王勇斐

校长青年学者

助理教授

教育背景

博士 (香港大学)
学士/硕士 (福建农林大学)
 

研究领域
生物信息学与遗传学、自身免疫性疾病（系统性红斑狼疮）、多组学数据分析、药物靶标筛选与药物重定位（“老药新用”）、遗传检测
电子邮件
yfwang@cuhk.edu.cn
个人简介

王勇斐教授自2005年起开始修读生物信息学专业，在福建农林大学取得生物信息学专业的学士和硕士学位，继而于2016年在香港大学获得该专业的博士学位。王勇斐教授过往的研究运用多组学数理分析的方法，探索自身免疫性疾病的遗传机制。在博士后研究期间，王勇斐教授参与了多项国内外合作项目，挖掘出了超过130个与系统性红斑狼疮（SLE）相关的基因座。结合功能基因组数据，进一步揭示了系统性红斑狼疮群体特异、细胞特异的遗传调控机制。截止至2022年，王勇斐教授发表了32篇学术论文，其中包括Nature Genetics, Nature Communications, Annals of the Rheumatic Diseases 和Arthritis & Rheumatology等学术期刊。王勇斐教授于2022年作为助理教授加入香港中文大学（深圳）医学院，王教授课题组未来的研究方向聚焦于如何将生物大数据转化为潜在的临床运用，辅助新药开发和疾病的早期诊断。

 

 

 

学术著作

Year 2022

  1. W. Ma, Y. L. Lau, W. Yang and Y. F. Wang (2022). "Random Forests Algorithm Boosts Genetic Risk Prediction of Systemic Lupus Erythematosus" Front Genet 15 August 2022 doi.org/10.3389/fgene.2022.902793.
  2. P. Tian, T. H. Chan, Y. F. Wang, W. Yang, G. Yin and Y. D. Zhang  (2022). “Multiethnic polygenic risk prediction in diverse populations through transfer learning” Front Genet 19 August 2022 doi.org/10.3389/fgene.2022.906965.
  3. Y. F. Wang, W. Wei, P. Tangtanatakul, L. Zheng, Y. Lei, Z. Lin, C. Qian, X. Qin, F. Hou, X. Zhang, L. Shao, N. Satproedprai, S. Mahasirimongkol, P. Pisitkun, Q. Song, Y. L. Lau, Y. Zhang, N. Hirankarn and W. Yang (2022). "Identification of Shared and Asian-Specific Loci for Systemic Lupus Erythematosus and Evidence for Roles of Type III Interferon Signaling and Lysosomal Function in the Disease: A Multi-Ancestral Genome-Wide Association Study" Arthritis & Rheumatology. 74(5):840-848.
  4. Q. Zhang, Y. F. Wang, X. Hu, Y. Tan, C. Gao, J. Chen, F. Han, J. Chen and Y. Yang (2022). "Association of serum cardiac troponin I and severity of coronary stenosis in patients with varied renal functions: a retrospective cohort study" BMJ Open 12(3):e054722. (Co-first authorship)
  5. T. Zhou, X. Zhu, Z. Ye, Y. F. Wang, C. Yao, N. Xu, M. Zhou, J. Ma, Y. Qin, Y. Shen, Y. Tang, Z. Yin, H. Xu, Y. Zhang, X. Zang, H. Ding, W. Yang, Y Guo, J. Harley, B. Namjou, K. Kaufman, L. Kottyan, M. Weirauch, G. Hou and N. Shen (2022). "Lupus enhancer risk variant causes dysregulation of IRF8 through cooperative lncRNA and DNA methylation machinery" Nat Commun. 13(1):1855.
  6. X. Yin, K. Kim, H. Suetsugu, S.Y. Bang, L. Wen, M. Koido, E. Ha, L. Liu, Y. Sakamoto, S. Jo, R.X. Leng, N. Otomo, Y.C. Kwon, Y. Sheng, N. Sugano, M.Y. Hwang, W. Li, M. Mukai, K. Yoon, M. Cai, K. Ishigaki, W.T. Chung, H. Huang, D. Takahashi, S.S. Lee, M. Wang, K. Karino, S.C. Shim, X. Zheng, T. Miyamura, Y.M. Kang, D. Ye, J. Nakamura, C.H. Suh, Y. Tang, G. Motomura, Y.B. Park, H. Ding, T. Kuroda, J. Choe, C. Li, H. Niiro, Y. Park, C. Shen, T. Miyamoto, G. Ahn, W. Fei, T. Takeuchi, J. Shin, K. Li, Y. Kawaguchi, Y. Lee, Y. F. Wang, K. Amano, D.J. Park, W. Yang, Y. Tada, Y.L. Lau, K. Yamaji, Z. Zhu, M. Shimizu, T. Atsumi, A. Suzuki, T. Sumida, Y. Okada, K. Matsuda, K. Matsuo, Y. Kochi, K. Yamamoto, K. Ohmura, T. Kim, S. Yang, T. Yamamoto, B. Kim, N. Shen, S. Ikegawa, H. Lee, X. Zhang, C. Terao, Y. Cui, S.C. Bae (2022). “Biological insights into systemic lupus erythematosus through an immune cell-specific transcriptome-wide association study” Ann Rheum Dis. 81(9):1273-1280.  doi: 10.1136/annrheumdis-2022-222345.

