STJEPANOVIC, Goran
助理教授
生物化学与生物物理学博士（海德堡大学自然科学与数学系）
分子生物学硕士（萨格勒布大学自然科学与数学系）
Goran STJEPANOVIC教授于克罗地亚萨格勒布大学分子生物学专业获得学士学位，他的本科毕业论文研究了人类低密度脂蛋白的氧化以及他们在动脉硬化发病机制中的角色。之后他在德国海德堡大学Irmgard Sinning实验室完成了他在结构生物学和膜生物化学的博士学习，他的研究关注跨细胞膜的蛋白质易位中的信号识别颗粒通道。博士毕业后，他加入了加利福尼亚大学伯克利分校James Hurley实验室，在那里他把分子生物学的技术与质谱分析法和生化调整结合来研究早期自噬体的形成。他的博士后工作重点是了解自噬特异性PI3-激酶和ULK1蛋白复合物的结构和调节机制。2018年，Goran加入香港中文大学（深圳）任助理教授与科比尔卡创新药物开发研究院研究员。
https://orcid.org/0000-0002-4841-9949
http://www.researcherid.com/rid/A-7902-2010
Selected Publications:
1. Stjepanovic, G., Baskaran, S., Lin, M.G., Hurley, J.H. Vps34 Kinase Domain Dynamics Regulate the Autophagic PI 3-Kinase Complex (2017) Molecular Cell, 67 (3), pp. 528-534.e3.
2. Stjepanovic, G., Baskaran, S., Lin, M.G., Hurley, J.H. Unveiling the role of VPS34 kinase domain dynamics in regulation of the autophagic PI3K complex (2017) Molecular and Cellular Oncology, 4 (6), art. no. e1367873.
3. Su, M.-Y., Morris, K.L., Kim, D.J., Fu, Y., Lawrence, R., Stjepanovic, G., Zoncu, R., Hurley, J.H. Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex (2017) Molecular Cell, 68 (5), pp. 835-846.e3.
4. Stjepanovic, G., Davies, C.W., Stanley, R.E., Ragusa, M.J., Kim, D.J., Hurley, J.H. Assembly and dynamics of the autophagy-initiating Atg1 complex (2014) Proceedings of the National Academy of Sciences of the United States of America, 111 (35), pp. 12793-12798.
5. Baskaran*, S., Carlson*, L.-A., Stjepanovic*, G., Young, L.N., Kim, do J., Grob, P., Stanley, R.E., Nogales, E., Hurley, J.H. Architecture and dynamics of the autophagic phosphatidylinositol 3-kinase complex (2014) eLife, 3, art. no. e05115. (* equal contribution)
6. Stjepanovic, G., Kapp, K., Bange, G., Graf, C., Parlitz, R., Wild, K., Mayer, M.P., Sinning, I. Lipids trigger a conformational switch that regulates Signal Recognition Particle (SRP)-mediated protein targeting (2011) Journal of Biological Chemistry, 286 (26), pp. 23489-23497.
7. Qi, S., Kim, D.J., Stjepanovic, G., Hurley, J.H. Structure of the human Atg13-Atg101 HORMA heterodimer: An interaction hub within the ULK1 complex (2015) Structure, 23 (10), pp. 1848-1857.
8. Yang, B., Stjepanovic, G., Shen, Q., Martin, A., Hurley, J.H. Vps4 disassembles an ESCRT-III filament by global unfolding and processive translocation (2015) Nature Structural and Molecular Biology, 22 (6), pp. 492-498.
