崔小林

校长青年学者

助理教授

教育背景

博士（阿德莱德大学）
硕士（阿德莱德大学）
本科（大连理工大学）

研究领域
生物制造、干细胞与无细胞治疗、组织工程与再生医学、软骨与骨组织工程、心肌组织工程
电子邮件
stevencui@cuhk.edu.cn
个人简介

作为一名生物化学工程师，崔博士在2017年从阿德莱德大学完成博士学位后，加入了奥塔哥大学担任博士后研究员，随后于2019年晋升为研究员(助理教授级别)。2021年，他还被任命为大连医科大学附属第一医院骨科的特聘副教授。2022年7月，正式加入香港中文大学（深圳）医学院担任生物医学工程的助理教授。

崔博士的专业领域涉及干细胞、生物材料、生物制造和组织工程的交叉领域，尤其关注软骨和骨再生以及心血管疾病的诊断和治疗。他在聚合物合成、组织培养、抗癌药物筛选、药物和基因传递系统以及干细胞疗法方面具有丰富经验。目前，他正在领导多项组织工程的临床前实验。

崔博士曾获得了国际生物制造学会颁发的2021年WFIRM青年研究者奖。此外，他还先后获得了阿德莱德大学的博士奖学金、奥塔哥大学博士后研究基金、新西兰国家心脏基金会研究员基金、新西兰商业、创新与就业部(MBIE)的Science Whitinga研究员基金。崔博士主持了新西兰卫生研究委员会的探索者资助和心脏基金会的重大项目。

崔博士是新西兰皇家学会（RSNZ）和皇家化学学会、美国化学学会、国际生物制造学会（ISBF）的会员，曾是澳大利亚和新西兰生物材料与组织工程学会（ASBTE）的青年科学家代表（新西兰），并作为新西兰代表参加了2022年全球青年科学家峰会。目前，他担任《Frontiers in Biomaterials Science》的副编辑，并在《Exploration》、《Military Medical Research》和《Extracellular Vesicles and Circulating Nucleic Acids》等期刊的青年委员会中任职。他还担任了《Frontiers in Bioengineering and Biotechnology》的客座编辑。崔博士还是包括《Science Advances》、《Advanced Materials》、《Advanced Functional Materials》等在内的20多个SCI期刊的特邀审稿人。