Year 2021

  1. Y. F. Wang, Y. Zhang, Z. Lin, H. Zhang, T. Y. Wang, Y. Cao, D. L. Morris, Y. Sheng, X. Yin, S. L. Zhong, X. Gu, Y. Lei, J. He, Q. Wu, J. J. Shen, J. Yang, T. H. Lam, J. H. Lin, Z. M. Mai, M. Guo, Y. Tang, Y. Chen, Q. Song, B. Ban, C. C. Mok, Y. Cui, L. Lu, N. Shen, P. C. Sham, C. S. Lau, D. K. Smith, T. J. Vyse, X. Zhang, Y. L. Lau and W. Yang (2021). "Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups." Nat Commun. 12(1): 772.
  2. Q. Song, Y. Lei, L. Shao, W. Li, Q. Kong, Z. Lin, X. Qin, W. Wei, F. Hou, J. Li, X. Guo, Y. Mao, Y. Cao, Z. Liu, L. Zheng, R. Liang, Y. Jiang, Y. Liu, L. Zhang, J. Yang, Y. L. Lau, Y. Zhang, B. Ban, Y. F. Wang and W. Yang (2021). "Genome-wide association study on Northern Chinese identifies KLF2, DOT1L and STAB2 associated with systemic lupus erythematosus." Rheumatology (Oxford). (Co-first authorship)
  3. Y. Zhang, Y. F. Wang, H. Rasheed and J. Ott (2021). "Multi-Omics Study in Revealing Underlying Pathogenesis of Complex Diseases: A Translational Perspective." Front Genet 12: 789294.
  4. X. Yin, K. Kim, H. Suetsugu, S. Y. Bang, L. Wen, M. Koido, E. Ha, L. Liu, Y. Sakamoto, S. Jo, R. X. Leng, N. Otomo, V. Laurynenka, Y. C. Kwon, Y. Sheng, N. Sugano, M. Y. Hwang, W. Li, M. Mukai, K. Yoon, M. Cai, K. Ishigaki, W. T. Chung, H. Huang, D. Takahashi, S. S. Lee, M. Wang, K. Karino, S. C. Shim, X. Zheng, T. Miyamura, Y. M. Kang, D. Ye, J. Nakamura, C. H. Suh, Y. Tang, G. Motomura, Y. B. Park, H. Ding, T. Kuroda, J. Y. Choe, C. Li, H. Niiro, Y. Park, C. Shen, T. Miyamoto, G. Y. Ahn, W. Fei, T. Takeuchi, J. M. Shin, K. Li, Y. Kawaguchi, Y. K. Lee, Y. F. Wang, K. Amano, D. J. Park, W. Yang, Y. Tada, K. Yamaji, M. Shimizu, T. Atsumi, A. Suzuki, T. Sumida, Y. Okada, K. Matsuda, K. Matsuo, Y. Kochi, H. Japanese Research Committee on Idiopathic Osteonecrosis of the Femoral, L. C. Kottyan, M. T. Weirauch, S. Parameswaran, S. Eswar, H. Salim, X. Chen, K. Yamamoto, J. B. Harley, K. Ohmura, T. H. Kim, S. Yang, T. Yamamoto, B. J. Kim, N. Shen, S. Ikegawa, H. S. Lee, X. Zhang, C. Terao, Y. Cui and S. C. Bae (2021). "Meta-analysis of 208370 East Asians identifies 113 susceptibility loci for systemic lupus erythematosus." Ann Rheum Dis. 80(5):632-640. doi: 10.1136/annrheumdis-2020-219209.
  5. M. Zhou, R. Guo, Y. F. Wang, W. Yang, R. Li and L. Lu (2021). "Application of Weighted Gene Coexpression Network Analysis to Identify Key Modules and Hub Genes in Systemic Juvenile Idiopathic Arthritis." Biomed Res Int 2021: 9957569.
  6. Y. Zhang, X. Zhou, Y. Wang, X. Liu, Y. F. Wang, Y. Lau, W. Yang and H. Zhang (2021). "Shared genetic study gives insights into the shared and distinct pathogenic immunity components of IgA nephropathy and SLE." Molecular Genetics and Genomics. 296(4):1017-1026. doi: 10.1007/s00438-021-01798-7.

