杜鹃

助理院长（教育）
校长青年学者

副教授

教育背景

生理学博士（香港中文大学）

生理学硕士（安徽医科大学）

临床医学学士（佳木斯大学医学院）

学术领域
临床医学
研究领域
主要基于头颈癌、结直肠癌、呼吸与血管系统疾病等开展以下研究：1）钙信号与肿瘤细胞外囊泡分泌机制； 2）外泌体及囊泡靶向载药在疾病精准治疗中的应用； 3）基于外泌体与多组学联合分析的疾病诊疗标记物筛选； 4）聚集诱导发光分子等化学分子与材料在抗菌、抗肿瘤治疗中的应用
电子邮件
dujuan@cuhk.edu.cn
个人简介

杜鹃教授于2000年获得佳木斯大学医学院临床医学学士学位；2004年获得安徽医科大学生理学硕士学位；2005-2006年，在美国北德克萨斯大学卫生科学中心做访问学者；2011年获得香港中文大学生理学博士学位。2004-2020年，曾任安徽医科大学生理学教授、基础医学院副院长、基础医学国家级虚拟仿真实验教学中心主任。2020年7月加入香港中文大学（深圳）参与医学院筹建工作，现任香港中文大学（深圳）医学院长聘副教授与助理院长。

科研兴趣主要是钙信号与细胞功能、肿瘤外泌体分泌机制，外泌体在肿瘤早期诊断中的应用、外泌体靶向载药等，先后主持国家自然科学基金项目4项、其他科研项目20余项，在JASN，Theranostics，ACS Nano，iMeta等杂志发表SCI论文80余篇，获得省级科技成果奖三等奖1项。

同时致力于医学教育、教学改革研究和学生创新能力培养，主持教育部产学合作协同育人项目、省重大教改项目、省MOOC示范项目等近10项教学课题，荣获安徽省教学名师，获得省教学成果奖3项。发表教学论文20余篇，作为主编、副主编等参与《精解生理学》ESP版形态数字化教材、《生理学》、《基础医学整合实验》等10余部教材编写，指导本科生获得医学生理学知识竞赛国际赛亚军及国内赛冠军、“互联网+”大学生创新创业大赛国赛铜奖及省赛金奖等各类获奖20余项。

学术著作

部分学术著作

  1. Suwen Bai, Zunyun Wang, Yuxin Zhang, Yuanyuan Yang, Yuan Wei, Yumei Luo, Minghua Wang, Bing Shen, Wei He, Zhenye Zhang*, Hui Hui*, Du Juan*. iRGD-TRP-PK1-modified red blood cell membrane vesicles as a new chemotherapeutic drug delivery and targeting system in head and neck cancer. Theranostics. 2025 Jan 1;15(1):86-102. 

  2. Zunyun Wang, Yan Ren, Yicong Li, Yuxin Zhang, Suwen Bai, Wenxuan Hou, Wenjun Zhang, Yanheng Yao, Hongxian Zhao, Minghua Wang, Yumei Luo, Gang Pang*, Juan Du*. MiR-186-5p carried by M2 macrophage-derived exosomes downregulates TRPP2 expression in airway smooth muscle to alleviate asthma progression. Int Immunopharmacol. 2025 Feb 20;148:114107.

  3. Siwei zhang, Ming Shao, Yuan Wu, Fulong Ma, Chao Chen*, Juan Du*, Zheng Zhao*, Benzhong Tang*. Novel [3+2+1] Coordinated Iridium (Ⅲ) Complexes for Hyperefficient Photodynamic Therapy. Aggregate, 2025, January; 0: e710. 

  4. Yuexin Yang, Tianhui Sun, Hailan Wu, Zhiwei Chen, Yan Sun, David W CHAN, Bangning Cheng, Xiaorong Zhan*, Juan Du*. Rapid recovery from diabetic ketoacidosis and hyperglycemic hyperosmolar state in two patients with severe hyperglycemia. iLAB. 2025, 3(1): 90-95.

  5. Yang Wang, Qiu-Long Zhang, Yan Liu, Liang-Liang Wang, Chao-Qun Wu, Ming Shao, Xiwen Xing, Juan Du*, Liang Xu*. Photo-controllable multiple and orthogonal regulation of gene expression by chemically modified oligonucleotides. Science china chemistry. 2025; 68(2):694-704.

