博士 （香港中文大学）

学士 （武汉大学）

雷湧博士于武汉大学获得本科学位，并于2013年获香港中文大学博士学位。博士期间利用基因组编辑技术（ZFNs，TALENs，CRISPR）从事转基因动物模型构建和动物早期胚胎发育研究。作为最早实现动物体内特异基因敲除的研究人员之一，其成果及相关论文成功入选Science 2012年度十大科学突破。2014年赴美国贝勒医学院从事博士后研究，师从著名血液病专家Margaret A. Goodell教授，专注于特异性DNA甲基化编辑和异常的DNA甲基化在白血病早期发病中作用。成功开发出DNA甲基化编辑技术，并实现全球首例小鼠受精卵甲基化编辑。

2020年6月加入香港中文大学（深圳），从事研究衰老过程中表观基因组保真机制的退化对DNA甲基化谱的影响，以及利用DNA甲基化编辑探究表观修饰在跨代遗传中的丢失和重建。在国际高水平期刊Nature Genetics, Genome Biology, Nature Communications, Nucleic Acids Research, PNAS等发表论文多篇。

Selected Publications:

1. Yiliyaer N, Li X, Guo T, Zhou H, Gong L, Yuan L, Fu Y, Qiao Y, Lui YL, Chen N, Lin P, Cheung HH, Ko H, Meng L, Chen X, Lei Y, Kwan KM, Wang H, Gu S*. Pathogenicity of Mediator Complex Subunit 27 (MED27) in a Neurodevelopmental Disorder with Cerebellar Atrophy. Adv Sci. 2025 

2. Yuan L, Xiong Y, Zhang Y, Gu S, Lei Y*. Epigenome editing based treatment: Progresses and challenges. Mol Ther. 2025

3. Li X, Yiliyaer N, Guo T, Zhao H, Lei Y*, Gu S*. The indispensable role of Mediator complex subunit 27 during neurodevelopment. Cell BioSci. 2025 

4. Wang JX, Zhang L, Zhang PW, Yuan LW, Jiang J, Cheng XH, Zhu W, Lei Y*, Tian FQ. Boanmycin overcomes bortezomib resistance by inducing DNA damage and endoplasmic reticulum functional impairment in multiple myeloma. Biol Direct. 2025 

5. Ho NJ, Chen X, Lei Y*, Gu S*. Decoding hereditary spastic paraplegia pathogenicity through transcriptomic profiling. Zool Res. 2023 

6. Lei Y, Huang YH, Goodell MA. DNA methylation and de-methylation using hybrid site-targeting proteins. Genome Biol. 2018

7. Huang YH, Su JZ, Lei Y, Brunetti L, Gundry MC, Zhang XT, Jeong M, Li W, Goodell MA. DNA epigenome editing using CRISPR-Cas SunTag-directed DNMT3A. Genome Biol. 2017

8. Lei Y, Zhang XT, Su JZ, Jeong M, Gundry MC, Huang YH, Zhou YB, Li W, Goodell MA. Targeted DNA methylation in vivo using an engineered dCas9-MQ1 fusion protein. Nat Commun. 2017

9. Hu JB, Lei Y, Wong WK, Liu SQ, Lee KC, He XJ, You WX, Zhou R, Guo JT, Chen XF, Peng XL, Sun H, Huang H, Zhao H, Feng B. Direct activation of human and mouse Oct4 genes using engineered TALE and Cas9 transcription factors. Nucleic Acids Research, 2014 

10. Li G, Feng J, Lei Y, Wang J, Wang H, Shang LK, Liu DT, Zhao H, Zhu Y, Wang YQ. Mutagenesis at specific genomic loci of amphioxus Branchiostoma belcheri using TALEN method. J Genet Genomics. 2014

11. Lei Y, Guo XG, Deng Y, Chen YL, Zhao H. Generation of gene disruptions by transcription activator-like effector nucleases (TALENs) in Xenopus tropicalis embryos. Cell Biosci. 2013

12. Lei Y, Guo XG, Liu Y, Cao Y, Deng Y, Chen XF, Cheng HK, Dawid IB, Chen YL, Zhao H. Efficient targeted gene disruption in Xenopus embryos using engineered transcription activator-like effector nucleases (TALENs). Proc. Natl. Acad. Sci. U.S.A. 2012

    (Editorial highlight; Cited by Science Ten Breakthroughs of 2012; Interviewed by BioTechniques.)