学术著作

发表期刊

  1. Z. Fu, K. Fan, X. He, Q. wang, J. Yuan, K. Lim, J. Tang, F. Xie, X. Cui*, Single-atom-based nano-enzyme in tissue repair, ACS Nano, 2024, accepted. Last Author
  2. X. Cui, J. Guo, P. Yuan, Y. Dai, P. Du, F. Yu, Z. Sun, J. Zhang, J. Tang, K. Cheng, Bio-Derived Nanoparticles for Cardiac Repair, ACS Nano, 2024, accepted.
  3. Z. Bao, S. Lu, D. Zhang, G. Wang, X. Cui*, G. Liu*, Wearable microneedle patch for colorimetric detection of multiple signature biomarkers in vivo towards diabetic diagnosis, Advanced Healthcare Materials, 2024, 2303511. Co-corresponding author.
  4. P. Du, Y. Hou, C. Su, J. Gao, Y. Yang, J. Zhang, X. Cui* and J. Tang, The future for the therapeutics of Abdominal Aortic Aneurysm: Engineered Nanoparticles Drug Delivery for Abdominal Aortic Aneurysm, Frontiers in Bioengineering and Biotechnology, 2024, online. Co-corresponding author.
  5. S. Zou, J. Li, S. Lu, D. Li, Y. Liu, W. Zhang, X. Cui, J. Gooding, K. Tian, G. Liu, CRISPR/Cas12a immunosensing on glass fiber for point-of-care quantifying multiple inflammation biomarkers in osteoarthritis, Device, 2024, online. Cover Article.
  6. H. Cao, S. Deng, X. Chen, X. Cui, T. Yuan, J. Liang, X, Zhang, Y. Fan, Q. Wang, An injectable cartilage-coating composite with long-term protection, effective lubrication and chondrocyte nourishment for osteoarthritis treatment, Acta Biomaterialia, 2024, online.
  7. M. Chen, Y. Lu, Y. Liu, Q. Liu, S. Deng, Y. Liu, X. Cui, J. Liang, Y. Fan, Q. Wang, X. Zhang, Injectable microgels with hybrid exosomes of chondrocyte-targeted FGF18 gene-editing and self-renewable lubrication for osteoarthritis therapy, Advanced Materials, 2024, online.
  8. F. Xie#, X. Cui#, X. Zhi, D. Yao, B. Johannessen, Q. Zhang, J. Tang, T. Woodfield, L. Gu and S. Qiao, A 3D- Printing Synthesis of Single Atom Catalysts, Nature Synthesis, 2023, 2, 129-139. Co-first author.
  9. Y. Dai, K. Qiao, D. Li, P. Isingizwe, H. Liu, Y. Liu, K. Lim, T. Woodfield, G. Liu, J. Hu, J. Yuan*, J. Tang*, X. Cui* Plant-derived biomaterials and their potential in cardiac tissue repair, Advanced Healthcare Materials, 2023, 2202827. Last author.
  10. D. Li, G. Zhang, J. Guo, Y. Liu, Y Lu, Z Qin, Y. Xu, C. Cao, B. Wang, Q. Guo, Y. Wang, G. Liu, X. Cui*, J. Zhang*, J. Tang*, Idebenone attenuates ferroptosis by inhibiting excessive autophagy via the ROS-AMPK-mTOR pathway to preserve cardiac function after myocardial infarction, European Journal of Pharmacology, 2023, 943, 175569. Co-corresponding author.
  11. K. Qiao, XY.Cui, J. Gao, F. Yu, H. Liu, Y. Dai, J. Liu, X. Yang, X. Xian, J. Hu, J. Tang*, X. Cui*, Roles of Extracellular Vesicles Derived from Immune Cells in Atherosclerosis, Extracellular Vesicle, 2023, 2, 100028. Last Author.
  12. H. Gao, M. Chen, X. Cui, Y. Liu, S. Deng, T. Yuan, Y. Fan, Q. Wang, X. Zhang, Cell-Free Osteoarthritis Treatment with Sustained-Release of Chondrocyte-Targeting Exosomes from Umbilical Cord-Derived Mesenchymal Stem Cells to rejuvenate ageing chondrocytes, ACS Nano, 2023, 17,13358.
  13. Z. Huang, M. Guang, Z. Bao, F. Dong, X. Cui, G. Liu, Ligand Mediation for Tunable and Oxide Suppressed Surface Gold-Decorated Liquid Metal Nanoparticles, Small, 2023, 2306652. Cover article.
