博士 (中国科学技术大学)

学士 (中南大学湘雅医学院)

杜洋教授于中南大学湘雅医学院和中国科大取得学士和博士学位后，赴美国斯坦福大学医学院，师从2012年诺贝尔化学奖得主布莱恩·科比尔卡(Brian Kobilka)教授，从事G蛋白偶联受体(GPCR)博士后研究，后担任斯坦福医学中心研究科学家，也获得美国密歇根大学安娜堡分校医学院助理教授职位。迄今已发表近80篇高质量论文，其主要方向是对心脑肠轴特异分布的重要GPCR进行结构功能研究，并针对神经精神疾病从事创新药物发现。现承担十几项国家等各级科研项目，并与多家上市医药公司开展技术攻关合作。

近年来以通讯或第一作者在Cell、Science、STTT、Cell Res、APSB、Nature Comm、Science Adv、Cell Dist、JACS、Cell Rep、PLoS Biol和PNAS等国际期刊报道了一系列科研成果，并受邀为Science、Cell Res和Nature Comm等多种一流期刊审稿。现为医学院长聘(tenured)副教授(正高)，科比尔卡创新药物开发研究院研究员，新医学研究院院长。曾获得深圳市优秀教师、校长模范教学奖和大学青年科研创新奖等荣誉；入选英国皇家医学会会士，国家级特聘专家和珠江青年拔尖人才等；担任北京协和医院内分泌科客座教授、中华医学会骨质疏松和骨矿盐疾病分会遗传性骨病学组副组长和中华医学会航海医学转化副主委等。

36 Pan X*, Ye F*, Ning P*, Yu Y*, Zhang Z, Wang J, Chen G, Wu Z, Qiu C, Li J, Chen B, Zhu L#, Qian C#, Gong K#, Du Y#. Structures of G-protein coupled receptor HCAR1 in complex with Gi1 protein reveal the mechanistic basis for ligand recognition and agonist selectivity. PLOS Biol. 2025 Apr 15;23(4):e3003126
35 Li S*, Ye F*, Zheng Y*, Wang J*, Peng H*, Zhu L, Chen L, Yu T, Ge H, He J, Zhang B, Wu J, Zhang Z, Jiang L, Chen G, Zhang P, Lan K, Zhao Z, Qian X, Xu K#, Du Y#, Li H#. Dual-Locking the SARS-CoV-2 Spike Trimer: An Amphipathic Molecular "Bolt" Stabilizes Conserved Druggable Interfaces for Coronavirus Inhibition. Adv Sci. 2025 Jul;12(27):e2417534
34 Wu Z*, Qiu C*, Liu Y*, Yan X, Li Q, Jiang S, Xu J, Pan X, Ye F, Zhang Z, Ning P, Zhang B, Xu L, Cheng B, Xiang X, Qian C#, Du Y#, Chen G#. Structural insights into prolactin-releasing peptide receptor signaling and G-protein coupling selectivity. Cell Rep. 2025 Feb 19;44(3):115337
33 Zeng Z*, Liao Q*, Gan S*, Li X, Xiong T, Xu L, Li D, Jiang Y, Chen J#, Ye R#, Du Y#, Wong T#. Structural Insights into the Binding Modes of Lanreotide and Pasireotide with Somatostatin Receptor 1. Acta Pharm Sin B, 2025 May;15(5):2468-2479
32 Ye F*, Pan X*, Zhang Z*, Xiang X*, Li X*, Zhang B, Ning P, Liu A, Wang Q, Gong K, Li J, Zhu L#, Qian C#, Chen G#, Du Y#. Structural basis for ligand recognition of the human hydroxycarboxylic acid receptor HCAR3. Cell Rep. 2024 Nov 26;43(11):114895
31 Wu Z*, Chen G*, Qiu C*, Yan X, Xu L, Jiang S, Xu J, Han R, Shi T, Liu Y, Gao W, Wang Q, Li J, Ye F, Pan X, Zhang Z, Ning P, Zhang B, Chen J#, Du Y#. Structural basis for the ligand recognition and G-protein subtype selectivity of kisspeptin receptor. Science Adv, 2024, Aug 16;10(33)
30 Liu A*, Liu Y*, Chen G*, Lyu W*, Ye F, Wang J, Liao Q, Zhu L#, Du Y#, Ye RD#, Structure of G protein-coupled receptor GPR1 bound to full-length chemerin adipokine reveals a chemokine-like reverse binding mode. PLOS Biology, 2024, Oct 28;22(10):e3002838
29 Xu J*, Chen G*, Wang H, Cao S, Heng J, Deupi X, Du Y#, Kobilka BK#. Calcineurin-fusion facilitates Cryo-EM Structure Determination of a Family A GPCR. PNAS, 2024, Nov 26;121(48):e2414544121
28 Ham D, Inoue A, Xu J, Du Y#, Chung KY#. Molecular mechanism of muscarinic acetylcholine receptor M3 interaction with Gq. Commun Biol. 2024 Mar 23;7(1):362
27 Chen G*, Staffen N*, Wu Z, Xu X, Pan J, Inoue A, Shi T, Gmerner P, Du Y#, Xu J#. Structural and functional characterization of the endogenous agonist for orphan receptor GPR3. Cell Res, 2024 Mar;34(3):262-265
