叶德全
校长讲座教授, 教授
博士(华盛顿大学)
叶德全教授1982年本科毕业于上海第二医学院,并于1988年获美国圣路易斯华盛顿大学博士学位。自1989年起先后在Scripps研究所及伊利诺伊大学医学院担任助理教授、副教授、教授,其主要研究方向包括G蛋白偶联受体的信号转导及在固有免疫细胞中的作用,炎症机制和病理模型及抗炎药物靶标的发现。先后与强生、诺华、GSK等公司开展研发合作,作为第一发明人获批美国专利2项、中国专利2项,共同发明人专利2项。发表SCI学术论文230篇,被引2万多次。于2010年起担任上海交通大学讲席教授、药学院院长;2015年1月至2019年1月任澳门大学讲座教授;2019年2月加入香港中文大学(深圳),创建生命与健康科学学院; 2020年创建福田生物医药创新研发中心。获评2021年深圳市优秀教师,2022年大学杰出科研奖;多次入选科睿唯安高被引学者、斯坦福大学全球前2%顶尖科学家、爱思唯尔2022年中国高被引科学家等。学术兼职包括FASEB Journal副主编,Pharmacological Reviews 副主编,Molecular Pharmacology及British Journal of Pharmacology 编委等。欢迎有兴趣的博士后、博士生、硕士生、本科交换生联系课题组。
部分学术著作:
1. Wu MY, Ge YJ, Wang EJ, Liao QW, Ren ZY, Yu Y, Zhu G, Liu CP, Zhang MN, Su H, Shen HM, Chen Y, Wang L, Wang YT, Li M, Bian Z, Chai J, Ye RD, Lu JH. Enhancement of efferocytosis through biased FPR2 signaling attenuates intestinal inflammation. EMBO Molecular Medicine 2023 Dec 7;15(12):e17815. doi: 10.15252/emmm.202317815. Epub 2023 Nov 22. PMID: 37994307.
2. Liu Y, Liang S, Shi D, Zhang Y, Bai C, Ye RD. A predicted structure of NADPH Oxidase 1 identifies key components of ROS generation and strategies for inhibition. PLoS One. 2023 May 3;18(5):e0285206. doi: 10.1371/journal.pone.0285206. PMID: 37134122.
3. Wang J, Chen G, Liao Q, Lyu W, Liu A, Zhu L, Du Y, Ye RD. Cryo-EM structure of the human chemerin receptor 1-Gi protein complex bound to the C-terminal nonapeptide of chemerin. Proceedings of National Academy of Science U.S.A. 2023 Mar 14;120(11):e2214324120. doi: 10.1073/pnas.2214324120. Epub 2023 Mar 7. PMID: 36881626.
4. Chen G, Wang X, Liao Q, Ge Y, Jiao H, Chen Q, Liu Y, Lyu W, Zhu L, van Zundert GCP, Robertson MJ, Skiniotis G, Du Y, Hu H, Ye RD. Structural basis for recognition of N-formyl peptides as pathogen-associated molecular patterns. Nature Communications. 2022 Sep 5;13(1):5232. doi: 10.1038/s41467-022-32822-y. PMID: 36064945.
5. Wang J, Ye RD. Agonist concentration-dependent changes in FPR1 conformation lead to biased signaling for selective activation of phagocyte functions. Proceedings of National Academy of Science U.S.A. 2022 Aug 2;119(31):e2201249119. doi: 10.1073/pnas.2201249119. Epub 2022 Jul 25. PMID: 35878025.
6. Liao Q, Ye RD. Structural and conformational studies of biased agonism through formyl peptide receptors. American Journal of Physiology - Cellular Physiology. 2022 Apr 6. doi: 10.1152/ajpcell.00108.2022. Epub ahead of print. PMID: 35385323.
7. Belambri SA, Marzaioli V, Hurtado-Nedelec M, Pintard C, Liang S, Liu Y, Boussetta T, Gougerot-Pocidalo MA, Ye RD, Dang PM, El-Benna J. Impaired p47phox phosphorylation in neutrophils from patients with p67phox-deficient chronic granulomatous disease. Blood. 2022 Apr 21;139(16):2512-2522. PMID: 35108370.
8. Bai C, Wang J, Mondal D, Du Y, Ye RD, Warshel A. Exploring the Activation Process of the β2AR-Gs Complex. Journal of American Chemical Society. 2021 Jul 28;143(29):11044-11051. doi: 10.1021/jacs.1c03696. Epub 2021 Jul 13. PMID: 34255502.
9. Zhang S, Gong H, Ge Y, Ye RD. Biased allosteric modulation of formyl peptide receptor 2 leads to distinct receptor conformational states for pro- and anti-inflammatory signaling. Pharmacological Research. 2020 Aug 5;161:105117. doi: 10.1016/j.phrs.2020.105117. Epub ahead of print. PMID: 32768626.
10. Cheng N, Liang Y, Du X, Ye, RD. Serum amyloid A promotes LPS clearance andsuppresses LPS-induced inflammation and tissue injury. EMBO Reports 2018 Oct;19(10). pii: e45517; doi: 10.15252/embr.201745517. PMID: 30126923.