黄宪达

副院长(学生事务)、瓦谢尔计算生物研究院执行院长、生物信息学硕士项目主任
科睿唯安全球高被引科学家

校长讲座教授, 教授

教育背景

本科(台湾中央大学)

博士(台湾中央大学信息工程学系)

学术领域
生物信息学
研究领域
生物信息、基因体学、智能生医科技(药物设计、基因检测、精准医疗)、生物数据库
电子邮件
huanghsienda@cuhk.edu.cn
个人简介

黄宪达教授目前担任香港中文大学(深圳)校长讲座教授、医学院副院长(学生事务)与瓦谢尔计算生物研究院执行院长。于台湾中央大学资讯工程学系获得博士学位(2003),曾任职于台湾交通大学生物科技学系主任及生物科技学院副院长;台湾生物资讯学会理事长。
黄教授主要通过生物数据库设计与算法开发,进行多组学数据探索疾病靶标与药物靶点等领域的研究,致力于中草药分子层次《本草纲目》平台的建设,为实现辅助中草药精准化医疗平台的应用创造了条件,并将其应用于药物设计关键毒理与药理评估,助力新药开发。发表>200篇学术论文,包括Science, Nucleic Acids Research,Nature Immunology,Circulation,Hepatology,Journal of Clinical Investigation与Molecular Cell等期刊。H-index 为68,总引用次数超过24396次, 近5年>13377次 (Google Scholar)。在Web of Science 中有15篇高被引论文(Highly Cited Papers - 10年间被引用次数前 1% 的文章)
黄教授连续五年入选科睿唯安(Clarivate Analytics)“高被引科学家”名单(2019年-2023年)和美国斯坦福大学发布全球前2%顶尖科学家榜单(World’s Top 2% Scientists)(2019年-2023年)。其开发的miRTarBase于2020年荣获“中国生物信息学十大进展”的荣誉,相关论文被引用次数达3000次以上。荣获爱思唯尔(Elsevier)2021、2022“中国高被引学者”。

Google Scholar (https://scholar.google.com/citations?hl=en&user=dj4nF7IAAAAJ)

PubMed (https://pubmed.ncbi.nlm.nih.gov/?term=huang+hsien-da%5Bau%5D+&sort=date)

学术著作

1.      miRTarBase update 2018: a resource for experimentally validated microRNA-target interactions. (2018) Nucleic Acids Res., Vol. 46, D1, pp. D296-D302. (SCI, highly-cited paper)

2.      Plants send small RNAs in extracellular vesicles to fungal pathogen to silence virulence genes. (2018) Science, Vol. 360, No. 6393, pp. 1126-1129.

3.      MicroRNA-224 down-regulates Glycine N-methyltransferase gene expression in Hepatocellular Carcinoma. (2018) Scientific Report, Vol.8, No.1, pp.12284.

4.      Large-Scale Functional Analysis of CRP-Mediated Feed-Forward Loops. (2018) Int. J. Mol. Sci., Vol. 19, No.8, pp. E2335.

5.      Ouroboros resembling competitive endogenous loop (ORCEL) in circular RNAs revealed through transcriptome sequencing dataset analysis. (2018) BMC Genomics, Vol.19 (Suppl. 2), pp.171.

6.      MicroRNA-92a Mediates Endothelial Dysfunction in CKD. (2017) J. Am Soc. Nephrology, Vol. 28, No. 11, pp. 3251-3261.

7.      α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming. (2017) Nature Immunology, Vol. 18, No. 9, pp. 985-994.

8.      Bidirectional cross-kingdom RNAi and fungal uptake of external RNAs confer plant protection. (2016) Nature Plants, Vol. 2, pp. 16151. (SCI, highly-cited paper)

9.      Krüppel-Like Factor 4 Regulation of Cholesterol-25-Hydroxylase and Liver X Receptor Mitigates Atherosclerosis Susceptibility. (2017) Circulation, Vol. 136, No. 14, pp. 1315-1330.

10.   dbPTM 2016: 10-year anniversary of a resource for post-translational modification of proteins. (2016) Nucleic Acids Research, Vol. 44, D1, pp. D435-46.

