王丽娟

客座副教授

教育背景

博士  中山大学

研究领域
帕金森病、认知障碍、脑血管病
电子邮件
wljgd68@163.com
个人简介

王丽娟教授1985年本科毕业于上海医科大学,并于1996年获中山医科大学(现中山大学)神经病学博士学位。1999年至今担任广东省人民医院神经科主任,并兼任广东省神经科学研究所所长。2006年访学加拿大不列颠哥伦比亚大学神经科学部。现任中国医师协会神经内科医师分会副会长、中华医学会神经病学分会帕金森及运动障碍学组副组长、中国医师协会神经内科医师分会委员会帕金森病及运动障碍学组副组长、中国卒中学会移动医疗分会副主任委员、粤港澳大湾区神经科医师联盟主任、广东省医师协会神经内科医师分会主任委员。研究内容主要围绕帕金森病,脑血管病及认知障碍(包括阿尔茨海默病)的临床、神经心理、多模态影像、发病分子机制及血管机制等。作为项目负责人主持国家重点研发计划1项、国家自然科学基金面上项目4项、广东省自然科学基金、广东省重点科技攻关项目、广州市重点科技项目等科研项目共20项。牵头执笔、参与中国血管性帕金森综合征、帕金森病及其他运动障碍疾病诊疗共识、指南等多项。在《Parkinsonism & Related Disorders》《Stroke》《Neurobiology of Aging》等SCI收录杂志及国内核心期刊发表文章百余篇。获国家专利5项,申请发明专利3项。获国家科技进步二等奖、卫生部医药卫生科技进步一等奖、省部级科技进步一、二等奖等7项。