  14. M. Ho, Q. Hilst, X.Cui, Y. Ramaswamy, T. Woodfield, J. Rnjak-Kovacina, S. Wise, K. Lim, From Adhesion to Detachment: Strategies to Design Tissue Adhesive Hydrogels, Advanced Nanobiomed Research, 2023, online.
  15. Y. Yang, J. Gao, Z. Qin, Y. Lu, Y. Xu, J. Guo, X. Cui, J. Zhang*, J. Tang*, The Present Clinical Treatment and Future Emerging Interdisciplinary for Heart Failure: Where we are and What we can do, Intensive Care Research, 2023, 3, 3-11.
  16. Y. Liu, S. Lu, Z. Zhang, Z. Yang, X. Cui, G. Liu*, Printable biosensors towards next generation point-of-care testing: paper substrate as an example, Lab on a Chip, 2023, 23, 3353.
  17. Z.Zou, H. Li, K. Yu, K. Ma, Q. Wang, J. Tang, G. Liu, K. Lim, G. Hooper, T. Woodfield, X. Cui*, W. Zhang*, K. Tian*, The potential role of synovial cells in the progression and treatment of osteoarthritis, Exploration, 2023, 20220132. Co-corresponding author. Cover article.
  18. C. Su, Y. Lu, Z. Wang, J. Guo, Y. Hou, X. Wang, Z. Qin, J. Gao, Z. Sun, Y. Dai, Y. Liu, G. Liu, X. Xian, X. Cui*, J. Zhang*, J. Tang*, Atherosclerosis: The Involvement of Immunity, Cytokines and Cells in Pathogenesis, and Potential Novel Therapeutics, Aging and Disease, 2023, 14,1214. Co-corresponding author.
  19. G. Zhang, X. Cui, Z. Qin, Z. Wang, Y. Lu, Y. xU, S. Xu, L. Tang, L. Zhang, G. Liu, X. Wang, J. Zhang and J. Tang, Atherosclerotic plaque vulnerability quantification system for clinical and biological interpretability , iSciene, 2023, 26, 107587.
  20. S Deng, H Cao, X Cui, Y Fan, Q Wang, X Zhang, Optimization of exosome-based cell-free strategies to enhance endogenous cell functions in tissue regeneration, Acta Biomaterialia, 2023, online.
  21. X. Cui#,*, C. Alcala-Orozco#, K. Baer, J. Lin, C. Murphy, M. Durham, G. Hooper, K. Lim and T. Woodfield*, 3D bioassembly of cell-instructive microgel spheroid bioinks for hybrid biofabrication of allogeneic tissue-engineered osteochondral constructs, Biofabrication, 2022, 14, 034101. Co-corresponding author.
  22. K. Qiao, L. Xu, J. Tang, Q. Wang, K. Lim, G. Hooper, T. Woodfield, G. Liu, K. Tian*, W. Zhang* and X. Cui*, Advances in Nanomedicine for Cartilage and Bone repair, Journal of Nanobiotechnology, 2022, 20(1), 1-42. Last author.
  23. Z. Wang, Z. Qin, R. Yuan, S. Xu, Y. Lv, F. Yu, L. Tang, L. Zhang, J. Bai, X. Cui*, J. Zhang*, and J. Tang*, Systemic immune‐inflammation index as a prognostic marker for advanced chronic heart failure with renal dysfunction, ESC Heart Failure, 2022, 10 (1), 478-491 Co-corresponding author
  24. D. Li, T. Kang, J. Guo, Q. Wang, Z. Qin, Y. Lu, Y. Xu, N. Scott, C. Charles, G. Liu, J. Zhang*, X. Cui* and J. Tang*, Growth factors: avenue for the treatment of myocardial infarction and their delivery strategies, Regenerative Medicine, 2022, 17, 561-579. Co-corresponding author
  25. J. Li, X. Cui, G. Lindberg, C. Alcala-Orzco, G. Hooper, K. Lim and T. Woodfield, Integration of Ti-6Al-4V implants with vascular bioinks for vascularized bone regeneration, Biofabrication, 2022, 14, 034103.
  26. Y. Hou, X. Cui, Z. Qin, C. Su, G. Zhang, J, Tang, J. Li and J. Zhang, Three0dimensional bioprinting for artificial blood vessel: process, bioinks and challenges, International Journal of Bioprinting, 2023, online.