11.   miRTarBase 2016: updates to the experimentally validated miRNA-target interactions database. (2016) Nucleic Acids Research, Vol. 44, D1, pp. D239-47. (SCI, highly-cited paper)

12.   PlantPAN 2.0: an update of plant promoter analysis navigator for reconstructing transcriptional regulatory networks in plants. (2016) Nucleic Acids Research, Vol. 44, D1, pp. D1154-60.

13.   CircNet: a database of circular RNAs derived from transcriptome sequencing data. (2016) Nucleic Acids Research, Vol. 44, D1, pp. D209-15. (SCI, highly-cited paper)

14.   MethHC: a database of DNA methylation and gene expression in human cancer. (2015) Nucleic Acids Research, Vol. 43 (Database issue), pp. D856-61.

15.   Oxidative stress activates endothelial innate immunity via sterol regulatory element binding protein 2 (SREBP2) transactivation of microRNA-92a. (2015) Circulation, Vol. 131, No. 9, pp. 805-14.

16.   The effects of actin cytoskeleton perturbation on keratin intermediate filament formation in mesenchymal stem/stromal cells. (2014) Biomaterials, Vol. 35, No. 13, pp. 3934-44.

17.   miRTarBase update 2014: an information resource for experimentally validated miRNA-target interactions. (2014) Nucleic Acids Research, Vol. 42, pp. D78-85. (SCI, highly-cited paper)

18.   COL11A1 Promotes Tumor Progression, and Predicts Poor Clinical Outcome in Ovarian Cancer. (2013) Oncogene, Vol. 33, No. 26, pp. 3432-40.

19.   Transcribed pseudogene ψPPM1K generates endogenous siRNA to suppress oncogenic cell growth in hepatocellular carcinoma. (2013) Nucleic Acids Research, Vol. 41, No. 6, pp. 3734-47.

20.   Sterol Regulatory Element Binding Protein 2 Activation of NLRP3 Inflammasome in Endothelium Mediates Hemodynamic-Induced Atherosclerosis Susceptibility. (2013) Circulation, Vol. 128, No. 6, pp. 632-42.

21.   Hypoxia-responsive miRNAs target argonaute 1 to promote angiogenesis. (2013) Journal of Clinical Investigation, Vol. 123, No. 3, pp. 1057-67.

22.   Fungal small RNAs as novel effectors to suppress plant immunity by hijacking the host RNAi machinery. Science, Vol. 342, No. 6154, pp. 118-123. (SCI, highly-cited paper)

23.   MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis. (2012) Journal of Clinical Investigation, Vol. 122, No. 8, pp. 2884-97. (SCI, highly-cited paper)

24.   Let-7b is a novel regulator of hepatitis C virus replication. (2012) Cellular and Molecular Life Sciences, Vol. 69, No. 15, pp. 2621-33.

25.   Clusters of nucleotide substitutions and insertion/deletion mutations are associated with repeat sequences. (2011) PLoS Biology, Vol. 9, No. 6, e1000622.

26.   RegPhos: a system to explore the protein kinase-substrate phosphorylation network in humans. (2011) Nucleic Acids Research, Vol.39, pp. D777-87.

27.   miRTarBase: a database curates experimentally validated microRNA-target interactions. (2011) Nucleic Acids Research, Vol.39, pp. D163-9. (SCI, highly-cited paper)

28.   miR-103/107 promote metastasis of colorectal cancer by targeting the metastasis suppressors DAPK and KLF4. (2012) Cancer Research, Vol. 72, No. 14, pp. 3631-41. (SCI, highly-cited paper)

29.   Identifying transcriptional start sites of human microRNAs based on high-throughput sequencing data. (2011) Nucleic Acids Research, Vol. 39, No. 21, pp.9345-9356.

30.   Arabidopsis Argonaute 2 Regulates Innate Immunity via miRNA393*-Mediated Silencing of a Golgi-Localized SNARE Gene, MEMB12. (2011) Molecular Cell, Vo. 42, No. 3, pp. 356-366.

31.   Flow-regulation of Krüppel-like Factor 2 Is Mediated by MicroRNA-92a (2011) Circulation, Vol. 124, No. 5, pp. 633-41.

32.   MicroRNA-122, a tumor suppressor microRNA that regulates intrahepatic metastasis of hepatocellular carcinoma. (2009) Hepatology, Vol. 49, No. 5, pp. 1571-82. (SCI, highly-cited paper)