成贵娟
助理教授
博士（北京大学）
本科（华中科技大学）
成贵娟教授2010年从华中科技大学获得学士学位，2015年于北京大学获得物理化学博士学位，同年赴德国马克思-普朗克煤炭研究所（Max-Planck-Institut für Kohlenforschung）从事博士后研究。成教授于2018年7月加入香港中文大学（深圳），任职医学院及瓦谢尔计算生物研究院担任助理教授。研究兴趣主要包括疾病相关和生物合成相关的酶促反应机理研究、基于机理的药物设计和生物合成体系开发、有机反应机理研究等。迄今已发表60多篇高质量SCI论文，包括以第一或通讯作者（含共同）在Nature、Nat. Chem.、Nat. Comm.、Chem、JACS等国际一流期刊报道的一系列科研成果（总引用超过3000次，h-index 25），多篇论文入选ESI高被引论文和期刊封面；担任Nature Catalysis, Nature Communication等期刊特邀审稿人。获得中国化学会颁发的青年化学奖和物理有机化学新人奖；入选深圳市优青，广东省杰青和国家级人才项目。
1. Zhuang, J.; Yang, W.; Cheng, G.-J.* Mechanistic Insights into the Reversible Inhibition of D-Cycloserine in Alanine Racemase from Mycobacterium Tuberculosis. J. Chem. Inf. Model. 2025, 65, 2610.
2. Liang, T.#; Lyu, Z.#; Wang, Y.; Zhao, W.; Sang, R.; Cheng, G.-J.*; Ye, F.*, Light-promoted aromatic denitrative chlorination. Nat. Chem. 2025, doi.org/10.1038/s41557-024-01728.
3. Long, J.; Wang, T.; Zhong, H.; Jiao, M.; Morandi, B.; He, L.*; Cheng, G.-J.*; Fang, X*. One-Step Process for the Regiodivergent Double Hydrocyanation of 1,3-Butadiene. Angew. Chem. Int. Ed. 2025, 137, e202422337.
4. Wang, J.; Cheng, G.-J.*; Wong, H. N. C.; Peng, X.-S.* Computational Analysis of Diastereoselectivity and Carbene Reactivity in Pt- and Au-Catalyzed 1,5-Enyne Cycloisomerization to Bicyclo[3.1.0]Hexane. J. Org. Chem. 2025, 90, 3834.
5. Ni, J.; Zhuang, J.; Shi, Y.; Chiang, Y.-C.; Cheng, G.-J.* Discovery and Substrate Specificity Engineering of Nucleotide Halogenases. Nat. Commun. 2024, 15, 5254.
6. Zhan, X.; Nie, Z.; Li, N.; Zhou, A.; Lv, H.; Liang, M.; Wu, K.; Cheng, G.-J.*; Yin, Q.* Catalytic Asymmetric Cascade Dearomatization of Indoles via a Photoinduced Pd-Catalyzed 1,2-Bisfunctionalization of Butadienes. Angew. Chem. Int. Ed. 2024, 63, e202404388.
7. Long, J.; Wang, T.; Zhong, H.; Jiao, M.; Morandi, B.; He, L.; Cheng, G.-J.*; Fang, X.* One-Step Process for the Regiodivergent Double Hydrocyanation of 1,3-Butadiene. Angew. Chem. Int. Ed. 2024, e202422337.
8. Qu, R.; Wan, S.; Zhang, X.; Wang, X.; Xue, L.; Wang, Q.; Cheng, G.-J.*; Dai, L.*; Lian, Z.*, Mechanical-Force-Induced Non-spontaneous Dehalogenative Deuteration of Aromatic Iodides Enabled by Using Piezoelectric Materials as a Redox Catalyst. Angew. Chem. Int. Ed. 2024, 63, e202400645.
9. Yang, S.; Zhao, R.; Liu, D.; Jiang, H.; Cheng, G.-J.*; Wu, W.*, A visible-light-induced cascade cyclization strategy for the synthesis of N, S-containing polycyclic compounds. Org. Chem. Front. 2024, 11, 5067.