  27. J. Tang, S. Xu, Z. Qin, R. Yuan, X. Cui, Z. Wang, F. Yu, Y. Lv, J. Zhang, L. Zhang, J. Bai, G. Liu, The haemoglobin glycation index predicts the risk of adverse cardiovascular adverse events in coronary heart disease patients with type 2 diabetes mellitus, Frontiers in Cardiovascular Medicine, 2022, 9, 992252.
  28. G. Zhang, X. Cui, L. Zhang, W. Wang, G. Liu, X. Zhu, J. Shangguan, W. Zhang, Y. Zhang, J Tang and J. Zhang, Uncovering pathogenic and genetic link of SARS-CoV-2 infections on heart failure comorbidity, ESC Heart Failure, 2022, 9, 2937-2954.
  29. S. Zou, H. Wei, X. Cui, W. C. Mak, and G. Liu, Intercalating methyl blue to molecular beacon for sensitive detection of salivary TNF-α towards early diagnosis of oral cancer, Sensors & Diagnostics, 2022, 1, 731-738.
  30. Y. Dai, X. Cui, G. Zheng, A. Mohsin, H. Xu, Y. Zhang and M. Guo, Development of a novel feeding regime for large scale production of human umbilical cord mesenchymal stem cells, Cytotechnology, 2022, 74, 351-369 .
  31. J. Tang#,*, X. Cui#,*, Z. Zhang#, Y. Xu, Y. Lu, Q. Wang, H. Zhang, K. Lim, T. Woodfield and J. Zhang*, Injection-free delivery of MSC-derived extracellular vesicles for myocardial infarction therapeutics, Advanced Healthcare Materials, 2022, 11(5), 2100312.Co-first and corresponding author
  32. Y. Lu#, X. Cui#, L. Zhang, Y. Xu, Z. Qin, G. Liu, Q. Wang, K. Tian, J. Zhang and J. Tang, The functional role of lipoproteins in Atherosclerosis: a novel direction of diagnosis and targeted therapy, Aging and disease, 2020, 13(2), 491. Co-first author
  33. C. Alcala-Orozco, I. Mutrejia, X. Cui, G. Hooper, K. Lim and T. Woodfield, Development of nanocomposite Mg-PCL biomaterial inks for hybrid biofabrication of skeletal regenerative 3D construct, Bone, 2022, 154, 116198.
  34. H. Cao, X. Wang, X. Cheng, Y. Liu, X. Cui, J. Liang, Q. Wang, Y. Fan and X. Zhang, Childhood cartilage ECM enhances the chondrogenesis of endogenous cells and subchondral bone repai of the unidirectional collagen-dECM scaffold in combination with microfracture, ACS Applied Materials and Interfaces, 2021, 13(48), 57043.
  35. G. Lindberg, X. Cui, M. Durham, L. Doornkamp-Veenendaal, B. Schon, G. Hooper, K. Lim, and T. Woodfield, Probing Multicellular Tissue Fusion of Co-Cultured Spheroids - a 3D Bioassembly Model, Advanced Sciences, 2021, 8(22), 2103320.
  36. H. Kim#, B. Kang#, X. Cui#, S. Lee, D. Cho, T. Woodfield, K. Lim and J. Jang, Light-activated decellularized extracellular matrix-based bioink for volumetric tissue analogs in centimeter-scale, Advanced Functional Material, 2021, 31(32), 2011252. Co-first author. Cover article
  37. E. Aldrich#, X. Cui#, C. Murphy#, K. Lim, G. Hooper, W. McIlwraith, and T. Woodfield, Allogeneic mesenchymal stromal cells for cartilage regeneration: A review on in vitro evaluation, clinical experience and translational opportunities, Stem Cells Translational Medicine, 2021, 10(11), 1500. Co-first author.
  38. K. Qiao, Q. Chen, Y. Cao, J. Li, G. Xu, X. Cui*, K. Tian* and W. Zhang*, Diagnostic and therapeutic role of extracellular vesicle in articular cartilage lesions and degenerative joint disease, Frontiers in Bioengineering and Biotechnology, 2021, 9, 698614. Co-corresponding author.
