郭景慧

校长青年学者

助理教授

教育背景

博士（香港中文大学）

硕士（中山大学）

学士（中山大学）

研究领域
离子通道在生殖及内分泌系统中的生理功能研究；离子通道光、超声调控相关工具的开发及在内分泌、免疫以及神经系统中的应用
电子邮件
guojinghui@cuhk.edu.cn
个人简介

郭景慧教授于2006年毕业于中山大学生命科学学院，2008年获得于中山大学获得生理学硕士学位，2013年获得香港中文大学医学院生理学博士学位，随后在香港中文大学完成三年博士后的培训；2016-2022年，郭教授曾任暨南大学医学院生理学系副教授；2023年1月任香港中文大学（深圳）医学院助理教授。

科研兴趣包括基础研究与交叉研究两个方面。基础研究主要集中于离子通道在生殖及内分泌系统中的生理病理功能探索；交叉研究主要以离子通道的光、声调控展开，尝试建立以离子通道为生物学开关，利用光或超声相关技术达到对细胞远程精准调控的目标，从而开发神经、内分泌及免疫系统的调控工具箱，为临床治疗神经、内分泌及免疫相关的疾病提供新手段。郭教授先后主持国家自然科学基金2项，1项省级人才项目及多项省市级项目。目前，课题组发表SCI论文37篇，第一作者（含共同第一作者）、通讯作者论文包括Nature Medicine, Nature Communications, EMBO Molecular Medicine, Advanced Science, Cell reports, iScience, Endocrinology, BBA-Molecular Basis of Disease等；总引用数达1100余次，H-index为18。

学术著作

基础研究:

  1. Guo JH, Chen H, Ruan YC, Zhang XL, Zhang XH, Fok KL, Tsang LL, Yu MK, Huang WQ, Sun X, Chung YW, Jiang X, Sohma Y, Chan HC#. Glucose-induced electrical activities and insulin secretion in pancreatic islet β-cells are modulated by CFTR. Nature Communications. 2014 Jul 15;5:4420. doi: 10.1038/ncomms5420.
  2. Ruan YC*, Guo JH*, Liu X, Zhang R, Tsang LL, Dong JD, Chen H, Yu MK, Jiang X, Zhang XH, Fok KL, Chung YW, Huang H#, Zhou WL#, Chan HC#.  Activation of the epithelial Na(+) channel triggers prostaglandin E(2) release and production required for embryo implantation. Nature Medicine. 2012 Jun 24. doi: 10.1038/nm.2771. (* co-first author )
  3. Xiao Sun*, Jing Hui Guo*, Dan Zhang, Jun-jiang Chen, Wei Yin Lin, Yun Huang, Hui Chen, Wen Qing Huang, Yifeng Liu, Lai Ling Tsang, Mei Kuen Yu, Yiu Wa Chung, Xiaohua Jiang, Hefeng Huang, Hsiao Chang Chan#,Ye Chun Ruan#. Activation of the epithelial sodium channel (ENaC) leads to cytokine profile shift to pro-inflammatory in labor. EMBO Molecular Medicine. 2018 Oct;10(10). pii: e8868. doi: 10.15252/emmm.201808868 (* co-first author)
  4.  Huang WQ*, Guo JH*, Zhang XH, Yu MK, Chung YW, Ruan YC#, Chan HC#. Glucose-Sensitive CFTR Suppresses Glucagon Secretion by Potentiating KATP Channels in Pancreatic Islet α Cells. Endocrinology. 2017 Oct 1;158(10):3188-3199. (* co-first author)
  5. Xue-Lian Zhang, Xinyi Zhao, Yong Wu, Wen-qing Huang, Jun-jiang Chen, Peijie Hu, Wei Liu, Yi-Wen Chen, Jin Hao, Rong-Rong Xie, Hsiao Chang Chan, Ye Chun Ruan, Hui Chen#, Jinghui Guo#.  Angiotensin (1–7) activates MAS-1 and upregulates CFTR to promote insulin secretion in pancreatic β-cells: the association with type 2 diabetes. Endocrine Connection. 2022 Jan 11;11(1):e210357. doi: 10.1530/EC-21-0357.
  6. Zhenqing Liu, Jinghui Guo, Yan Wang, Zhihui Weng, Biao Huang, Mei-Kuen Yu, Xiaohu Zhang, Ping Yuan, Hui Zhao, Wai-Yee Chan, Xiaohua Jiang and Hsiao-Chang Chan. CFTR-β-catenin interaction regulates mouse embryonic stem cell differentiation and embryonic development. Cell Death Differ. 2017 Jan;24(1):98-110. doi: 10.1038/cdd.2016.118.
  7.  Chen H, Guo JH, Lu YC, Ding GL, Yu MK, Tsang LL, Fok KL, Liu XM, Zhang XH, Chung YW, Huang P, Huang H, Chan HC Impaired CFTR-dependent amplification of FSH-stimulated estrogen production in cystic fibrosis and PCOS. J Clin Endocrinol Metab. 2012 Mar;97(3):923-32. Epub 2011 Dec 14.