10. Zhou, Y.; Ni, J.; Lyu, Z.; Li, Y.; Wang, T.; Cheng, G.-J.*, Mechanism and Reaction Channels of Iron-catalyzed Primary Amination of Alkenes by Hydroxylamine Reagents. ACS Catal. 2023, 13,1863.
11. Yang, W.; Zhuang, J.; Chen, L.; Bai, C.*; Cheng, G.-J.*, Insights into the Inhibitory Mechanisms of the Covalent Drugs for DNMT3A. Int. J. Mol. Sci., 2023, 24, 12652.
12. Yang, W.; Zhuang, J.; Chen, L.; Cheng, G.-J.*, Unveiling the Methyl Transfer Mechanisms in the Epigenetic Machinery DNMT3A-3L: A Comprehensive Study Integrating Assembly Dynamics with Catalytic Reactions. Comput. Struct. Biotechnol. J., 2023, 21, 2086.
13. Long, J.; Zhao, R.; Cheng, G.-J.*, Fang, X.*, Palladium-Catalyzed Alkyne Hydrocyanation toward Ligand-Controlled Stereodivergent Synthesis of (E)- and (Z)-Trisubstituted Acrylonitriles. Angew. Chem. Int. Ed. 2023, 62, e202304543.
14. Xiong, B.; Zhang, J.; Wang, T.; Cheng, G.-J.*; Lian, Z.*, A palladium-catalyzed cross-electrophile coupling reaction involving sulfur dioxide for the direct synthesis of diversely functionalized sulfones. Org. Chem. Front., 2023, 10, 3567.
15. Zhou, H.; Zhou, Y.; Bae, H.; Leutzsch, M.; Li, Y.; De, C.; Cheng, G.-J.* and List B.* Organocatalytic stereoselective cyanosilylation of small ketones. Nature, 2022, 605, 84.
16. Zhou M, Wang T, Cheng, G.-J.*, Mechanistic insights into reductive deamination with hydrosilanes catalyzed by B(C6F5)3: A DFT study. Front Chem. 2022, 10: 1025135.
17. Chen, G.; Zhou, R.; Zhang, X.; Xiao, X.; Kramer, S.; Cheng, G.-J.*; Lian, Z.*, Carbonylative Cross-Electrophile Coupling between Aryl Bromides and Aryl Triflates Enabled by Palladium and Rhodium Cooperative Catalysis and CO as Reductant. ACS Catal. 2022, 12, 14582.
18. Zhao, R.; Zhang, B.-B., Liu, Z., Cheng, G.-J.*, and Wang Z.-X.* DFT Mechanistic Insights into Aldehyde Deformylations with Biomimetic Metal–Dioxygen Complexes: Distinct Mechanisms and Reaction Rules. JACS Au. 2022, 2, 745.
19. Long, J. #; Xia, S. #; Wang, T.; Cheng, G.-J.*; Fang, X.*, Nickel-Catalyzed Regiodivergent Cyanation of Allylic Alcohols: Scope, Mechanism, and Application to the Synthesis of 1,n-Dinitriles. ACS Catal. 2021, 11, 13880.
20. Sun, F.#; Wang, T.#; Cheng, G.-J.*; Fang, X.* Enantioselective Nickel-Catalyzed Hydrocyanative Desymmetrization of Norbornene Derivatives. ACS Catal. 2021, 11, 7578.
21. Sun, F.#; Yang, C.#; Ni, J., Cheng, G.-J.*; Fang, X.* Ligand-Controlled Regiodivergent Nickel-Catalyzed Hydrocyanation of Silyl-Substituted 1,3-Diynes. Org. Lett. 2021, 23, 4045.
22. Wang, T.; Zhou, Y.; Xu, Y.; Cheng, G.-J.,* Computational Exploration of Copper-Catalyzed Vinylogous Aerobic Oxidation of α,β- and β,γ-Unsaturated Compounds. Sci. Rep. 2021, 11, 1304.
