YIN, Yuxin

Presidential Chair Professor, Professor

Education Background

Ph.D. in Biology and Genetics (University of North Carolina at Chapel Hill)

M.D. in Medicine (Peking Union Medical College)

Research Field
Cancer Biology
Email
yinyuxin@cuhk.edu.cn
Biography

Dr. Yuxin Yin is the Professor of Cancer Biology, Presidential Chair Professor, Chinese University of Hong Kong (Shenzhen) School of Medicine. Dr. Yin received his M.D. from the Peking Union Medical College and his Ph.D. from the University of North Carolina at Chapel Hill, USA. He conducted his postdoctoral training in Princeton University. In 1999, he was appointed as a tenure-track assistant professor in the Department of Radiation Oncology in the College of Physicians and Surgeons, Columbia University and was promoted to an associated professor with tenure in 2007. Dr. Yin’s research field is cancer biology with main focus on tumor suppressors p53 and PTEN in cell cycle regulation, apoptosis and genomic stability. In 1992, he reported a fundamental role for p53 in controlling the G1 checkpoint and maintaining genomic stability (Cell, 1992). In 1998, he found that p53 is required for the cellular apoptotic response to oxidative stress (Nature, 1998). In 2003, his team at Columbia demonstrated that PAC1 phosphatase is a direct transcriptional target of p53 in signaling apoptosis and tumor suppression, establishing a link between p53 and the MAP kinase cascade (Nature, 2003). In 2007, his group reported that PTEN plays a fundamental role in the maintenance of chromosome stability and that PTEN does so through physical interaction with centromeres (Cell, 2007). In 2015, his group revealed a new mechanism for DNA replication (Cell Research, 2015) and demonstrated that PTEN could controls the DNA replication process in response to replicative stress (Cell Reports, 2015). His group revealed a novel mechanism of alternative translation of protein and discovered some new members of the PTEN protein family named PTENα (Cell Metabolism, 2014), PTEN β (Nature Communications, 2017) and PTENε (EMBO, 2021). They also found that PTENα protein plays an important role in regulating the chemotaxis of neutrophils (Blood, 2019). In addition, they found PTEN is methylated by PRMT6 at arginine residue in modulation of pre-mRNA splicing (PNAS, 2019). These studies provide new insights into the mechanisms by which the PTEN family maintains genomic stability, suppresses tumorigenesis and development. In the field of immunity, they found that PAC1/DUSP2 phosphatase dephosphorylates STAT3 and modulates TH17 development in inflammatory disease (Nature Immunology, 2015). They also reported for the first time that PAC1, as a negative regulator of the immune system, specifically inhibits the defense function of T lymphocytes and promotes tumor immune escape (Nature Immunology, 2020). In addition, they revealed that PTENα functions as an immune suppressor and promotes immune resistance in PTEN-mutant cancer (Nature Communications, 2021). In translational medicine, his group isdeveloping AI aided metabolomic methods to detect early stage of cancers (Science Advances, 2021; Science Translational Medicine, 2021). His team has also developed several new small molecule chemical compounds to inhibit tumor growth, or activate the immune system to kill tumor cells, and promote tumor immunotherapy.

