CUI, Xiaolin

Presidential Young Fellow

Assistant Professor

Education Background

PhD (The University of Adelaide)

Master (The University of Adelaide)

Bachelor (Dalian University of Technology)

Research Field
Biofabrication, Stem cell and acellular therapy, tissue engineering and regenerative medicine, cartilage and bone tissue repair, cardiac tissue engineering
Email
stevencui@cuhk.edu.cn
Biography

As a professional biochemical engineer, Dr. Cui joined the University of Otago as a postdoctoral Fellow after completing his PhD from the University of Adelaide in 2017. He was later promoted to Research Fellow in 2019. In 2021, he was appointed as an adjunct associate professor at the Department of Bone and Joint, The First Affiliated Hospital of Dalian Medical University. In July 2022, he joined the School of Medicine as an Assistant Professor at CUHKSZ.

Dr. Cui specializes in the interface of stem cells, biomaterials, biofabrication, and tissue engineering. He has a special interest in cartilage and bone regeneration, as well as cardiovascular disease diagnosis and treatment. His expertise includes polymer synthesis, tissue culture, anticancer drug screening, drug and gene delivery systems, and stem cell therapy. Currently, he is leading several pre-clinical trials in the field of tissue engineering.

Dr. Cui has received the 2021 WFIRM Young Investigator Award from the International Society for Biofabrication. Additionally, he has received a provisional PhD scholarship from the University of Adelaide, University of Otago Divisional Health Science Postdoctoral Fellowship, National Heart Foundation of New Zealand Research Fellowship, New Zealand Ministry for Business, Innovation and Employment (MBIE) Science Whitinga fellowship, and New Zealand Foundational Advice Emerging Researcher Award. As a Principal Investigator (PI), Dr. Cui has also received an Explorer Grant from the Health Research Council and a major project grant from the Heart Foundation。

Dr. Cui is a member of the Royal Society of New Zealand (RSNZ), the Royal Society of Chemistry, the American Chemical Society, the International Society for Biofabrication (ISBF), and is the emerging researcher representative (NZ) of the Australasian Society for Biomaterials and Tissue Engineering (ASBTE). He represented New Zealand at the 2022 Global Young Scientists Summit. Currently, he serves as an associate editor of Frontiers in Biomaterials Science and is a part of the early career researcher (ECR) editorial boards of Exploration (Weily), Military Medical Research (BMC, Spring Nature), and Extracellular Vesicles and Circulating Nucleic Acids (EVCNA). He has also acted as a guest editor for Frontiers in Bioengineering and Biotechnology. Dr. Cui is an invited reviewer for over 20 SCI index journals, including Science Advances, Advanced Materials, Advanced Functional Materials, Bioactive Material, Small, Advanced Healthcare Materials, and Acta Biomaterialia, among others.