26 Zhou D, Huang J, Zheng H, Liu Y, Zhu S, Du Y#. Insight into Fructose-to-Sucrose Ratio as the Potential Target of Urinalysis in Bladder Cancer. Metabolites, 2024 (14), 345
25 Pan X*, Ye F*, Ning P, Zhang Z, Li X, Zhang B, Wang Q, Chen G, Gao W, Qiu C, Wu Z, Li J, Zhu L, Xia J#, Gong K#, Du Y#. Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2. Cell Dis, 2023 Nov 28;9(1):118
24 Xu J*, Wang Q*, Hubner H, Niu X, Wang H, Maeda S, Inoue A, Tao Y, Gmerner P, Du Y#, Jin C#, Kobilka BK#. Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor. Nature Commun., 2023 Jan 23;14(1):376
23 Xu J, Cao S, Hubner H, Weikert D, Chen G, Lu Q, Yuan D, Gmerner P#, Liu Z#, Du Y#. Structural insights into ligand recognition, activation and signaling bias of the α2A adrenergic receptor. Science Advances, 2022, Mar 4;8(9):eabj5347
22 Chen G, Xu J, Inoue A, Schmidt MF, Bai C, Lu Q, Gmerner P#, Liu Z#, Du Y#. Structure of the orphan GPR88-Gi complex reveals unique ligand binding and signaling mechanism. Nature Commun., 2022, May 2;13(1):2375
21 Wang Q*, Lu Q*, Guo Q, Teng M, Gong Q, Li X, Du Y#, Liu Zheng#, Tao Y#. Structural basis of the ligand binding and signaling mechanism of melatonin receptors. Nature Commun., 2022 Jan 24;13(1):454.
20 Flink EA*, Xu J*, Hubner H*, Braz J*, Seemann P*, Avet C, Craik V, Weikert D, Schmidt MF, Webb CM, Tolmachova NA, Moroz Y, Huang XP, Kalyanaraman C, Gahbauer S, Chen G, Liu Z, Jacobson MP, Irwin JJ, Mouvier M, Du Y#, Schoichet BK#, Basbaum AI#, Gmerner P#. Structure-based discovery of nonopioid analgesics acting through the α2A-adrenergic receptor. Science, 2022 Sep 30;377(6614):eabn7065
19 Chen G, Wang X, Liao Q, Ge Y, Jiao H, Chen Q, Liu Y, Du Y#, Hu H#, Ye RD#. Structural Basis for Recognition of N-Formyl Peptides as Pathogen- and Damage- associated Molecular Patterns. Nature Commun., 2022 Sep 5;13(1):5232
18 Wong TS*, Li G*, Li S*, Gao W, Chen G, Gan S, Zhang M, Li H#, Wu S#, Du Y#. G protein-coupled Receptors in Nervous System and Neuropsychiatric Disorders. Signal Transduct Target Ther., 2023, May 3;8(1):177. doi: 10.1038/s41392-023-01427-2
17 Wang J*, Chen G*, Liao Q*, Lyu W, Liu A, Zhu L, Du Y#, Ye RD#. Cryo-EM structure of the human chemerin receptor 1 – Gi protein complex bound to the C-terminal nonapeptide of chemerin. PNAS, 2023, Mar 14;120(11):e2214324120
16 Wong TS*, Gao W*, Chen G*, Qiu C*, He G, Ye F, Wu Z, Zeng Z, Du Y#. Cryo-EM structure of orphan G protein-coupled receptor GPR21. MedComm, 2023 Jan 25;4(1):e205
15 Ye F*, Wong TS*, Chen G*, Zhang Z, Zhang B, Gan S, Gao W, Li J, Wu Z, Pan X, Du Y#. Cryo‐EM structure of G‐protein‐coupled receptor GPR17 in complex with inhibitory G protein. MedComm, 2022 Sep 10;3(4):e159
14 Chen G*, Gao W, Du Y#. Identification of a Sialosides binding pocket in early- lineage Sars-Cov-2 virus via an optimized STD NMR method: a novel explanation for coronavirus virulence and zoonosis. Molecular Biomedicine, 2022 Oct 21;3(1):32