 

交叉研究:

  1. Jinghui Guo*#, Yong Wu*, Zhiyong Gong, Xixi Chen, Fei Cao, Shashwati Kala, Zhihai Qiu, Xinyi Zhao, Jun‐jiang Chen, Dongming He, Taiheng Chen, Rui Zeng, Jiejun Zhu, Kin Fung Wong, Suresh Murugappan, Ting Zhu, Quanxiang Xian, Xuandi Hou, Ye Chun Ruan, Baojun Li, Yu Chao Li#, Yao Zhang#, Lei Sun#. Photonic Nanojet‐Mediated Optogenetics. Advanced Science. 2022 Feb 20;e2104140. doi: 10.1002/advs.202104140.
  2. Zhihai Qiu*, Shashwati Kala*, Jinghui Guo*, Quanxiang Xian*, Jiejun Zhu, Ting Zhu, Xuandi Hou, Kin Fung Wong, Minyi Yang, Haoru Wang, and Lei Sun Targeted Neurostimulation in Mouse Brains with Non-invasive Ultrasound. Cell reports Volume 32, Issue 7, 18 August 2020, 108033(* co-first author)
  3. Zhihai Qiu*, Jinghui Guo*, Shashwati Kala*, Jiejun Zhu*, Quanxiang Xian, Weibao Qiu, Guofeng Li, Ting Zhu, Long Meng, Rui Zhang, Hsiao Chang Chan, Hairong Zheng, Lei Sun# The Mechanosensitive Ion Channel Piezo1 Significantly Mediates In Vitro Ultrasonic Stimulation of Neurons. iScience. 2019 Nov 22; 21: 448–457. (* co-first author) 
  4. X Chen, T Wu, Z Gong, J Guo, X Liu, Y Zhang, Y Li, P Ferraro, B Li Lipid droplets as endogenous intracellular microlenses. Light: Science & Applications 10 (1), 1-11
  5. Tianli Wu, Xixi Chen, Zhiyong Gong, Jiahao Yan, Jinghui Guo, Yao Zhang, Yuchao Li, Baojun Li Intracellular Thermal Probing Using Aggregated Fluorescent Nanodiamonds. Advanced Science. 2021 Nov 23;e2103354.
  6. Zhiyong Gong, Tianli Wu, Xixi Chen, Jinghui Guo, Yao Zhang, Yuchao Li Upconversion Nanoparticle Decorated Spider Silks as Single-Cell Thermometers Nano Lett. 2021 Feb 10;21(3):1469-1476.
  7. Xuandi Hou, Zhihai Qiu, Quanxiang Xian, Shashwati Kala, Jianing Jing, Kin Fung Wong, Jiejun Zhu, Jinghui Guo, Ting Zhu, Minyi Yang, Lei Sun Precise Ultrasound Neuromodulation in a Deep Brain Region Using Nano Gas Vesicles as Actuators Advanced Science 8 (21), 2101934