GUO, Xue

Presidential Young Fellow

Assistant Professor

Education Background

PhD (Fudan University)

B.S. (Wuhan University)

Research Field
Lysosome transport, metabolic signal transduction, and human diseases.
Email
guoxue@cuhk.edu.cn
Biography

Dr. Guo obtained her PhD degree from Fudan University, where she studied key regulatory pathways involved in epigenetics. During her postdoc training at Stanford University, she became fascinated with membrane transport process and focused on lysosomal cystine transport. There she integrated structural, dynamic, and functional studies to investigate the interplay among lysosome transport, cellular signaling and human disease. In 2023, Dr. Guo joined the School of Life and Health Sciences as an Assistant Professor at the Chinese University of Hong Kong, Shenzhen. She is a principal investigator at the Kobilka Institute of Innovative Drug Discovery.

Academic Publications

1. Xue Guo*, Jianxiu Zhang*, Lei Han*, Juliet Lee, Shoshana C. Williams, Allison Forsberg, Yan Xu, Rachel Narehood Austin, and Liang Feng. Structure and mechanism of the alkane-oxidizing enzyme AlkB. Nat. Commun. 14, 2180 (2023).

2. Xue Guo*, Philip Schmiege*, Tufa E. Assafa*, Rong Wang, Yan Xu, Linda Donnelly, Michael Fine, Xiaodan Ni, Jiansen Jiang, Glenn Millhauser, Liang Feng and Xiaochun Li. Structure and mechanism of human cystine exporter cystinosin. Cell. 2022 Sep 29;185(20):3739-3752

3. Xue Guo*, Ling Wang*, Jie Li, Jianxiong Xiao, Xiaotong Yin, Shuang He, Pan Shi, Liping Dong, Zhanyu Ding, Guohong Li, Changlin Tian, Yao Cong, Jiawei Wang, and Yanhui Xu.  Structural insight into autoinhibition and histone H3-induced activation of DNMT3A. Nature. 2015 Jan 29;517(7536):640-4

4. Zhang Y*, Yang H*, Guo X*, Rong N, Song Y, Xu Y, Lan W, Zhang X, Liu M, Xu Y, Cao C.  The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B. Protein Cell. 2014 Jun 22;5(11):837-50

5. Ma H*, Chen H*, Guo X*, Wang Z, Sowa ME, Zheng L, Hu S, Zeng P, Guo R, Diao J, Lan F, Harper JW, Shi YG, Xu Y, Shi Y.  M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability. Proc. Natl Acad. Sci. USA. 2012 Mar 27; 109(13): 4828-33

6. Lei K*, Zhang X*, Ding X, Guo X, Chen M, Zhu B, Xu T, Zhuang Y, Xu R, Han M.  SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice. Proc. Natl Acad. Sci. USA. 2009 Jun 9; 106(25): 10207-12