  39. M. Li, F. Ren, J. Tian, K. Yang, H. Song, X. Cui, D. Yin, The evaluation of electrocardiogram and echocardiographic characteristics of the Pre- and Post-operation of his bundle pacing: a comprehensive review and meta-analysis, Anatolian Journal of Cardiology, 2021, 25(12), 845.
  40. Y. Liu, Y. Wang, H. Zhang, Z. Tang, X. Cui, W. Li, J. Liang, Q. Wang, Y. Fan, X. Zhang, solubilized cartilage ECM facilitates the recruitment and chondrogenesis of endogenous BMSCs in collagen scaffold for enhancing microfracture treatment, ACS Applied Materials& Interface, 2021, 13(21), 24553.
  41. Z. Zhang, J. Tang, X. Cui, B. Qin, J. Zhang, L. Zhang, H. Zhang, G. Liu, W. Wang and J. Zhang, New insights and novel therapeutic potentials for macrophages in myocardial infarction, Inflammation, 2021, 44(5), 1696.
  42. C. Alcala-Orzco, X. Cui, G. Hooper, K. Lim and T. Woodfield, Convergent functionality: Strategies for 3D hybrid-construct biofabrication and the role of composite biomaterials for skeletal regeneration, Acta Biomaterialia, 2021, 132,188.
  43. J. Zhang#, X. Cui#, J. Guo, C. Cao Z. Zhang, B. Wang, L. Zhang, D. Shen, K. Lim, T. Woodfield, J. Tang and J. Zhang, Small but significant: Insights and New Perspectives of Exosomes in Cardiovascular Disease, Journal of Cellular and Molecular Medicine, 2020, 24, 8291.  Co-first author
  44. X. Cui, J. Li, Y. Hartanto, M. Durham, J. Tang, H. Zhang, G, Hooper, K. Lim and T. Woodfield, Advances in Extrusion 3D Bioprinting: A Focus on Multicomponent Hydrogel-based Bioinks, Advanced Healthcare Materials, 2020, 9, 1901648.
  45. P. Atienza-Roca, D. Kieser, X. Cui, R. Yogambha, G. Hooper, A. Clarkson, J. Rnjak-Kovacina, P. Martens, L. Wise, T. Woodfield and K. Lim, Visible Light Mediated PVA-Tyramine Hydrogels for Covalent Incorporation and Controlled Release of Functional Growth Factors, Biomaterials Science, 2020, 8, 5005. Editor selected hot article. Cover article.
  46. K. Lim, J. Galarraga, X. Cui, G. Lindberg, J. Burdick, T. Woodfield, Fundamentals and Applications of Photocrosslinking in Bioprinting, Chemical Reviews, 2020, 120, 10662.
  47. X. Cui, B. Soliman, C. Alcala-Orzco, J. Li, M. Vis, M. Santo, S. Wise, R. Levato, J. Malda, T. Woodfield, J. Rnjak-Kovacina and K. Lim, Rapid Photo-Crosslinking of Silk Hydrogels with High Cell-Density and Enhanced Shape Fidelity, Advanced Healthcare Materials, 2020, 9,1901667.
  48. M. Baptista, H. Joukhdar, C. Alcala-Orozco, K. Lai, S. Jiang, X. Cui, S. He, F. Tang, C. Heu, T. Woodfield, K. Lim and J. Rnjak-Kovacina, Silk fibroin photo-lyogels containing microchannels as a biomaterial platform for in situ tissue engineering, Biomaterials Science, 2020, 8, 7093.
  49. J. Li, X. Cui, G. Hooper, K. Lim and T. Woodfield, Rational design, bio-functionalization and biological performance of hybrid additive manufactured titanium implants for orthopaedic applications: a review, Journal of the Mechanical Behavior of Biomedical Materials, 2020,103671.
  50. C. Alcala-Orzco, I. Mutreja, X. Cui, K. Lim and T. Woodfield, Design and Characterization of multi-functional strontium-gelatin nanocomposite bioinks with improved print fidelity and osteogenic capacity, Bioprinting, 2020, 18, e00073.
  51. J. Zhang, J. Tang, X. Cui, B. Wang, M. Bu, Y. Bai, K. Wang, J. Guo, D. Shen, J. Zhang, Indirect comparison of novel oral anticoagulants among Asians with non-valvular atrial fibrillation in the real world setting: a network meta-analysis, BMC Cardiovascular Disorders, 2019, 19, 182.