  6. Ying Peng, Rufan Mo, Mingwang Yang, Huilin Xie, Fulong Ma, Zeyang Ding, Song Wu, Jacky W Y Lam, Juan Du*, Jianquan Zhang*, Zheng Zhao*, Ben Zhong Tang*. Mitochondria-Targeting AIEgens as Pyroptosis Inducers for Boosting Type-I Photodynamic Therapy of Tongue Squamous Cell Carcinoma. ACS Nano. 2024 Sep 13. 18:26140-26152.

  7. Ming Shao, Yunran Gao, Xiling Xu, Jiyuan Shi, Zunyun Wang, Juan Du*. Expediting the development of robust 5-FU-resistant colorectal cancer models using innovative combined in vivo and in vitro strategies. Biomed Pharmacother. 2024, November;180:117576.

  8. Yanheng Yao, Yuxin Zhang, Jiyuan Shi, Xiling Xu, Yunran Gao, Suwen Bai, Qin Hu*, Jing Wu*, Juan Du*. LncRNA PART1 promotes malignant biological behaviours associated with head and neck cancer cells via synergistic action with FUT6. Cancer Cell Int. 2024 May 28;24(1):185. 

  9. Ming Shao, Yunran Gao, Xiling Xu, David Wai Chan, Juan Du. Exosomes: Key Factors in Ovarian Cancer Peritoneal Metastasis and Drug Resistance. Biomolecules. 2024;14(9):1099. 

  10. Jingyue Chang, Lingquan Zhang, Zeting Li, Chungen Qian*, Juan Du*. Exosomal non-coding RNAs (ncRNAs) as potential biomarkers in tumor early diagnosis. Biochim Biophys Acta Rev Cancer. 2024;1879(6):189188. 

  11. Yang Wang, Chao-Qun Wu, Qiu-Long Zhang, Ming Shao, Yan Liu, Liang-Liang Wang, Zun-Yun Wang, Juan Du*, Liang Xu*. Switching On/Off of Guide RNA by Photo-Induced Strand Displacement for Functional Control of CRISPR/Cas9. CCS Chemistry. 2023; 61: 1-141.

  12. Jialin Meng, Aimin Jiang, Xiaofan Lu, Di Gu, Qintao Ge, Suwen Bai, Yundong Zhou, Jun Zhou, Zongyao Hao, Fangrong Yan, Linhui Wang, Haitao Wang, Juan Du*, Chaozhao Liang*. Multi-omics characterization and verification of clear cell renal cell carcinoma molecular subtypes to guide precise chemotherapy and immunotherapy. iMeta. 2023,e147. 

  13. Suwen Bai, Yuan Wei, Rong Liu, Yuhua Chen, Wanling Ma, Minghua Wang, Li Chen, Yumei Luo*, Juan Du*. The role of transient receptor potential channels in metastasis. Biomed Pharmacother. 2023; 158:114074.

  14. Suwen Bai, Zunyun Wang, Minghua Wang, Juanai Li, Yuan Wei, Ruihuan Xu, Juan Du*. Tumor-Derived Exosomes Modulate Primary Site Tumor Metastasis. Front Cell Dev Biol. 2022 Mar 2;10:752818.

  15. Huake Cao, Yuechen Wang, Ning Zhang, Siyuan Xia, Pengfei Tian, Li Lu, Juan Du*, Yinan Du*. Progress of CRISPR-Cas13 Mediated Live-Cell RNA Imaging and Detection of RNA-Protein Interactions. Front Cell Dev Biol. 2022 Mar 9;10:866820.

  16. Jialin Meng, Yonghao Chen, Xiaofan Lu, Qintao Ge, Feixiang Yang, Suwen Bai, Chaozhao Liang*, Juan Du*. Macrophages and monocytes mediated activation of oxidative phosphorylation implicated the prognosis and clinical therapeutic strategy of Wilms tumour. Comput Struct Biotechnol J. 2022 Jun 27;20:3399-3408.

  17. Suwen Bai, Yuan Wei, Rong Liu, Rruihuan Xu, Li Xiang, Juan Du. Role of tumour-derived exosomes in metastasis. Biomed Pharmacother. 2022 Jan 22;147:112657.