23. Gao, J.#; Jiao, M.#; Ni, J.#; Yu, R.; Cheng, G.-J.*; Fang, X.* Diastereomeric Ligand-Controlled Regiodivergent Ni-Catalyzed Migratory Hydrocyanation of Internal Alkenes. Angew. Chem. Int. Ed. 2021, 60,1883.
24. Gao, J.#; Ni, J.#; Yu, R.; Cheng, G.-J.*; Fang, X.* Ni-Catalyzed Isomerization/Hydrocyanation Tandem Reactions: A Lewis Acid-Free Access to Linear Nitriles from Aliphatic Internal Olefins. Org. Lett. 2021, 23, 486.
25. Li, X.-T.; Lv, L.; Wang, T.; Gu, Q.-S. Xu, G.-X.; Li, Z.-L.; Ye, L.; Zhang, X.-H.; Cheng, G.-J.;* Liu, X.-Y.* Diastereo- and enantioselective catalytic radical oxysulfonylation of alkenes in β, γ-unsaturated ketoximes. Chem, 2020, 6, 1692.
26. Xiong, B.#; Wang, T.#; Sun, H.; Li, Y.; Kramer, S.; Cheng, G.-J.*; and Lian Z.* Nickel-Catalyzed Reductive Cross-Coupling Reactions for the Synthesis of gem-Difluorovinyl Arenes. ACS Catal. 2020. 10, 13616−13623.
27. Sun, F.#; Ni, J.#; Cheng, G.-J.*; Fang, X.* Highly regio- and stereoselective Ni-catalyzed hydrocyanation of 1,3-Enynes. Chem. Eur. J. 2020, 26, 5956.
28. Wang, L.#; Wang, T.#; Cheng, G.-J.; Li, X.; Wei, J.-J.; Guo, B.; Zheng, C.; Chen, G.; Ran, C.; Zheng, C., Direct C–H Arylation of Aldehydes by Merging Photocatalyzed Hydrogen Atom Transfer with Palladium Catalysis. ACS Catal. 2020, 7543-7551.
29. Deng, Y.; Zhao, C.; Zhou, Y.; Wang, H.; Li, X.; Cheng, G.-J.; Fu, J., Directing-group-based Strategy Enabling Intermolecular Heck-type Reaction of Cycloketone Oxime Esters and Unactivated Alkenes. Org. Lett. 2020, 2, 3524-3530.
30. Yang, C.; Li, P.; Ding, X.; Sui, C.; Rao, S.; Hsu, C.-H.; Leung, W.-P.; Cheng, G.-J.; Wang, P.; Zhu, B.; Mechanism for the Reactivation of the Peroxidase Activity of Human Cyclooxygenases: Investigation Using Phenol as a Reducing Cosubstrate. Sci. Rep. 2020, 10, 15187.
31. Yu, H.-J.; Zhao, W.; Zhou, Y.; Cheng, G.-J.; Sun, M.; Wang, L.; Yu, L.; Liang, S. H.; Ran, C., Salen-based bifunctional chemosensor for copper (II) ions: Inhibition of copper-induced amyloid-β aggregation. Analytica Chimica Acta, 2020, 8, 144.
32. Cheng, G.-J.*; Zhong, X.-M.; Wu, Y.-D.*; Zhang, X.*, Mechanistic understanding of catalysis by combining mass spectrometry and computation. Chem. Comm. 2019, 55, 12749.
33. Chen, Z.; Tang, J.-H.; Chen, W.; Xu, Y.; Wang, H.; Zhang, Z.; Sepehrpour, H.; Cheng, G.-J.; Li, X.; Wang, P.; Sun, Y.; Stang, P. J. Temperature and Mechanical Force Responsive Self-Assembled Rhomboidal Metallacycle, Organometallics 2019, 38, 21, 4244.
34. Ma, X.; Mai, S.; Zhou, Y.; Cheng, G.-J.; Song, Q. Dual Role of Ethyl Bromodifluoroacetate in the Formation of Fluorine-containing Heteroaromatic Compounds. Chem. Commun. 2018, 54, 8960.