Year 2020

  1. T. Wang, Y. F. Wang, Y. Zhang, J. J. Shen, M. Guo, J. Yang, Y. L. Lau and W. Yang (2020). "Identification of Regulatory Modules That Stratify Lupus Disease Mechanism through Integrating Multi-Omics Data." Mol Ther Nucleic Acids 19: 318-329.
  2. L. Chen, Y. F. Wang, L. Liu, A. Bielowka, R. Ahmed, H. Zhang, P. Tombleson, A. L. Roberts, C. A. Odhams, D. S. Cunninghame Graham, X. Zhang, W. Yang, T. J. Vyse and D. L. Morris (2020). "Genome-wide assessment of genetic risk for systemic lupus erythematosus and disease severity." Human Molecular Genetics. 29(10):1745-1756.  doi: 10.1093/hmg/ddaa030.
  3. P. Tangtanatakul, C. Thumarat, N. Satproedprai, P. Kunhapan, T. Chaiyasung, S. Klinchanhom, Y. F. Wang, W. Wei, J. Wongshinsri, D. Chiewchengchol, P. Rodsaward, P. Ngamjanyaporn, T. Suangtamai, S. Mahasirimongkol, P. Pisitkun and N. Hirankarn (2020). "Meta-analysis of genome-wide association study identifies FBN2 as a novel locus associated with systemic lupus erythematosus in Thai population." Arthritis Res Ther 22(1): 185.
  4. F. Zhang, Y. F. Wang, Y. Zhang, Z. Lin, Y. Cao, H. Zhang, Z. Y. Liu, D. L. Morris, Y. Sheng, Y. Cui, X. Zhang, T. J. Vyse, Y. L. Lau, W. Yang and Y. Chen (2020). "Independent Replication on Genome-Wide Association Study Signals Identifies IRF3 as a Novel Locus for Systemic Lupus Erythematosus." Front Genet 11: 600.

Year 2019

  1. Y. F. Wang, Y. L. Lau and W. Yang (2019). "Genetic studies on systemic lupus erythematosus in East Asia point to population differences in disease susceptibility." Am J Med Genet C Semin Med Genet.
  2. J. Shen, Y. F. Wang and W. Yang (2019). "Sex-Interacting mRNA- and miRNA-eQTLs and Their Implications in Gene Expression Regulation and Disease." Front Genet 10: 313.

