成贵娟

校长青年学者

助理教授

教育背景

博士(北京大学)

本科(华中科技大学)

研究领域
计算化学和生物学、酶催化和有机反应机理研究、药物设计、生物合成
电子邮件
chengguijuan@cuhk.edu.cn
个人简介

成贵娟教授2010年从华中科技大学获得学士学位,2015年于北京大学获得物理化学博士学位,同年9月赴德国马克思-普朗克煤炭研究所(Max-Planck-Institut für Kohlenforschung)从事博士后研究。成教授于2018年7月加入香港中文大学(深圳),现任职医学院及瓦谢尔计算生物研究院担任助理教授。研究兴趣主要包括疾病相关和生物合成相关的酶促反应机理研究、基于机理的药物设计和生物合成体系开发、有机反应机理研究等。迄今已发表30多篇高质量SCI论文,包括以第一或通讯作者(含共同)在Nature、Chem、JACS、Angew等国际一流期刊报道的一系列科研成果(总引用超过1600次,h-index 20),多篇论文入选ESI高被引论文和期刊封面;担任Nature Catalysis, Nature Communication等期刊特邀审稿人。出版英文专著一部,获Springer优秀论文奖、港中深青年科研奖;入选深圳市优青,广东省杰青人才。

学术著作

01. Zhou, Y.; Ni, J.; Lyu, Z.; Li, Y.; Wang, T.; Cheng, G.-J.*, Mechanism and Reaction Channels of Iron-catalyzed Primary Amination of Alkenes by Hydroxylamine Reagents. ACS Catal. 2023, doi.org/10.1021/acscatal.2c06046.
02. Zhou, H.; Zhou, Y.; Bae, H.; Leutzsch, M.; Li, Y.; De, C.; Cheng, G.-J.* (co-corresponding author) and List B.* Organocatalytic stereoselective cyanosilylation of small ketones. Nature, 2022, 605, 84–89.
03. Chen, G.; Zhou, R.; Zhang, X.; Xiao, X.; Kramer, S.; Cheng, G.-J.*; Lian, Z.*, Carbonylative Cross-Electrophile Coupling between Aryl Bromides and Aryl Triflates Enabled by Palladium and Rhodium Cooperative Catalysis and CO as Reductant. ACS Catal. 2022, 12, 14582-14591.
04. Zhou M, Wang T, Cheng, G.-J.*, Mechanistic insights into reductive deamination with hydrosilanes catalyzed by B(C6F5)3: A DFT study. Front Chem. 2022, 10: 1025135.
05. Zhao, R.; Zhang, B.-B., Liu, Z., Cheng, G.-J.*, and Wang Z.-X.* DFT Mechanistic Insights into Aldehyde Deformylations with Biomimetic Metal–Dioxygen Complexes: Distinct Mechanisms and Reaction Rules. JACS Au. 2022, 2, 3, 745–761.
06. Long, J. #; Xia, S. #; Wang, T.; Cheng, G.-J.*; Fang, X.*, Nickel-Catalyzed Regiodivergent Cyanation of Allylic Alcohols: Scope, Mechanism, and Application to the Synthesis of 1,n-Dinitriles. ACS Catal. 2021, 11, 13880-13890.
07. Sun, F.#; Wang, T.#; Cheng, G.-J.*; Fang, X.* Enantioselective Nickel-Catalyzed Hydrocyanative Desymmetrization of Norbornene Derivatives. ACS Catal. 2021, 11, 7578.
08. Sun, F.#; Yang, C.#; Ni, J., Cheng, G.-J.*; Fang, X.* Ligand-Controlled Regiodivergent Nickel-Catalyzed Hydrocyanation of Silyl-Substituted 1,3-Diynes. Org. Lett. 2021, 23, 4045.
09. Wang, T.; Zhou, Y.; Xu, Y.; Cheng, G.-J.,* Computational Exploration of Copper-Catalyzed Vinylogous Aerobic Oxidation of α,β- and β,γ-Unsaturated Compounds. Sci. Rep. 2021, 11, 1304.
10. Gao, J.#; Jiao, M.#; Ni, J.#; Yu, R.; Cheng, G.-J.*; Fang, X.* Diastereomeric Ligand-Controlled Regiodivergent Ni-Catalyzed Migratory Hydrocyanation of Internal Alkenes. Angew. Chem. Int. Ed. 2021, 60,1883. (*co-corresponding author)
11. Gao, J.#; Ni, J.#; Yu, R.; Cheng, G.-J.*; Fang, X.* Ni-Catalyzed Isomerization/Hydrocyanation Tandem Reactions: A Lewis Acid-Free Access to Linear Nitriles from Aliphatic Internal Olefins. Org. Lett. 2021, 23, 486.
12. Li, X.-T.; Lv, L.; Wang, T.; Gu, Q.-S. Xu, G.-X.; Li, Z.-L.; Ye, L.; Zhang, X.-H.; Cheng, G.-J.;* Liu, X.-Y.* Diastereo- and enantioselective catalytic radical oxysulfonylation of alkenes in β,γ-unsaturated ketoximes. Chem, 2020, 6, 1692-1706. (*co-corresponding author)
