078–33087, https://doi.org/10.1021/acsami.8b13518
  6. H. Wei, S.N. Ni, C.M. Cao, G. F. Yang, Guozhen Liu*, Graphene oxides signal reporters based multifunctional immunosensing platform for amperometric profiling of multiple cytokines in serum, ACS Sens., 2018, 3(8), 1553-1561, https://doi.org/10.1021/acssensors.8b00365

Topics on Intelligent nanoparticles for nanomedicine

  1. Z. Huang, M. Guan, Z. Bao, F. Dong, X. Cui, Guozhen Liu*, Ligand Mediation for Tunable and Oxide Suppressed Surface Gold-Decorated Liquid Metal Nanoparticles. Small, 2024, 20: 2470053. https://doi.org/10.1002/smll.202470053
  2. Z. Huang, S. Zou, Guozhen Liu*, Surface Modification of Liquid Metal with p-Aniline Derivatives toward, ACS Applied Materials & Interfaces 2022, 14 (51), 56429-56439, https://doi.org/10.1021/acsami.2c10139
  3. M. Baharfar, M. Mayyas*, M. Rahbar, F. Allioux, J. Tang, Y. Wang, Z. Cao, F. Centurion, R. Jalili, Guozhen Liu*, K. Kalantar-Zadeh*, Exploring Interfacial Graphene Oxide Reduction by Liquid Metals: Application in Selective Biosensing, ACS Nano, 2021, 15 (12), 19661-19671, https://doi.org/10.1021/acsnano.1c06973
  4. Guozhen Liu*, C. Bursill, S. P. Cartland, A. G. Anwer, L. M. Parker, K. Zhang, S. Feng, M. He, D. W. Inglis, M. M. Kavurma, M.R. Hutchinson, E. M Goldys*, A nanoparticle-based affinity sensor that identifier and select highly cytokine-secreting cells, iScience, 2019, 20, 137-147, https://doi.org/10.1016/j.isci.2019.09.019
  5. K. Ma, G-J. Liu, L. Yan, S. Wen, B. Xu, W. Tian, E. Goldys, Guozhen Liu*, AIEgen based PLGA magnetic nanoparticles to localize cytokine VEGF for early diagnosis and photothermal therapy, Nanomedicine, 2019, 14(9). 1191-1201, https://doi.org/10.2217/nnm-2018-0467
  6. K. Ma, F., Zhang, N. Sayyadi, W. J. Chen, A. Anwer, A. Care, B. Xu, W. J. Tian, E. M. Goldys, Guozhen Liu*, Turn-on fluorescent aptasensor based on AIEgen labelling for the localisation of IFN-y in live cells, ACS Sens., 2018, 3(2), 320-326. https://pubs.acs.org/doi/10.1021/acssensors.7b00720