Academic Publications
  1. Yin, Y., Tainsky, M. A. Bischoff, F. A., Strong, L.C. and Wahl, G. M. (1992). Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell 70:937-948.
  2. Yin, Y., Terauchi, Y., Solomon, G. G., Aizawa, S., Rangarajan, P. N., Yazaki, Y., Kadowaki, T, and Barrett, J. C. (1998). Involvement of p85 in p53-dependent apoptotic response to oxidative stress. Nature 391: 707-710.
  3. Yin, Y.*, Liu, Y. X., Jin, Y. J., Hall, E. J., and Barrett, J. C. (2003). PAC1 phosphatase is a transcription target of p53 in signaling apoptosis and growth suppression. Nature 422:527-531.
  4. Shen, W. H., Balajee, A. B., Wang, J., Wu, H., Eng, C., Pandolfi, P. P., and Yin, Y.*  (2007). Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell 128:157-170.
  5. Liang, H., He, S., Yang, J., Jia, X., Wang, P., Chen, X., Zhang, Z., Zou, X., McNutt, M.A., Shen, W.H.,* and Yin, Y.*. (2014). PTENα is a PTEN isoform Translated through Alternative Initiation and Regulates Mitochondrial Function. Cell Metab. 19, 836-848.
  6. Wang, G., Li, Y., Wang, P., Liang, H., Cui, M., Zhu, M., Guo, L., Su, Q., Sun, Y., McNutt, M.A., and Yin, Y.*. (2015). PTEN regulates RPA1 and protects DNA replication forks. Cell Res. 25, 1189-1204.
  7. Lu, D., Liu, L., Ji, X., Gao, Y., Chen, X., Liu, Y., Liu, Y., Zhao, X., Li, Y., Li, Y., Jin, Y., Zhang, Y., McNutt, M.A., Zhang, Y., and Yin, Y.*(2015).The phosphatase DUSP2 controls the activity of the transcription activator STAT3 and regulates TH17 differentiation. Nat Immunol., 16, 1263-1273.
  8. Feng, J., Liang, J., Li, J., Li, Y., Liang, H., Zhao, X., McNutt, M.A., and Yin, Y.* (2015). PTEN Controls the DNA Replication Process through MCM2 in Response to Replicative Stress. Cell Rep, 13, 1295-1303.
  9. Liang, H., Chen, X., Yin, Q., Ruan, D., Zhao, X., Zhang, C., McNutt MA, and Yin, Y.* (2017). PTENβ is an alternatively translated isoform of PTEN that regulates rDNA transcription. Nature Commun. 8:14771.
  10. Wang P, Mei F, Hu J, Zhu M, Qi H, Chen X, Li R, McNutt MA, Yin, Y*. (2017) PTENα Modulates CaMKII Signaling and Controls Contextual Fear Memory and Spatial Learning. Cell Rep. 19(12):2627-2641.
  11. Li G, Yang J, Yang C, Zhu M, Jin Y, McNutt MA, Yin Y* (2018) PTENα regulates mitophagy and maintains mitochondrial quality control. Autophagy. 14(10): 1742-1760.
  12. Feng J., Dang Y., Zhang W., Zhao X., Zhang C., Hou Z., Jin Y., McNutt MA, Marks AR., Yin Y* (2019). PTEN arginine methylation by PRMT6 suppresses PI3K–AKT signaling and modulates pre-mRNA splicing. PNAS. 116(14):6868-6877.
  13. Li Y., Jin Y., Liu B., Lu D., Zhu M., Jin Y., McNutt MA, Yin Y* (2019). PTENα Promotes Neutrophil Chemotaxis through Regulation of Cell Deformability. Blood. pii: blood-2019-01-899864.
  14. Lu, D., Liu, L., Sun, Y., Song, J., Yin, Q., Zhang, G., Qi, F., Hu, Z., Yang, Z., Zhou, Z., Hu, Y., Zhang, L., Ji, J., Zhao, X., Jin, Y., McNutt, M. A., Yin, Y*. (2020). The phosphatase pac1 acts as a t cell suppressor and attenuates host antitumor immunity. Nat. Immunol. 21, 287-297
  15. Liang, L., Feng, J., Zuo, P., Yang, J., Lu, Y., Yin, Y*. (2020). Molecular basis for assembly of the shieldin complex and its implications for nhej. Nat. Commun. 11, 1972
  16. Zhang, Q., Liang, H., Zhao, X., Zheng, L., Li, Y., Gong, J., Zhu, Y., Jin, Y., Yin, Y*. (2021). Ptenepsilon suppresses tumor metastasis through regulation of filopodia formation. EMBO J. e105806
