孙昊

教授

教育背景

博士（南京大学）

硕士（美国阿克伦大学）

学士（南京大学）

研究领域
生物信息学；基因组学；非侵入性产前诊断和癌症早期诊断；非编码RNA的发现及其在肌肉干细胞中的转录调控机理研究；高通量测序数据分析；基于测序数据的分子疾病诊断方法研发、相关生物信息学算法、软件和数据库的开发
电子邮件
sunhao100@cuhk.edu.cn
个人简介

孙昊教授于1998年在南京大学取得博士学位，2002年在美国阿克伦大学获得计算机科学硕士学位。2001-2008年在俄亥俄州立大学分子病毒学、免疫学和医学遗传学系担任研究科学家和兼职助理教授；2008-2009年，在费城Wistar研究所担任生物信息学核心实验室联合主任；2009-2024年，他加入香港中文大学，先后担任李嘉诚健康科学研究所化学病理学助理教授、副教授、教授和生物医学计算中心主任。他的研究重点是发现和功能注释非编码RNA在肌肉干细胞中的转录调控机理，开发用于无创基因诊断的生物信息学工具，以及发现新的生物标志物用于癌症的诊断和个性化精准医疗。

孙教授曾分别担任Journal of Clinical Biochemistry和PLoS ONE的副主编和学术编辑。多年来，孙教授获得过香港特别行政区和中国内地政府支持的多项研究基金，如香港大学教育资助委员会优配基金项目（RGC/GRF）、卓越学科领域计划（AoE）、主题研究计划（TRS），以及香港和中国内地的国家自然科学基金委员会-研究资助局联合资助项目（NSFC-RGC）。他发表了130多篇同行评审出版物，引用次数超过12,000次，大部分文章都发表在著名期刊上如Cell、Cancer Cell、Molecular Cell、Science of Translational Medicine、Nature Medicine、Nature Communications、Genome Research和Nucleic Acids Research等。孙教授实验室现面向感兴趣的博士后、博士生、硕士生以及本科生交换生开放申请。