13. Xiong, B.#; Wang, T.#; Sun, H.; Li, Y.; Kramer, S.; Cheng, G.-J.*; and Lian Z.,* Nickel-Catalyzed Reductive Cross-Coupling Reactions for the Synthesis of gem-Difluorovinyl Arenes. ACS Catal. 2020. 10, 13616−13623. (co-corresponding author)
14. Sun, F.#; Ni, J.#; Cheng, G.-J.*; Fang, X.* Highly regio- and stereoselective Ni-catalyzed hydrocyanation of 1,3-Enynes. Chem. Eur. J. 2020, 26, 5956. (co-corresponding author)
15. Wang, L.#; Wang, T.#; Cheng, G.-J.; Li, X.; Wei, J.-J.; Guo, B.; Zheng, C.; Chen, G.; Ran, C.; Zheng, C., Direct C–H Arylation of Aldehydes by Merging Photocatalyzed Hydrogen Atom Transfer with Palladium Catalysis. ACS Catal. 2020, 7543-7551.
16. Deng, Y.; Zhao, C.; Zhou, Y.; Wang, H.; Li, X.; Cheng, G.-J.; Fu, J., Directing-group-based Strategy Enabling Intermolecular Heck-type Reaction of Cycloketone Oxime Esters and Unactivated Alkenes. Org. Lett. 2020, 2, 3524-3530.
17. Yang, C.; Li, P.; Ding, X.; Sui, C.; Rao, S.; Hsu, C.-H.; Leung, W.-P.; Cheng, G.-J.; Wang, P.; Zhu, B.; Mechanism for the Reactivation of the Peroxidase Activity of Human Cyclooxygenases: Investigation Using Phenol as a Reducing Cosubstrate. Sci. Rep. 2020, 10, 15187.
18. Yu, H.-J.; Zhao, W.; Zhou, Y.; Cheng, G.-J.; Sun, M.; Wang, L.; Yu, L.; Liang, S. H.; Ran, C., Salen-based bifunctional chemosensor for copper (II) ions: Inhibition of copper-induced amyloid-β aggregation. Analytica Chimica Acta, 2020, 8, 144.
19. Cheng, G.-J.*; Zhong, X.-M.; Wu, Y.-D.*; Zhang, X.*, Mechanistic understanding of catalysis by combining mass spectrometry and computation. Chem. Comm. 2019, 55, 12749. (First and co-corresponding author)
20. Chen, Z.; Tang, J.-H.; Chen, W.; Xu, Y.; Wang, H.; Zhang, Z.; Sepehrpour, H.; Cheng, G.-J.; Li, X.; Wang, P.; Sun, Y.; Stang, P. J. Temperature and Mechanical Force Responsive Self-Assembled Rhomboidal Metallacycle, Organometallics 2019, 38, 21, 4244.
21. Ma, X.; Mai, S.; Zhou, Y.; Cheng, G.-J.; Song, Q. Dual Role of Ethyl Bromodifluoroacetate in the Formation of Fluorine-containing Heteroaromatic Compounds. Chem. Commun. 2018, 54, 8960.
22. Cheng, G.-J.; Drosos, N.; Morandi, B.;Thiel, W. Computational Study of B(C6F5)3-Catalyzed Selective Deoxygenation of 1,2-Diols. ACS Catal. 2018, 8, 1697.
23. Escorcia, A. M..; Rijn, J. F. M.; Cheng, G.-J.; Thiel, W. Insight into the Promiscuity of Taxadiene Synthase: A Molecular Dynamic Study. J. Comp. Chem. 2018, 39,1215.
24. Drosos, N.; Cheng, G.-J.; Ozkal, E.; Cacherat, B.; Thiel, W.; Morandi, B. Catalytic Reductive Pinacol-Type Rearrangement of Unactivated 1,2-diols through a Concerted, Stereoinvertive Mechanism. Angew. Chem. Int. Ed. 2017, 56, 13377.
25. Rummelt, S.; Cheng, G.-J.; Gupta, P.; Thiel, W.; Fürstner, A. Hydroxyl-Directed Ruthenium Catalyzed Alkene/Alkyne Coupling: Increased Scope, Stereochemical Implications and Mechanistic Rationale. Angew. Chem. Int. Ed. 2017, 56, 3599.
