CIECHANOVER, Aaron
访问教授
博士 以色列理工学院
亚伦·切哈诺沃(Aaron Ciechanover)博士,以色列生物学家、化学家,也是第一位获得科学类诺贝尔奖的以色列人, 以色列人文和自然科学院院士、美国国家科学院外籍院士、中国科学院外籍院士,中国南京大学名誉教授,南京大学化学与生物医药科学研究所所长。他于1947年生于以色列海法,1981年在以色列理工学院获医学博士学位,1984年在麻省理工学院从事博士后研究,1980年在以色列理工学院任教,1992被聘为教授。2004年他与以色列科学家阿夫拉姆·赫什科(Avram Hershko)、美国科学家欧文·罗斯(Irwin Rose)发现了泛素调节的蛋白质降解(一种蛋白质降解的重要机理),共同获得诺贝尔化学奖。2013年12月19日当选中科院生物化学部外籍院士。
部分学术著作:
Ciechanover, A., Hod, Y. and Hershko, A. (1978). A Heat-stable Polypeptide Component of an ATP-dependent Proteolytic System from Reticulocytes. Biochem. Biophys. Res. Commun. 81, 1100–1105.
Ciechanover, A., Heller, H., Elias, S., Haas, A.L. and Hershko, A. (1980). ATP-dependent Conjugation of Reticulocyte Proteins with the Polypeptide Required for Protein Degradation. Proc. Natl. Acad. Sci. USA 77, 1365–1368.
Hershko, A. and Ciechanover, A. (1982). Mechanisms of intracellular protein breakdown. Annu. Rev. Biochem. 51, 335–364.
所获荣誉
In 2000, Ciechanover received the Albert Lasker Award for Basic Medical Research.
In 2003, he was awarded the Israel Prize, for biology.
In 2004, he was awarded Nobel Prize in Chemistry for his discovery with Avram Hershko and Irwin Rose, of ubiquitin-mediated protein degradation.The ubiquitin-proteasome pathway has a critical role in maintaining the homeostasis of cells and is believed to be involved in the development and progression of diseases such as: cancer, muscular and neurological diseases, immune and inflammatory responses.
In 2006, he was awarded the Sir Hans Krebs Medal
In 2009, he was conferred an Honorary Doctorate in Science by the University of Cambodia