  18. Suwen Bai, Wenxuan Hou, Yanheng Yao, Jialin Meng, Yuan Wei, Fangfang Hu, Xianyu Hu, Jing Wu, Ning Zhang, Ruihuan Xu, Faqing Tian, Benguo Wang, Hailan Liao, Yinan Du, Haoshu Fang, Wei He, Yehai Liu, Bing Shen, Juan Du*. Exocyst controls exosome biogenesis via Rab11a.. Molecular Therapy-Nucleic Acids. Mol Ther Nucleic Acids. 2021; 27: 535-546. 

  19. Xianyu Hu, Zhenglin Wang, Qing Wang, Ke Chen, Qijun Han, Suwen Bai, Juan Du*, Wei Chen*. Molecular classification reveals the diverse genetic features and prognosis of gastric cancer: a multi-omics consensus ensemble clustering. Biomedicine & Pharmacotherapy. 2021; 144: 112222.

  20. Yuan Wei, Suwen Bai, Yanheng Yao, Wenxuan Hou, Fangfang Hu, Yinan Du, Wei He, Bing Shen, Juan Du*. Orai-VE-cadherin signaling complex regulates high-glucose exposure–induced increased permeability of mouse aortic endothelial cells. BMJ Open Diabetes Research&Care. 2021; 9(1): e002085. 

  21. Suwen Bai, Yuan Wei, Wenxuan Hou, YanHeng Yao, Junwei Zhu, Xianyu Hu, Wei Chen, Yinan Du, Wei He, Bing Shen*, Juan Du*. Orai- IGFBP3 Signaling Complex Regulates High-Glucose Exposure-Induced Increased Proliferation, Permeability, and Migration of Human Coronary Artery Endothelial Cells. BMJ Open Diabetes Research&Care. 2020, 8(1): e001400.

  22. Ning Zhang, Xianyu Hu, Yinan Du*, Juan Du*. The role of miRNAs in colorectal cancer progression and chemoradiotherapy. Biomedicine & Pharmacotherapy. 2020, 134, 111099

  23. Yuan-Yuan Huang, Jing Li, He-Rui Zhang, Su-Wen Bai, Hui-Yun Yang, Bing Shen, Juan Du*, Xian-Ming Xia* . The Effect of Transient Receptor Potential Vanilloid 4 on the Intestinal Epithelial Barrier and Human Colonic Cells was Affected by Tyrosine-Phosphorylated Claudin-7. Biomedecine & pharmacotherapie. 2020, 122:109697.

  24. Jie Zhang, Yuan Wei, Suwen Bai, Shenggang Ding, Huiwen Gao, Sheng Yin, Shuo Chen, Jinsen Lu, Haoran Wang, Yonggang Shen, Bing Shen, Juan Du*. TRPV4 Complexes With the Na+/Ca2+ Exchanger and IP3 Receptor 1 to Regulate Local Intracellular Calcium and Tracheal Tension in Mice. Frontiers in Physiology. 2019, 10: 1471. 

  25. Dacheng Sang, Suwen Bai, Sheng Yin, Sen Jiang, Li Ye, Wenxuan Hou, Yanheng Yao, Haoran Wang, Yonggang Shen, Bing Shen, Juan Du*. Role of TRPP2 in Mouse Airway Smooth Muscle Tension and Respiration. Am J Physiol Lung Cell Mol Physiol. 2019, 317(4): L466-L474.

  26. Jing-Si Duan, Shuo Chen, Xiao-Qing Sun, Juan Du*, Zhi-Wu Chen*. Urotensin-#Receptor Antagonist SB-706375 Protected Isolated Rat Heart from Ischaemia-Reperfusion Injury by Attenuating Myocardial Necrosis via RhoA/ROCK/RIP3 Signalling Pathway. Inflammopharmacology. 2019, 27(6): 1309-1318.

  27. Dezhi Yu, Yang Fang, Menglan Xu, Jinhang Zhu, Kun Li, Kaile Wu, Chuyan Wang, Bing Shen, Juan Du*, Yehai Liu. Tumor Necrosis Factor a Promotes Hep-2 cell Proliferation via Toll-Like Receptor 4 and NF-kB Signaling Pathways. Int J Clin Exp Pathol. 2017; 10(12):11666-11672.