Academic Publications

Journal articles

  1. Z. Fu, K. Fan, X. He, Q. wang, J. Yuan, K. Lim, J. Tang, F. Xie, X. Cui*, Single-atom-based nano-enzyme in tissue repair, ACS Nano, 2024, accepted. Last Author
  2. X. Cui, J. Guo, P. Yuan, Y. Dai, P. Du, F. Yu, Z. Sun, J. Zhang, J. Tang, K. Cheng, Bio-Derived Nanoparticles for Cardiac Repair, ACS Nano, 2024, accepted.
  3. Z. Bao, S. Lu, D. Zhang, G. Wang, X. Cui*, G. Liu*, Wearable microneedle patch for colorimetric detection of multiple signature biomarkers in vivo towards diabetic diagnosis, Advanced Healthcare Materials, 2024, 2303511. Co-corresponding author.
  4. P. Du, Y. Hou, C. Su, J. Gao, Y. Yang, J. Zhang, X. Cui* and J. Tang, The future for the therapeutics of Abdominal Aortic Aneurysm: Engineered Nanoparticles Drug Delivery for Abdominal Aortic Aneurysm, Frontiers in Bioengineering and Biotechnology, 2024, online. Co-corresponding author.
  5. S. Zou, J. Li, S. Lu, D. Li, Y. Liu, W. Zhang, X. Cui, J. Gooding, K. Tian, G. Liu, CRISPR/Cas12a immunosensing on glass fiber for point-of-care quantifying multiple inflammation biomarkers in osteoarthritis, Device, 2024, online. Cover Article.
  6. H. Cao, S. Deng, X. Chen, X. Cui, T. Yuan, J. Liang, X, Zhang, Y. Fan, Q. Wang, An injectable cartilage-coating composite with long-term protection, effective lubrication and chondrocyte nourishment for osteoarthritis treatment, Acta Biomaterialia, 2024, online.
  7. M. Chen, Y. Lu, Y. Liu, Q. Liu, S. Deng, Y. Liu, X. Cui, J. Liang, Y. Fan, Q. Wang, X. Zhang, Injectable microgels with hybrid exosomes of chondrocyte-targeted FGF18 gene-editing and self-renewable lubrication for osteoarthritis therapy, Advanced Materials, 2024, online.
  8. F. Xie#, X. Cui#, X. Zhi, D. Yao, B. Johannessen, Q. Zhang, J. Tang, T. Woodfield, L. Gu and S. Qiao, A 3D- Printing Synthesis of Single Atom Catalysts, Nature Synthesis, 2023, 2, 129-139. Co-first author.
  9. Y. Dai, K. Qiao, D. Li, P. Isingizwe, H. Liu, Y. Liu, K. Lim, T. Woodfield, G. Liu, J. Hu, J. Yuan*, J. Tang*, X. Cui* Plant-derived biomaterials and their potential in cardiac tissue repair, Advanced Healthcare Materials, 2023, 2202827. Last author.
  10. D. Li, G. Zhang, J. Guo, Y. Liu, Y Lu, Z Qin, Y. Xu, C. Cao, B. Wang, Q. Guo, Y. Wang, G. Liu, X. Cui*, J. Zhang*, J. Tang*, Idebenone attenuates ferroptosis by inhibiting excessive autophagy via the ROS-AMPK-mTOR pathway to preserve cardiac function after myocardial infarction, European Journal of Pharmacology, 2023, 943, 175569. Co-corresponding author.
  11. K. Qiao, XY.Cui, J. Gao, F. Yu, H. Liu, Y. Dai, J. Liu, X. Yang, X. Xian, J. Hu, J. Tang*, X. Cui*, Roles of Extracellular Vesicles Derived from Immune Cells in Atherosclerosis, Extracellular Vesicle, 2023, 2, 100028. Last Author.
  12. H. Gao, M. Chen, X. Cui, Y. Liu, S. Deng, T. Yuan, Y. Fan, Q. Wang, X. Zhang, Cell-Free Osteoarthritis Treatment with Sustained-Release of Chondrocyte-Targeting Exosomes from Umbilical Cord-Derived Mesenchymal Stem Cells to rejuvenate ageing chondrocytes, ACS Nano, 2023, 17,13358.
  13. Z. Huang, M. Guang, Z. Bao, F. Dong, X. Cui, G. Liu, Ligand Mediation for Tunable and Oxide Suppressed Surface Gold-Decorated Liquid Metal Nanoparticles, Small, 2023, 2306652. Cover article.
  14. M. Ho, Q. Hilst, X.Cui, Y. Ramaswamy, T. Woodfield, J. Rnjak-Kovacina, S. Wise, K. Lim, From Adhesion to Detachment: Strategies to Design Tissue Adhesive Hydrogels, Advanced Nanobiomed Research, 2023, online.
  15. Y. Yang, J. Gao, Z. Qin, Y. Lu, Y. Xu, J. Guo, X. Cui, J. Zhang*, J. Tang*, The Present Clinical Treatment and Future Emerging Interdisciplinary for Heart Failure: Where we are and What we can do, Intensive Care Research, 2023, 3, 3-11.
  16. Y. Liu, S. Lu, Z. Zhang, Z. Yang, X. Cui, G. Liu*, Printable biosensors towards next generation point-of-care testing: paper substrate as an example, Lab on a Chip, 2023, 23, 3353.
  17. Z.Zou, H. Li, K. Yu, K. Ma, Q. Wang, J. Tang, G. Liu, K. Lim, G. Hooper, T. Woodfield, X. Cui*, W. Zhang*, K. Tian*, The potential role of synovial cells in the progression and treatment of osteoarthritis, Exploration, 2023, 20220132. Co-corresponding author. Cover article.