  52. Y. Hartanto, M. Zargar, X. Cui, B. Jin and S. Dai, Non-ionic copolymer microgels as high-performance draw materials for forward osmosis desalination, Journal of Membrane Science, 2019, 572, 480-488.
  53. X. Cui, J. Tang, Y. Hartanto, J. Bi, S. Dai, K. Cheng, SZ. Qiao and H. Zhang, NIPAM-based microgel microenvironment regulates cardiac stromal cells for myocardial infarction treatment, ACS Applied material & Interface, 2018, 10(44), 37783-37796.
  54. X. Cui, Y. Hartanto, J. Bi, S. Dai and H. Zhang, Tuning microenvironment for multicellular spheroid formation in thermo-responsive anionic microgel scaffolds, Journal of Biomedical Materials Research Part A, 2018, 106(11), 2899-2909.
  55. J. Guo, J. Tang, X. Cui, L. Zhang, H. Zhang, C. Cao, B. Wang and J, Zhang, Elevated Red Cell Distribution Width is Associated with Poor Clinical Outcomes in No-Ischemic Dilated Cardiomyopathy, International Journal of Clinical and Experimental Medicine, 2018, 11(8), 8102-8109.
  56. A. Mohammad, X. Cui, H. Zhang and F. Young, Three dimensional in vitro culture of murine secondary follicles in a defined synthetic matrix, Journal of Biomaterials and Nanotechnology, 2018, 9, 244-262.
  57. J. Tang, J. Cores, K. Huang, X. Cui, L. Luo, J. Zhang, T. Li, L. Qian and K. Cheng, Concise Review: Is Cardiac Cell Therapy Dead? Embarrassing Trial Outcomes and New Directions for the Future, Stem Cells Translational Medicine, 2018, 7, 354-359.
  58. J. Tang#, X. Cui#, T. Caranasos, M. Hensley, A. Vandergriff, Y. Hartanto, J. Zhang, H. Zhang and K. Cheng, Heart Repair Using Nanogel-Encapsulated Human Cardiac Stem Cells in Mice and Pigs with Myocardial Infarction, ACS Nano, 2017, 11, 9738-9749. Editor choice. Co-first author.
  59. X. Cui, Y. Hartanto, H. Zhang, Advances in multicellular spheroids formation, Journal of the Royal Society Interface, 2017, 14, 20160877. Top 10 most cited article in 2018 & 2019.
  60. L. Yan, X. Cui, T. Harada, S. Lincoln, S. Dai and T, Kee, Generation of Fluorescent and Stable Conjugated Polymer Nanoparticles with Hydrophobically Modified Poly(acrylate)s, Macromolecules, 2016, 49, 8530-8539.
  61. X. Cui, Y. Liu, Y. Hartanto, J. Bi, S. Dai and H. Zhang, Multicellular spheroids formation and recovery in microfluidics-generated thermoresponsive microgel droplets. Colloid and Interface Science Communications, 2016, 14, 4-7.
  62. X. Cui, S. Dini, S. Dai, J. Bi, B. J. Binder, J. E. F. Green and H. Zhang, A mechanistic study on tumour spheroids formation in thermosensitive hydrogels: experiments and mathematical modelling, RSC Advances, 2016, 6, 73282-73291.
  63. Y. Hartanto, M. Zargar, X. Cui, Y. Shen, B. Jin and S. Dai, Thermoresponsive cationic copolymer microgels as high-performance draw agents in forward osmosis desalination, Journal of Membrane Science, 2016, 518, 273-281.
  64. Y. Liu, Z. Wang, L. Lia, X. Cui, J. Chua, S. Zhang and Y. Zhuang, On-line monitoring the aggregate size distribution of Carthamustinctorius L. cells with multi-frequency capacitance measurements, RSC Advances, 2016, 6, 89764 - 89769.
  65. H. Zhang, X. Cui, S. Dai, J. Bi, Single-cell analysis for bioprocessing, Engineering in Life Sciences, 2015, 15, 582–592.