  28. Jing Wu，Jizheng Guo，Yunyun Yang，Feifei Jiang，Shuo Chen，Kaile Wu，Bing Shen，Yehai Liu，Juan Du. Tumor Necrosis Factor ɑ accelerates Hep-2 Cells Proliferation by Suppressing TRPP2 Expression. Sci China Life Sci. 2017, 60(11): 1251-1259.

  29. Juan Du, Xia Wang, Jie Li, Jizheng Guo, Limei Liu, Dejun Yan, Yunyun Yang, Zhongwen Li, Jinhang Zhu，Bing Shen. Increasing TRPV4 Expression Restores Flow-Induced Dilation Impaired in Mesenteric Arteries with Aging. Sci Rep. 2016, 6: 22780.

  30. Juan Du, Jie Fu, Xian-ming Xia，Bing Shen. The Functions of TRPP2 in the Vascular System. Acta Pharmacol Sin. 2016; 37(1):13-18.

  31. Xingguo Zhong ,Jie Fu，Kai Song，Nairui Xue，Renhua Gong，Dengqun Sun，Huilai Luo，Wenzhu He，Xiang Pan，Bing Shen，Juan Du. The Role of TRPP2 in Agonist-Induced Gallbladder Smooth Muscle Contraction. Sci China Life Sci. 2016, 59(4):409-416.

  32. Bing Shen, Jie Fu, Jizheng Guo, Jie Zhang, Xia Wang, Xiang Pan, Meihua Chen, Yifan Zhou, Min Zhu, Juan Du. Role of Na+-K+-2Cl- Cotransporter 1 in Phenylephrine-Induced Rhythmic Contraction in the Mouse Aorta: Regulation of Na+-K+-2Cl- Cotransporter 1 by Ca2+ Sparks and KCa Channels. Cell Physiol Biochem. 2015, 37(2): 747-758.

  33. Juan Du, Xin Ma, Bing Shen, Yu Huang, Lutz Birnbaumer, Xiaoqiang Yao. TRPV4, TRPC1, and TRPP2 Assemble to Form a Flow-Sensitive Heteromeric Channel. FASEB J. 2014, 28(11):4677-4685.

  34. Zhiqiang Yu, Jie Li, Jinhang Zhu, Min Zhu, Feifei Jiang, Jin Zhang, Zhongwen Li, Mingkui Zhong, Justin Boy Kaye, Juan Du*, Bing Shen*. A Synthetic Transmembrane Segment Derived from TRPV4 Channel Self-Assembles into Potassium-like Channels to Regulate Vascular Smooth Muscle Cell Membrane Potential. J. Mater. Chem. B, 2014, 2, 3809-3818.

  35. Bing Shen, Jinhang Zhu, Jin Zhang, Feifei Jiang, Zhaoyi Wang,Yang Zhang, Jie Li, Dake Huang, Daoping Ke, Rong Ma, Juan Du. Attenuated Mesangial Cell Proliferation Related to Store-Operated Ca2+ entry in Aged Rat: the Role of STIM 1 and Orai1. Age . 2013, 35(6):2193-2020.

  36. Xin Ma#, Juan Du#, Peng Zhang, Jianxin Deng, Jie Liu, Francis Fu-Yuen Lam, Ronald A Li, Yu Huang, Jian Jin, Xiaoqiang Yao. Functional Role of TRPV4-KCa2.3 Signaling in Vascular Endothelial Cells in Normal and Streptozotocin-Induced Diabetic Rats. Hypertension. 2013, 62(1): 134-139.

  37. Juan Du, Wei-Yan Wong, Lei Sun, Yu Huang, Xiaoqiang Yao. Protein Kinase G Inhibits Flow-Induced Ca2+ Entry into Collecting Duct Cells. J Am Soc Nephro, 2012, 23(7): 1172-1180.

  38. Juan Du, Min Ding, Sherry Sours-Brothers, Sarabeth Graham, Rong Ma. Mediation of Angiotensin II Ca2+ Signaling by Polycystin 2 in Glomerular Mesangial Cells. Am J Physiol Renal Physiol, 2008, 294(4): F909-918.

  39. Juan Du, Sherry Sours-Brother, Coleman Rashadd, Min Ding, Sarabeth Graham, Dehu Kong DH, Rong Ma. Canonical Transient Receptor Potential 1 Channel is Involved in Contractile Function of Glomerular Mesangial Cells. J Am Soc Nephrol, 2007, 18(5): 1437-1445.