学术著作

部分学术著作:
1. Wang, W.Y., Mei, M.J., Gao, Y.Y., Huang, B., Qiu, Y.H., Zhang, Y.H., Wang, L.M., Zhao, J.H., Huang, Z.H., Wang, L.J., and Nie, K. (2020). Changes of brain structural network connection in Parkinson's disease patients with mild cognitive dysfunction: a study based on diffusion tensor imaging. J. Neurol. 267:933-943. PMID:31792673
2. Ren, T.Z., Gao, Y.Y., Qiu, Y.H., Jiang, S.L., Zhang, Q.X., Zhang, J.H., Wang, L.M., Zhang, Y.H., Wang, L.J., and Nie, K. (2020). Gut Microbiota Altered in Mild Cognitive Impairment Compared With Normal Cognition in Sporadic Parkinson's Disease. Front. Neurol. 11:137. PMID:32161568
3. Gao, Y.Y., Tang, H.M., Nie, K., Zhu, R.M., Gao, L., Feng, S.J., Wang, L.M., Zhao, J.H., Huang, Z.H., Zhang, Y.H., and Wang, L.J. (2019). Hippocampal damage and white matter lesions contribute to cognitive impairment in MPTP-lesioned mice with chronic cerebral hypoperfusion. Behav. Brain. Res. 368:111885. PMID: 30959125
4. Li, S.Y., Nie, K., Zhang, Q.X., Guo, M.L., Qiu, Y.H., Li, Y., Gao, Y.Y., and Wang, L.J. (2019). Macrophage Migration Inhibitory Factor Mediates Neuroprotective Effects by Regulating Inflammation, Apoptosis and Autophagy in Parkinson's Disease. Neuroscience. 416:50-62. PMID: 31170483
5. Zhang, S., Zhao, J.H., Zhang, Y.H., Zhang, Y., Cai, F., Wang, L.J., and Song, W.H. (2019). Upregulation of MIF as a defense mechanism and a biomarker of Alzheimer's disease. Alzheimers. Res. Ther. 11:54. PMID: 31174614
6. Gao, Y.Y., Nie, K., Mei, M.J., Guo, M.L., Huang, Z.H., Wang, L.M., Zhao, J.H., Huang, B., Zhang, Y.H., and Wang, L.J. (2018). Changes in Cortical Thickness in Patients With Early Parkinson's Disease at Different Hoehn and Yahr Stages. Front. Hum. Neurosci. 12:469. PMID: 30542273
7. Wang, L., Nie, K., Zhao, X., Feng, S.J., Xie, S.F., He, X.T., Ma, G.X., Wang, L.M., Huang, Z.H., Huang, B., Zhang, Y.H., and Wang, L.J. (2018). Characteristics of gray matter morphological change in Parkinson's disease patients with semantic abstract reasoning deficits. Neurosci. Lett. 673:85-91. PMID: 29275185
8. Zhang, G.H., Zhang, C.G., Zhang, Y.H., Wang, Y.K., Nie, K., Zhang, B., Xie, H.Q., Lu, J.C., and Wang, L.J. (2017). The effects of striatal silent lacunar infarction on the substantia nigra and movement disorders in Parkinson's disease: A follow-up study. Parkinsonism. Relat. Disord. 43:33-37. PMID: 28688982
9. Huang, J., Zhuo, W.Y., Zhang, Y.H., Sun, H.C., Chen, H., Zhu, P.P., Pan, X.B., Yang, J.H., and Wang, L.J. (2017). Cognitive Function Characteristics of Parkinson's Disease with Sleep Disorders. Parkinsons. Dis. 2017: 4267353. PMID: 28484661
10. Tang, H.M., Gao, Y.Y., Zhang, Q.X., Nie, K., Zhu, R.M., Gao, L., Feng, S.J., Wang, L.M., Zhao, J.H., Huang, Z.H., Zhang, Y.H., and Wang, L.J. (2017). Chronic cerebral hypoperfusion independently exacerbates cognitive impairment within the pathopoiesis of Parkinson's disease via microvascular pathologys. Behav. Brain. Res. 333: 286-294. PMID: 28578987
11. Gao, Y.Y., Nie, K., Huang, B., Mei, M.J., Guo, M.L., Xie, S.F., Huang, Z.H., Wang, L.M., Zhao, J.H., Zhang, Y.H., and Wang, L.J. (2017). Changes of brain structure in Parkinson's disease patients with mild cognitive impairment analyzed via VBM technology. Neurosci. Lett. 658:121-132. PMID: 28823894
12. Nie. K., Feng, S.J., Tang, H.M., Ma, G.X., Gan, R., Zhao, X., Zhao, J.H., Wang, L.M., Huang, Z.H., Huang, J., Gao, L., Zhang, Y.W., Zhu, R.M., Duan, Z.P., Zhang, Y.H., and Wang, L.J. (2015). RIT2 polymorphism is associated with Parkinson’s disease in a Han Chinese population. Neurobiol. Aging. 36: 1603.e15-17. PMID: 25457028
13. Feng, S.J., Nie, K., Gan, R., Huang, J., Zhang, Y.W., Wang, L.M., Zhao, J.H., Tang, H.M., Gao, L., Zhu, R.M., Duan, Z.P., Zhang, Y.H., and Wang, L.J. (2014). Triggering receptor expressed on myeloid cells 2 variants are rare in Parkinson's disease in a Han Chinese cohort. Neurobiol. Aging. 35: 1780.e11-12. PMID: 24602511
14. Nie, K., Zhang, Y.H., Huang, B., Wang, L.M., Zhao, J.H., Huang, Z.H., Gan, R., and Wang, L.J. (2013). Marked N-acetylaspartate and choline metabolite changes in Parkinson’s disease patients with mild cognitive impairment. Parkinsonism. Relat. Disord. 19: 329-334. PMID: 23238068
15. Wang, L.J., Zis, O., Ma, G.X., Shan, Z.X., Zhang, X., Wang, S., Dai, C.B., Zhao, J.H., Lin, Q.X., Lin, S.G., and Song, W.H. (2009). Upregulation of macrophage migration inhibitory factor gene expression in stroke. Stroke. 40: 973-976. PMID: 19131653