白芸

副教授(教学)

教育背景

博士(南加州大学)

硕士(清华大学)

学士(北京大学)

研究领域
蛋白药制剂、组合蛋白药物、大分子药物口服与透皮吸收、使用转录组、小RNA组、蛋白质组的系统毒理学
电子邮件
baiyun@cuhk.edu.cn
个人简介

白芸博士在香港中文大学(深圳)医学院担任副教授(教学)。白芸博士在北京大学健康科学中心获得药学学士学位,在清华大学获得生物化学和分子生物学硕士学位,在美国南加州大学获得药剂学博士学位。在加入香港中文大学(深圳)之前,白博士曾在美国费城骨科医学院药物科学系任副教授。

目前白博士有24篇科研文章发表,其中包括一些影响较大的科学期刊,例如PNAS、《药物研究》等。她拥有一项美国专利。她的研究领域包括蛋白质、多肽药物的口服和透皮递送,重组融合蛋白的开发,使用传统药理学方法和基因组学工具对药物不良反应的机理研究。

学术著作
  1. Francis CE, Bai Y (2018) Differential Expression of Cyclosporine A-Induced Calcineurin Isoform-Specific Matrix Metalloproteinase 9 (MMP-9) in Renal Fibroblasts. Biochem Biophys Res Commun. 2018 Sep 18;503(4):2549-2554. doi: 10.1016/j.bbrc.2018.07.014. Epub 2018 Jul PMID: 30007437
  2. Lu J, Lu Y, Ding Y, Xiao Q, Liu L, Cai Q, Kong Y, Bai Y* and Yu*. (2018) Detecting Differential Consistency Genes and Network Modules. International Symposium on Bioinformatics Research and Applications (ISBRA) (Accepted) (* Joint correspondence authors)
  3. Gooch JL, King C, Francis CE, Garcia PS, Bai Y.(2017) Cyclosporine A alters expression of renal microRNAs: New insights into calcineurin inhibitor nephrotoxicity. PLoS One. 2017 Apr 17;12 (4):e0175242
  4. Yan Y*, Qiu S*, Jin Z, Gong S, Bai Y#, Lu J#, Yu T# (2017) Detecting subnetwork-level dynamic correlations. Bioinformatics. (2017) Jan 15;33(2):256-265. doi: 10.1093/bioinformatics/btw616. Epub 2016 Sep 25.PMID:27667792(*Joint first authors, # Joint correspondence authors)
  5. Peng H, Ma J, Bai Y, Lu J, Yu T. (2015) MeDiA: Mean Distance Association and Its Applications in Nonlinear Gene Set Analysis. PLoS One. 2015 Apr 27;10(4) e0124620
  6. Yu T, Bai Y (2014) Network-based modular latent structure analysis. BMC Bioinformatics. 2014;15 Suppl 13:S6.
  7. Yang R, Bai Y, Qin Z, Yu T (2014) EgoNet: identification of human disease ego-network modules, BMC Genomics Apr 28;15:314.
  8. Bai Y, Kim Y, Banga, Aj (2014) Transdermal delivery of proteins using a combination of iontophoresis and microporation. Therapeutic Delivery May; 5(5):525-36
  9. Sachdeva V, Bai Y, Kydonieus A, Banga AK. (2013) Formulation and optimization of desogestrel transdermal contraceptive patch using crystallization studies. Int J Pharm. 441(1-2):9-18.
  10. Yu T, Bai Y. (2013) Analyzing LC/MS Metabolic Profiling Data in the Context of Existing Metabolic Networks. Current Metabolomics. 1(1): 84-91.
  11. Vemulapalli V, Bai Y, Kalluri H, Herwadkar A, Kim H, Davis SP, Friden PM, Banga AK. (2013) In vivo iontophoretic delivery of salmon calcitonin across microporated skin. J Pharm Sci. 101(8):2861-9
  12. Yu T#Bai Y#. (2011) Improving gene expression data interpretation by finding latent factors that co-regulate gene modules with clinical factors. BMC Genomics. 12:563. (joint correspondence author)
  13. Yu T#Bai Y#. (2011) Capturing Changes in Gene Expression Dynamics by Gene Set Differential Coordination Analysis. Genomics. 98(6):469-77. (joint correspondence author)
  14. Chen X, Bai Y, Zaro J, Shen WC. (2010) Design of an in vivo cleavable disulfide linker in recombinant fusion proteins. Biotechniques. 49(1): 513-8.
  15. Bai Y, Shen WC. (2006) Improving the oral efficacy of recombinant granulocyte colony-stimulating factor and transferrin fusion protein by spacer optimization. Pharm Res. 23(9):2116-21.
  16. Bai Y, Ann DK, Shen WC. (2005) Recombinant granulocyte colony-stimulating factor-transferrin fusion protein as an oral myelopoietic agent. Proc Natl Acad Sci U S A. 102(20):7292-6.
  17. Widera A, Bai Y, Shen WC. (2004) The transepithelial transport of a G-CSF-transferrin conjugate in Caco-2 cells and its myelopoietic effect in BDF1 mice. Pharm Res. 21(2):278-84.
  18. Bai Y, Zhao Y, Yu T, Dierich MP, Chen YH. (2000) Antibodies to HIV-1 gp41 recognize synthetic peptides of human IFN-alpha and IFN-beta.  Int Arch Allergy Immunol. 121(2): 170-2.
  19. Yu T, Bai Y, Dierich MP, Chen YH. (2000) Induction of high levels of epitope-specific antibodies by epitope/peptide candidate vaccines against human immunodeficiency virus type-1 (HIV-1). Microbiol Immunol. 44(2): 105-10.
  20. Yu T, Xiao Y, Bai Y, Ru Q, Luo G, Dierich MP, Chen Y. (2000) Human interferon-beta inhibits binding of HIV-1 gp41 to lymphocyte and monocyte cells and binds the potential receptor protein P50 for HIV-1 gp41. Immunol Lett. 73(1):19-22.
  21. Chen YH, Bai Y, Yu T, Dierich MP. (1999) Modulation of major histocompatibility complex antigen expression by human immunodeficiency virus-2 gp36. Immunol Lett. 68(2-3): 415-7.
  22. Chen YH, Yu T, Bai Y, Dierich MP. (1999) Immunogenicity of the GPGRAFY epitope on synthetic peptides. Immunol Lett. 69(3): 353-4.
  23. Chen YH, Yu T, Bai Y, Zhao N. (1999) Two proteins share immunological epitopes on the tumor-associated antigen 17-1A. Cancer Lett. 144(1): 101-5.
  24. Bai Y, Yu T, Zhao Y, Xiao Y, Yang Y, Chen YH. (1999) A novel putative tumor associated antigen. Tsinghua Sci. & Tech. 4(3): 1568-9.