Year 2018

  1. Y. F. Wang, Y. Zhang, Z. Zhu, T. Y. Wang, D. L. Morris, J. J. Shen, H. Zhang, H. F. Pan, J. Yang, S. Yang, D. Q. Ye, T. J. Vyse, Y. Cui, X. Zhang, Y. Sheng, Y. L. Lau and W. Yang (2018). "Identification of ST3AGL4, MFHAS1, CSNK2A2 and CD226 as loci associated with systemic lupus erythematosus (SLE) and evaluation of SLE genetics in drug repositioning." Ann Rheum Dis.
  2. J. Shen, C. Yang, Y. F. Wang, T. Y. Wang, M. Guo, Y. L. Lau, X. Zhang, W. Yang and Y. Sheng (2018). "HLA-IMPUTER: an easy to use web application for HLA imputation and association analysis using population-specific reference panels." Bioinformatics. Apr 1;35(7):1244-1246.
  3. H. Zhang, Y. Zhang, Y. F. Wang, D. Morris, N. Hirankarn, Y. Sheng, J. Shen, H. F. Pan, J. Yang, S. Yang, Y. Cui, D. Q. Ye, T. J. Vyse, X. Zhang, Y. L. Lau and W. Yang (2018). "Meta-analysis of GWAS on both Chinese and European populations identifies GPR173 as a novel X chromosome susceptibility gene for SLE." Arthritis Res Ther 20(1): 92.