26. Xie, Y.; Cheng, G.-J.; Lee, S.; Thiel, W.; List, B. Catalytic Asymmetric Vinylogous Prins Cyclization: A Highly Diastereo- and Enantioselective Entry to Tetrahydrofurans. J. Am. Chem. Soc. 2016, 138, 14538.
27. Jia, J.#; Cheng, G.-J.#; Wu, A.; Luan, S. Novel Imprinted Polyethyleneimine Nano-fluorescent Probes with Controllable Selectivity for Recognizing and Adsorbing Metal Ions RSC Advances 2017, 7, 36048. (#co-first author)
28. Zhong, X.-M. #; Cheng, G.-J. #; P.; Chen, P.; Zhang, X.; Yu, Wu, Y.-D. Mechanistic Study on Pd/Mono-N-protected Amino Acid Catalyzed Vinyl–Vinyl Coupling Reactions: Reactivity and E/Z Selectivity. Org. Lett. 2016, 18, 5240. (#co-first author)
29. Cheng, G.-J.; P.; Chen, P.; Sun, T.-Y.; Zhang, X.; Yu, J.-Q.; Wu, Y.-D. A Combined IM-MS/DFT Study on Pd(MPAA)-Catalyzed Enantioselective C−H Activation: Relay of Chirality through a Rigid Framework. Chem.–Eur. J. 2015, 21, 11180.
30. Cheng, G.-J.; Zhang, X.; Chung, L. W.; Xu, L.; Wu, Y.-D. Computational Organic Chemistry: Bridging Theory and Experiment by Mechanistic Understanding of Chemical Reactions. J. Am. Chem. Soc. 2015, 137, 1706.
31. Zhou, F.; Cheng, G.-J.#; Yang, W.; Long, Y.; Zhang, S.; Wu, Y.-D.; Zhang, X.; Cai, Q. Enantioselective Formation of Cyano-Bearing All-Carbon Quaternary Stereocenters: Desymmetrization by Copper-Catalyzed N-Arylation. Angew. Chem. Int. Ed. 2014, 53, 9555. (co-first author)
32. Cheng, G.-J.; Yang, Y.-F.; Liu, P.; Chen, P.; Sun, T.-Y.; Li, G.; Zhang, X.; Houk, K. N.; Yu, J.-Q.; Wu, Y.-D. Role of N-Acyl Amino Acid Ligands in Pd(II)-Catalyzed Remote C–H Activation of Tethered Arenes. J. Am. Chem. Soc. 2014, 136, 894.
33. Yang, Y.-F.; Cheng, G.-J.#; Liu, P.; Chen, P.; Zhang, X.; Yu, J.-Q.; Wu, Y.-D.; Houk, K. N. Palladium-Catalyzed Meta-Selective C–H Bond Activation with a Nitrile-Containing Template: Computational Study on Mechanism and Origins of Selectivity. J. Am. Chem. Soc. 2014, 136, 344. (#co-first author)
34. Cheng, G.-J.; Song, L.-J.; Yang, Y.-F.; Zhang, X.; Wiest, O.; Wu, Y.-D. Computational Studies on the Mechanism of the Copper-Catalyzed sp3-C-H Cross-Dehydrogenative Coupling Reaction. ChemPlusChem 2013, 78, 943 (Frontispiece paper).
35. Zhu, L.; Zhou, C.; Yang, W.; He, S.; Cheng, G.-J.; Zhang, X.; Lee, C.-S. Formal Syntheses of (±)-Platensimycin and (±)-Platencin via a Dual-Mode Lewis Acid Induced Cascade Cyclization Approach. J. Org. Chem. 2013, 78, 7912.
36. Zhao, K.; Cheng, G.-J.; Yang, H.; Shang, H.; Zhang, X.; Wu, Y.-D.; Tang, Y. Total Synthesis of Incarvilleatone and Incarviditone: Insight into Their Biosynthetic Pathways and Structure Determination. Org. Lett. 2012, 14, 4878.
37. Yang, Y.-F.; Cheng, G.-J.; Zhu, J.; Zhang, X.; Inoue, S.; Wu, Y.-D. Silicon-Containing Formal 4pi-Electron Four-Membered Ring Systems: Antiaromatic, Aromatic, or Not? Chem. Eur. J. 2012, 18, 7516.
38. BOOK Cheng, G.-J. “Mechanistic Studies on Transition Metal-Catalyzed C-H Activation Reactions Using Combined Mass Spectrometry and Theoretical Methods” Springer Theses, 2017, ISBN:978-981-10-4520-2.