  18. C. Su, Y. Lu, Z. Wang, J. Guo, Y. Hou, X. Wang, Z. Qin, J. Gao, Z. Sun, Y. Dai, Y. Liu, G. Liu, X. Xian, X. Cui*, J. Zhang*, J. Tang*, Atherosclerosis: The Involvement of Immunity, Cytokines and Cells in Pathogenesis, and Potential Novel Therapeutics, Aging and Disease, 2023, 14,1214. Co-corresponding author.
  19. G. Zhang, X. Cui, Z. Qin, Z. Wang, Y. Lu, Y. xU, S. Xu, L. Tang, L. Zhang, G. Liu, X. Wang, J. Zhang and J. Tang, Atherosclerotic plaque vulnerability quantification system for clinical and biological interpretability , iSciene, 2023, 26, 107587.
  20. S Deng, H Cao, X Cui, Y Fan, Q Wang, X Zhang, Optimization of exosome-based cell-free strategies to enhance endogenous cell functions in tissue regeneration, Acta Biomaterialia, 2023, online.
  21. X. Cui#,*, C. Alcala-Orozco#, K. Baer, J. Lin, C. Murphy, M. Durham, G. Hooper, K. Lim and T. Woodfield*, 3D bioassembly of cell-instructive microgel spheroid bioinks for hybrid biofabrication of allogeneic tissue-engineered osteochondral constructs, Biofabrication, 2022, 14, 034101. Co-corresponding author.
  22. K. Qiao, L. Xu, J. Tang, Q. Wang, K. Lim, G. Hooper, T. Woodfield, G. Liu, K. Tian*, W. Zhang* and X. Cui*, Advances in Nanomedicine for Cartilage and Bone repair, Journal of Nanobiotechnology, 2022, 20(1), 1-42. Last author.
  23. Z. Wang, Z. Qin, R. Yuan, S. Xu, Y. Lv, F. Yu, L. Tang, L. Zhang, J. Bai, X. Cui*, J. Zhang*, and J. Tang*, Systemic immune‐inflammation index as a prognostic marker for advanced chronic heart failure with renal dysfunction, ESC Heart Failure, 2022, 10 (1), 478-491 Co-corresponding author
  24. D. Li, T. Kang, J. Guo, Q. Wang, Z. Qin, Y. Lu, Y. Xu, N. Scott, C. Charles, G. Liu, J. Zhang*, X. Cui* and J. Tang*, Growth factors: avenue for the treatment of myocardial infarction and their delivery strategies, Regenerative Medicine, 2022, 17, 561-579. Co-corresponding author
  25. J. Li, X. Cui, G. Lindberg, C. Alcala-Orzco, G. Hooper, K. Lim and T. Woodfield, Integration of Ti-6Al-4V implants with vascular bioinks for vascularized bone regeneration, Biofabrication, 2022, 14, 034103.
  26. Y. Hou, X. Cui, Z. Qin, C. Su, G. Zhang, J, Tang, J. Li and J. Zhang, Three0dimensional bioprinting for artificial blood vessel: process, bioinks and challenges, International Journal of Bioprinting, 2023, online.
  27. J. Tang, S. Xu, Z. Qin, R. Yuan, X. Cui, Z. Wang, F. Yu, Y. Lv, J. Zhang, L. Zhang, J. Bai, G. Liu, The haemoglobin glycation index predicts the risk of adverse cardiovascular adverse events in coronary heart disease patients with type 2 diabetes mellitus, Frontiers in Cardiovascular Medicine, 2022, 9, 992252.
  28. G. Zhang, X. Cui, L. Zhang, W. Wang, G. Liu, X. Zhu, J. Shangguan, W. Zhang, Y. Zhang, J Tang and J. Zhang, Uncovering pathogenic and genetic link of SARS-CoV-2 infections on heart failure comorbidity, ESC Heart Failure, 2022, 9, 2937-2954.
  29. S. Zou, H. Wei, X. Cui, W. C. Mak, and G. Liu, Intercalating methyl blue to molecular beacon for sensitive detection of salivary TNF-α towards early diagnosis of oral cancer, Sensors & Diagnostics, 2022, 1, 731-738.
  30. Y. Dai, X. Cui, G. Zheng, A. Mohsin, H. Xu, Y. Zhang and M. Guo, Development of a novel feeding regime for large scale production of human umbilical cord mesenchymal stem cells, Cytotechnology, 2022, 74, 351-369 .
  31. J. Tang#,*, X. Cui#,*, Z. Zhang#, Y. Xu, Y. Lu, Q. Wang, H. Zhang, K. Lim, T. Woodfield and J. Zhang*, Injection-free delivery of MSC-derived extracellular vesicles for myocardial infarction therapeutics, Advanced Healthcare Materials, 2022, 11(5), 2100312.Co-first and corresponding author
  32. Y. Lu#, X. Cui#, L. Zhang, Y. Xu, Z. Qin, G. Liu, Q. Wang, K. Tian, J. Zhang and J. Tang, The functional role of lipoproteins in Atherosclerosis: a novel direction of diagnosis and targeted therapy, Aging and disease, 2020, 13(2), 491. Co-first author
  33. C. Alcala-Orozco, I. Mutrejia, X. Cui, G. Hooper, K. Lim and T. Woodfield, Development of nanocomposite Mg-PCL biomaterial inks for hybrid biofabrication of skeletal regenerative 3D construct, Bone, 2022, 154, 116198.