  17. Sun, Y., Lu, D., Yin, Y., Song, J., Liu, Y., Hao, W., Qi, F., Zhang, G., Zhang, X., Liu, L., Lin, Z., Liang, H., Zhao, X., Jin, Y., Yin, Y*. (2021). Ptenα functions as an immune suppressor and promotes immune resistance in pten-mutant cancer. Nat. Commun. 12, 5147
  18. Wang, G., Yao, H., Gong, Y., Lu, Z., Pang, R., Li, Y., Yuan, Y., Song, H., Liu, J., Jin, Y., Ma, Y., Yang, Y., Nie, H., Zhang, G., Meng, Z., Zhou, Z., Zhao, X., Qiu, M., Zhao, Z., Jiang, K., Zeng, Q., Guo, L., Yin, Y*. (2021). Metabolic Detection and Systems Analyses of Pancreatic Ductal Adenocarcinoma through Machine Learning, Lipidomics and Multi-omics. Science Advances 7, eabh2724.
  19. Wang, G., Qiu, M., Xing, X., Zhou, J., Yao, H., Li, M., Yin, R., Hou, Y., Li, Y., Pan, S., Huang, Y., Yang, F., Bai, F., Nie, H., Di, S., Guo, L., Meng, Z., Wang, J., Yin, Y*. (2022). Systematic analyses of early-stage lung cancer by scRNA-seq and lipidomic reveal aberrant lipid metabolism as detection biomarkers. Science Translational Medicine, 14(630):eabk2756.
  20. Zheng L, Liang H, Zhang Q, Shen Z, Sun Y, Zhao X, Gong J, Hou Z, Jiang K, Wang Q, Jin Y, Yin, Y*. (2022). circPTEN1, a circular RNA generated from PTEN, suppresses cancer progression through inhibition of TGF-β/Smad signaling. Mol Cancer. 21(1):41.
  21. Zhou N, Qi H, Liu J, Zhang G, Liu J, Liu N, Zhu M, Zhao X, Song C, Zhou Z, Gong J, Li R, Bai X, Jin Y, Song Y, Yin Y*.(2022). Deubiquitinase OTUD3 regulates metabolism homeostasis in response to nutritional stresses.Cell Metab. 34(7):1023-1041.e8.
  22. Song J, Zhao W, Zhang X, Tian W, Zhao X, Ma L, Cao Y, Yin Y, Zhang X, Deng X, Lu D. (2022). Mutant RIG-I enhances cancer-related inflammation through activation of circRIG-I signaling. Nat Commun. 13(1):7096.
  23. Liu B, Jin Y, Yang J, Han Y, Shan H, Qiu M, Zhao X, Liu A, Jin Y, Yin Y*.(2022). Extracellular vesicles from lung tissue drive bone marrow neutrophil recruitment in inflammation. J Extracell Vesicles. 11(5):e12223. 
  24. Mu J, Li C, Shi Y, Liu G, Zou J, Zhang DY, Jiang C, Wang X, He L, Huang P, Yin Y, Chen X. (2022). Protective effect of platinum nano-antioxidant and nitric oxide against hepatic ischemia-reperfusion injury. Nat Commun. 13(1):2513. 
  25. Shi P, Ren X, Meng J, Kang C, Wu Y, Rong Y, Zhao S, Jiang Z, Liang L, He W, Yin Y, Li X, Liu Y, Huang X, Sun Y, Li B, Wu C.(2022).Mechanical instability generated by Myosin 19 contributes to mitochondria cristae architecture and OXPHOS. Nat Commun. 13(1):2673.
  26. Mei F, Hu J, Wu Z, Zhang G, Liu A, Li X, Zhu M, Gan Y, Liang L, Zhao X, Yuan Y, Meng X, Li Y, Jin Y, Jia J, Yin Y*.(2022). FAM69C, a kinase critical for synaptic function and memory, is defective in neurodegenerative dementia. Cell Rep. 40(3):111101. 
  27. Yin Q, Li Y, Zhou Z, Li X, Li M, Liu C, Dong D, Wang G, Zhu M, Yang J, Jin Y, Guo L, Yin Y*.(2022). RPA1 controls chromatin architecture and maintains lipid metabolic homeostasis. Cell Rep. 40(2):111071. 
  28. Lu Y., Zuo P., Chen H., Shan H., Wang W., Dai Z., Xu H., Chen Y., Liang L., Ding D., Jin Y., Yin Y.*. (2023). Structural insights into the conformational changes of BTR1/SLC4A11 in complex with PIP2. Nat Commun. 14(1):6157. 
  29. Hao W, Zhang H, Hong P, Zhang X, Zhao X, Ma L, Qiu X, Ping H, Lu D, Yin Y*.(2023). Critical role of VHL/BICD2/STAT1 axis in crystal-associated kidney disease.Cell Death Dis. 14(10):680.
  30. Song J, Liu Y, Yin Y, Wang H, Zhang X, Li Y, Zhao X, Zhang G, Meng X, Jin Y, Lu D, Yin Y*.(2023). PTIR1 acts as an isoform of DDX58 and promotes tumor immune resistance through activation of UCHL5. Cell Rep. 42(11):113388. 

 

*Corresponding author