博士（复旦大学）

学士（武汉大学）

郭雪博士2014年获得复旦大学生物化学与分子生物学博士学位，博士后训练期间在美国斯坦福大学从事膜蛋白相关的研究工作，2020-2023年担任斯坦福医学中心研究科学家。现任香港中文大学（深圳）医学院及科比尔卡创新药物研究院助理教授、博士生导师。主要研究方向是溶酶体氨基酸转运和信号传导机制。

1. Xue Guo*, Jianxiu Zhang*, Lei Han*, Juliet Lee, Shoshana C. Williams, Allison Forsberg, Yan Xu, Rachel Narehood Austin, and Liang Feng. Structure and mechanism of the alkane-oxidizing enzyme AlkB. Nat. Commun. 14, 2180 (2023).

2. Xue Guo*, Philip Schmiege*, Tufa E. Assafa*, Rong Wang, Yan Xu, Linda Donnelly, Michael Fine, Xiaodan Ni, Jiansen Jiang, Glenn Millhauser, Liang Feng and Xiaochun Li. Structure and mechanism of human cystine exporter cystinosin. Cell. 2022 Sep 29;185(20):3739-3752

3. Xue Guo*, Ling Wang*, Jie Li, Jianxiong Xiao, Xiaotong Yin, Shuang He, Pan Shi, Liping Dong, Zhanyu Ding, Guohong Li, Changlin Tian, Yao Cong, Jiawei Wang, and Yanhui Xu.  Structural insight into autoinhibition and histone H3-induced activation of DNMT3A. Nature. 2015 Jan 29;517(7536):640-4

4. Zhang Y*, Yang H*, Guo X*, Rong N, Song Y, Xu Y, Lan W, Zhang X, Liu M, Xu Y, Cao C.  The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B. Protein Cell. 2014 Jun 22;5(11):837-50

5. Ma H*, Chen H*, Guo X*, Wang Z, Sowa ME, Zheng L, Hu S, Zeng P, Guo R, Diao J, Lan F, Harper JW, Shi YG, Xu Y, Shi Y.  M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability. Proc. Natl Acad. Sci. USA. 2012 Mar 27; 109(13): 4828-33

6. Lei K*, Zhang X*, Ding X, Guo X, Chen M, Zhu B, Xu T, Zhuang Y, Xu R, Han M.  SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice. Proc. Natl Acad. Sci. USA. 2009 Jun 9; 106(25): 10207-12