13 Xiao P*, Yan W*, Gou L*, Zhong YN*, Kong L*, Wu C, Wen X, Yuan Y, Qu C, Yang X, Zhang C, Xia A, Yang CC, Hou GH, Fu P, Yang S, Rosenbaum DM, Sun JP, Du Y#, Zhang L#, Yu X#, Shao Z#. Ligand recognition and allosteric regulation of dopamine D1 receptor-Gs signaling complexes. Cell, 2021, 184(4):943-956
12 Wang L*, Xu J*, Cao S, Sun D, Liu H, Liu Z, Du Y#, Zhang C#. Cryo-EM structure of the AVP-vasopressin receptor 2-Gs signaling complex. Cell Research, 2021 Aug;31(8):932-934
11 Kim HR*, Xu J*, Maeda S, Duc NM, Ahn D, Du Y#, Chung KY. Structural mechanism underlying primary and secondary coupling between GPCRs and the Gi/o family. Nat Commun. 2020 Jun 22;11(1):3160
10 Bai C#, Wang J, Chen G, Zhang H, Xu P, Du Y#, Ye RD#, Saha A, Zhang A, Warshel A#. Predicting Mutational Effects on Receptor Binding of the SARS-CoV-2 Variants. J Am Chem Soc., 2021, 143, 42, 17646–654
9 Du Y*, Duc NM*, Rasmussen SGF*, Hilger D, Kubiak X, Wang L, Kim HR, Wegrecki M, Asuru A, Jeong KM, Lee J, Chance M, Lodowski DT, Kobilka BK, Chung KY. Assembly of a GPCR-G protein complex. Cell (2019) 177(5):1232-1242
8 Komolov KE*, Du Y*, Duc NM, Betz R, Rodrigues J, Leib RD, Patra D, Skiniotis G, Adams CM, Dror R, Chung KY, Kobilka BK, Benovic JL. Structural and functional analysis of a β2-Adrenergic Receptor Complex with GRK5. Cell (2017) 169: 407-421
7 Das M*, Du Y*, Ribeiro O, Hariharan P, Mortensen JS, Patra D, Skiniotis G, Loland CJ, Guan L, Kobilka BK, Byrne B, Chae, PS. Conformationally preorganized diastereomeric norbornane-based maltosides (NBMs) for membrane protein study: Implications of detergent kink for micellar properties. J. Am. Chem. Soc. (2017) 139: 3072-81
6 Ehsan M*, Du Y*, Scull NJ, Tikhonova E, Tarrasch J, Mortensen JS, Loland CJ, Skiniotis G, Guan L, Byrne B, Kobilka BK, Chae PS. Highly Branched Penta-Saccharide-Bearing Amphiphiles for Membrane Protein Studies. J. Am. Chem. Soc. (2016) 138: 3789-96
5 Sadaf A*, Du Y*, Hariharan P, Mortensen JS, Perez IM, Seven AB, Santillan C, Skiniotis G, Loland CJ, Kobilka BK, Guan L, Byrne B, Chae PS. Dendronic trimaltoside amphiphiles (DTMs) for membrane protein structure study. Chemical Science (2017) 8: 1169-1177
4 Duc NM*, Du Y*, Thorsen TS, Lee SY, Zhang C, Kato H, Kobilka BK, Chung KY. Effective Application of Bicelles for Conformational Analysis of G Protein-Coupled Receptors by Hydrogen/Deuterium Exchange Mass Spectrometry. J. Am. Soc. Mass. Spectrom. (2015) 26: 808-817
3 Du Y*, Shi WW*, He YX, Yang YH, Zhou CZ, Chen Y. Structures of the substrate-binding protein provide insights into the multiple compatible solutes binding specificities of Bacillus subtilis ABC transporter OpuC. Biochemical J. (2011) 436: 283-289
2 Du Y*, He YX*, Zhang ZY, Yang YH, Shi WW, Frolet C, Di Guilmi AM, Vernet T, Zhou CZ, and Chen Y. Crystal structure of the mucin-binding protein of Spr1345 from Streptococcus pneumoniae. J. of Struct. Biol. 2011, 174: 252-257
1 Du Y, He YX, Gaowa S, Zhang X, Chen Y, Zhang SC, Zhou CZ. Crystal structures of the apo and GDP-bound forms of a cupin-like protein BbDUF985 from Branchiostoma belcheri tsingtauense. Proteins. 2010, 78(12): 2714-9