学术著作

  1. Lin Y, Zhang Y, Sun H, Jiang H, Zhao X, Teng X, Lin J, Shu B, Sun H, Liao Y, Zhou J. NanoDeep: a deep learning framework for nanopore adaptive sampling on microbial sequencing. Brief Bioinform. 2023;25(1):bbad499. doi: 10.1093/bib/bbad499.
  2. Zhang S, Yang F, Huang Y, He L, Li Y, Wan YCE, Ding Y, Chan KM, Xie T, Sun H, Wang H. ATF3 induction prevents precocious activation of skeletal muscle stem cell by regulating H2B expression. Nat Commun. 2023;14(1):4978. doi: 10.1038/s41467-023-40465-w.
  3. Zhao Y, Ding Y, He L, Zhou Q, Chen X, Li Y, Alfonsi MV, Wu Z, Sun H, Wang H. Multiscale 3D genome reorganization during skeletal muscle stem cell lineage progression and aging. Sci Adv. 2023 Feb 17;9(7):eabo1360. doi: 10.1126/sciadv.abo1360.
  4. Qiao Y, Sun Q, Chen X, He L, Wang D, Su R, Xue Y, Sun H, Wang H. Nuclear m6A reader YTHDC1 promotes muscle stem cell activation/proliferation by regulating mRNA splicing and nuclear export. Elife. 2023;12:e82703. doi: 10.7554/eLife.82703.
  5. So KKH, Huang Y, Zhang S, Qiao Y, He L, Li Y, Chen X, Sham MH, Sun H, Wang H. seRNA PAM controls skeletal muscle satellite cell proliferation and aging through trans regulation of Timp2 expression synergistically with Ddx5. Aging Cell. 2022;21(8):e13673. doi: 10.1111/acel.13673.
  6. Liang C, Ke Q, Liu Z, Ren J, Zhang W, Hu J, Wang Z, Chen H, Xia K, Lai X, Wang Q, Yang K, Li W, Wu Z, Wang C, Yan H, Jiang X, Ji Z, Ma M, Long X, Wang S, Wang H, Sun H, Belmonte JCI, Qu J, Xiang AP, Liu GH. BMAL1 moonlighting as a gatekeeper for LINE1 repression and cellular senescence in primates. Nucleic Acids Res. 2022;50(6):3323-3347. doi: 10.1093/nar/gkac146.
  7. Chen X, Yuan J, Xue G, Campanario S, Wang D, Wang W, Mou X, Liew SW, Umar MI, Isern J, Zhao Y, He L, Li Y, Mann CJ, Yu X, Wang L, Perdiguero E, Chen W, Xue Y, Nagamine Y, Kwok CK, Sun H, Muñoz-Cánoves P, Wang H. Translational control by DHX36 binding to 5'UTR G-quadruplex is essential for muscle stem-cell regenerative functions. Nat Commun. 2021;12(1):5043. doi: 10.1038/s41467-021-25170-w.
  8. Huang Y, Qiao Y, Zhao Y, Li Y, Yuan J, Zhou J, Sun H, Wang H. Large scale RNA-binding proteins/LncRNAs interaction analysis to uncover lncRNA nuclear localization mechanisms. Brief Bioinform. 2021;22(6):bbab195. doi: 10.1093/bib/bbab195.
  9. Zheng Q, Li G, Wang S, Zhou Y, Liu K, Gao Y, Zhou Y, Zheng L, Zhu L, Deng Q, Wu M, Di A, Zhang L, Zhao Y, Zhang H, Sun H, Dong C, Xu H, Wang X. Trisomy 21-induced dysregulation of microglial homeostasis in Alzheimer's brains is mediated by USP25. Sci Adv. 2021;7(1):eabe1340. doi: 10.1126/sciadv.abe1340.
  10. He L, Ding Y, Zhao Y, So KK, Peng XL, Li Y, Yuan J, He Z, Chen X, Sun H, Wang H. CRISPR/Cas9/AAV9-mediated in vivo editing identifies MYC regulation of 3D genome in skeletal muscle stem cell. Stem Cell Reports. 2021;16(10):2442-2458. doi: 10.1016/j.stemcr.2021.08.011.
  11. Sun X, Ren Z, Cun Y, Zhao C, Huang X, Zhou J, Hu R, Su X, Ji L, Li P, Mak KLK, Gao F, Yang Y, Xu H, Ding J, Cao N, Li S, Zhang W, Lan P, Sun H, Wang J, Yuan P. Hippo-YAP signaling controls lineage differentiation of mouse embryonic stem cells through modulating the formation of super-enhancers. Nucleic Acids Res. 2020;48(13):7182-7196. doi: 10.1093/nar/gkaa482.
  12. Li Y, Yuan J, Chen F, Zhang S, Zhao Y, Chen X, Lu L, Zhou L, Chu CY, Sun H, Wang H. Long noncoding RNA SAM promotes myoblast proliferation through stabilizing Sugt1 and facilitating kinetochore assembly. Nat Commun. 2020;11(1):2725. doi: 10.1038/s41467-020-16553-6.
  13. Sun K, Jiang P, Cheng SH, Cheng THT, Wong J, Wong VWS, Ng SSM, Ma BBY, Leung TY, Chan SL, Mok TSK, Lai PBS, Chan HLY, Sun H, Chan KCA, Chiu RWK, Lo YMD. Orientation-aware plasma cell-free DNA fragmentation analysis in open chromatin regions informs tissue of origin. Genome Res. 2019;29(3):418-427. doi: 10.1101/gr.242719.118.
  14. Bao X, Guo X, Yin M, Tariq M, Lai Y, Kanwal S, Zhou J, Li N, Lv Y, Pulido-Quetglas C, Wang X, Ji L, Khan MJ, Zhu X, Luo Z, Shao C, Lim DH, Liu X, Li N, Wang W, He M, Liu YL, Ward C, Wang T, Zhang G, Wang D, Yang J, Chen Y, Zhang C, Jauch R, Yang YG, Wang Y, Qin B, Anko ML, Hutchins AP, Sun H, Wang H, Fu XD, Zhang B, Esteban MA. Capturing the interactome of newly transcribed RNA. Nat Methods. 2018;15(3):213-220. doi: 10.1038/nmeth.4595.
  15. Zhao Y, Sun H, Wang H. Long noncoding RNAs in DNA methylation: new players stepping into the old game. Cell Biosci. 2016;6:45. doi: 10.1186/s13578-016-0109-3.
  16. Jiang P, Sun K, Lun FM, Guo AM, Wang H, Chan KC, Chiu RW, Lo YM, Sun H. Methy-Pipe: an integrated bioinformatics pipeline for whole genome bisulfite sequencing data analysis. PLoS One. 2014;9(6):e100360. doi: 10.1371/journal.pone.0100360.
  17. Yu SC, Chan KC, Zheng YW, Jiang P, Liao GJ, Sun H, Akolekar R, Leung TY, Go AT, van Vugt JM, Minekawa R, Oudejans CB, Nicolaides KH, Chiu RW, Lo YM. Size-based molecular diagnostics using plasma DNA for noninvasive prenatal testing. Proc Natl Acad Sci U S A. 2014;111(23):8583-8. doi: 10.1073/pnas.1406103111.
  18. Chan KC, Jiang P, Zheng YW, Liao GJ, Sun H, Wong J, Siu SS, Chan WC, Chan SL, Chan AT, Lai PB, Chiu RW, Lo YM. Cancer genome scanning in plasma: detection of tumor-associated copy number aberrations, single-nucleotide variants, and tumoral heterogeneity by massively parallel sequencing. Clin Chem. 2013;59(1):211-24. doi: 10.1373/clinchem.2012.196014.
  19. Chiu RW, Akolekar R, Zheng YW, Leung TY, Sun H, Chan KC, Lun FM, Go AT, Lau ET, To WW, Leung WC, Tang RY, Au-Yeung SK, Lam H, Kung YY, Zhang X, van Vugt JM, Minekawa R, Tang MH, Wang J, Oudejans CB, Lau TK, Nicolaides KH, Lo YM. Non-invasive prenatal assessment of trisomy 21 by multiplexed maternal plasma DNA sequencing: large scale validity study. BMJ. 2011;342:c7401. doi: 10.1136/bmj.c7401. PMID: 21224326; PMCID: PMC3019239.
  20. Lo YM, Chan KC, Sun H, Chen EZ, Jiang P, Lun FM, Zheng YW, Leung TY, Lau TK, Cantor CR, Chiu RW. Maternal plasma DNA sequencing reveals the genome-wide genetic and mutational profile of the fetus. Sci Transl Med. 2010 Dec 8;2(61):61ra91. doi: 10.1126/scitranslmed.3001720.