Before 2018

  1. D. Morris, Y. Sheng, Y. Zhang, Y. F. Wang, Z. Zhu, P. Tombleson, L. Chen, D. S. Cunninghame Graham, J. Bentham, A. L. Roberts, R. Chen, X. Zuo, T. Wang, L. Wen, C. Yang, L. Liu, L. Yang, F. Li, Y. Huang, X. Yin, S. Yang, L. Ronnblom, B. G. Furnrohr, R. E. Voll, G. Schett, N. Costedoat-Chalumeau, P. M. Gaffney, Y. L. Lau, X. Zhang, W. Yang, Y. Cui and T. J. Vyse (2016). "Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus." Nat Genet.
  2. Y. Zhang, J. Yang, J. Zhang, L. Sun, N. Hirankarn, H. F. Pan, C. S. Lau, T. M. Chan, T. L. Lee, A. M. Leung, C. C. Mok, L. Zhang, Y. F. Wang, J. J. Shen, S. N. Wong, K. W. Lee, M. H. Ho, P. P. Lee, B. H. Chung, C. Y. Chong, R. W. Wong, M. Y. Mok, W. H. Wong, K. L. Tong, N. K. Tse, X. P. Li, Y. Avihingsanon, P. Rianthavorn, T. Deekajorndej, K. Suphapeetiporn, V. Shotelersuk, S. K. Ying, S. K. Fung, W. M. Lai, C. M. Wong, I. O. Ng, M. M. Garcia-Barcelo, S. S. Cherny, Y. Cui, P. C. Sham, S. Yang, D. Q. Ye, X. J. Zhang, Y. L. Lau and W. Yang (2015). "Genome-wide search followed by replication reveals genetic interaction of CD80 and ALOX5AP associated with systemic lupus erythematosus in Asian populations." Ann Rheum Dis.
  3. Y. Zhang, Y. F. Wang, J. Yang, J. Zhang, L. Sun, N. Hirankarn, H. F. Pan, C. S. Lau, T. M. Chan, T. L. Lee, A. M. Leung, C. C. Mok, L. Zhang, J. J. Shen, S. N. Wong, K. W. Lee, M. H. Ho, P. P. Lee, B. H. Chung, C. Y. Chong, R. W. Wong, M. Y. Mok, W. H. Wong, K. L. Tong, N. K. Tse, X. P. Li, Y. Avihingsanon, P. Rianthavorn, T. Deekajorndej, K. Suphapeetiporn, V. Shotelersuk, S. K. Ying, S. K. Fung, W. M. Lai, C. M. Wong, I. O. Ng, M. M. Garcia-Barcelo, S. S. Cherny, P. K. Tam, P. C. Sham, S. Yang, D. Q. Ye, Y. Cui, X. J. Zhang, W. Yang and Y. L. Lau (2015). "Meta-analysis of two Chinese populations identifies an autoimmune disease risk allele in 22q11.21 as associated with systemic lupus erythematosus." Arthritis Res Ther 17: 67. (Co-first authorship)
  4. Y. F. Wang, S. Lin, Q. Song, K. Li, H. Tao, J. Huang, X. Chen, S. Que and H. He (2014). "Genome-wide identification of heat shock proteins (Hsps) and Hsp interactors in rice: Hsp70s as a case study." BMC Genomics 15: 344.
  5. Y. Yang, X. B. Lang, P. Zhang, R. Lv, Y. F. Wang and J. H. Chen (2014). "Remote ischemic preconditioning for prevention of acute kidney injury: a meta-analysis of randomized controlled trials." Am J Kidney Dis 64(4): 574-583.
  6. Y. Zhang, J. Zhang, J. Yang, Y. F. Wang, L. Zhang, X. Zuo, L. Sun, H. F. Pan, N. Hirankarn, T. Wang, R. Chen, D. Ying, S. Zeng, J. J. Shen, T. L. Lee, C. S. Lau, T. M. Chan, A. M. Leung, C. C. Mok, S. N. Wong, K. W. Lee, M. H. Ho, P. P. Lee, B. H. Chung, C. Y. Chong, R. W. Wong, M. Y. Mok, W. H. Wong, K. L. Tong, N. K. Tse, X. P. Li, Y. Avihingsanon, P. Rianthavorn, T. Deekajorndej, K. Suphapeetiporn, V. Shotelersuk, S. K. Ying, S. K. Fung, W. M. Lai, C. M. Wong, I. O. Ng, M. M. Garcia-Barcelo, S. S. Cherny, P. K. Tam, P. C. Sham, S. Yang, D. Q. Ye, Y. Cui, X. J. Zhang, Y. L. Lau and W. Yang (2014). "Meta-analysis of GWAS on two Chinese populations followed by replication identifies novel genetic variants on the X chromosome associated with systemic lupus erythematosus." Human Molecular Genetics. Jan 1;24(1):274-84.
  7. W. Yang, P. P. Lee, M. K. Thong, T. M. Ramanujam, A. Shanmugam, M. T. Koh, K. W. Chan, D. Ying, Y. F. Wang, J. J. Shen, J. Yang and Y. L. Lau (2014). "Compound heterozygous mutations in TTC7A cause familial multiple intestinal atresias and severe combined immunodeficiency." Clin Genet.
  8. X. Chen, S. Lin, Q. Liu, J. Huang, W. Zhang, J. Lin, Y. F. Wang, Y. Ke and H. He (2014). "Expression and interaction of small heat shock proteins (sHsps) in rice in response to heat stress." Biochim Biophys Acta 1844(4): 818-828.
  9. S. Que, K. Li, M. Chen, Y. F. Wang, Q. Yang, W. Zhang, B. Zhang, B. Xiong and H. He (2012). "PhosphoRice: a meta-predictor of rice-specific phosphorylation sites." Plant Methods 8: 5.
  10. X. Chen, W. Zhang, B. Zhang, J. Zhou, Y. F. Wang, Q. Yang, Y. Ke and H. He (2011). "Phosphoproteins regulated by heat stress in rice leaves." Proteome Sci 9: 37.
  11. S. Que, Y. F. Wang, P. Chen, Y. R. Tang, Z. Zhang and H. He (2010). "Evaluation of protein phosphorylation site predictors." Protein Pept Lett 17(1): 64-69. (Co-first authorship)