  34. H. Cao, X. Wang, X. Cheng, Y. Liu, X. Cui, J. Liang, Q. Wang, Y. Fan and X. Zhang, Childhood cartilage ECM enhances the chondrogenesis of endogenous cells and subchondral bone repai of the unidirectional collagen-dECM scaffold in combination with microfracture, ACS Applied Materials and Interfaces, 2021, 13(48), 57043.
  35. G. Lindberg, X. Cui, M. Durham, L. Doornkamp-Veenendaal, B. Schon, G. Hooper, K. Lim, and T. Woodfield, Probing Multicellular Tissue Fusion of Co-Cultured Spheroids - a 3D Bioassembly Model, Advanced Sciences, 2021, 8(22), 2103320.
  36. H. Kim#, B. Kang#, X. Cui#, S. Lee, D. Cho, T. Woodfield, K. Lim and J. Jang, Light-activated decellularized extracellular matrix-based bioink for volumetric tissue analogs in centimeter-scale, Advanced Functional Material, 2021, 31(32), 2011252. Co-first author. Cover article
  37. E. Aldrich#, X. Cui#, C. Murphy#, K. Lim, G. Hooper, W. McIlwraith, and T. Woodfield, Allogeneic mesenchymal stromal cells for cartilage regeneration: A review on in vitro evaluation, clinical experience and translational opportunities, Stem Cells Translational Medicine, 2021, 10(11), 1500. Co-first author.
  38. K. Qiao, Q. Chen, Y. Cao, J. Li, G. Xu, X. Cui*, K. Tian* and W. Zhang*, Diagnostic and therapeutic role of extracellular vesicle in articular cartilage lesions and degenerative joint disease, Frontiers in Bioengineering and Biotechnology, 2021, 9, 698614. Co-corresponding author.
  39. M. Li, F. Ren, J. Tian, K. Yang, H. Song, X. Cui, D. Yin, The evaluation of electrocardiogram and echocardiographic characteristics of the Pre- and Post-operation of his bundle pacing: a comprehensive review and meta-analysis, Anatolian Journal of Cardiology, 2021, 25(12), 845.
  40. Y. Liu, Y. Wang, H. Zhang, Z. Tang, X. Cui, W. Li, J. Liang, Q. Wang, Y. Fan, X. Zhang, solubilized cartilage ECM facilitates the recruitment and chondrogenesis of endogenous BMSCs in collagen scaffold for enhancing microfracture treatment, ACS Applied Materials& Interface, 2021, 13(21), 24553.
  41. Z. Zhang, J. Tang, X. Cui, B. Qin, J. Zhang, L. Zhang, H. Zhang, G. Liu, W. Wang and J. Zhang, New insights and novel therapeutic potentials for macrophages in myocardial infarction, Inflammation, 2021, 44(5), 1696.
  42. C. Alcala-Orzco, X. Cui, G. Hooper, K. Lim and T. Woodfield, Convergent functionality: Strategies for 3D hybrid-construct biofabrication and the role of composite biomaterials for skeletal regeneration, Acta Biomaterialia, 2021, 132,188.
  43. J. Zhang#, X. Cui#, J. Guo, C. Cao Z. Zhang, B. Wang, L. Zhang, D. Shen, K. Lim, T. Woodfield, J. Tang and J. Zhang, Small but significant: Insights and New Perspectives of Exosomes in Cardiovascular Disease, Journal of Cellular and Molecular Medicine, 2020, 24, 8291.  Co-first author
  44. X. Cui, J. Li, Y. Hartanto, M. Durham, J. Tang, H. Zhang, G, Hooper, K. Lim and T. Woodfield, Advances in Extrusion 3D Bioprinting: A Focus on Multicomponent Hydrogel-based Bioinks, Advanced Healthcare Materials, 2020, 9, 1901648.
  45. P. Atienza-Roca, D. Kieser, X. Cui, R. Yogambha, G. Hooper, A. Clarkson, J. Rnjak-Kovacina, P. Martens, L. Wise, T. Woodfield and K. Lim, Visible Light Mediated PVA-Tyramine Hydrogels for Covalent Incorporation and Controlled Release of Functional Growth Factors, Biomaterials Science, 2020, 8, 5005. Editor selected hot article. Cover article.
  46. K. Lim, J. Galarraga, X. Cui, G. Lindberg, J. Burdick, T. Woodfield, Fundamentals and Applications of Photocrosslinking in Bioprinting, Chemical Reviews, 2020, 120, 10662.
  47. X. Cui, B. Soliman, C. Alcala-Orzco, J. Li, M. Vis, M. Santo, S. Wise, R. Levato, J. Malda, T. Woodfield, J. Rnjak-Kovacina and K. Lim, Rapid Photo-Crosslinking of Silk Hydrogels with High Cell-Density and Enhanced Shape Fidelity, Advanced Healthcare Materials, 2020, 9,1901667.
  48. M. Baptista, H. Joukhdar, C. Alcala-Orozco, K. Lai, S. Jiang, X. Cui, S. He, F. Tang, C. Heu, T. Woodfield, K. Lim and J. Rnjak-Kovacina, Silk fibroin photo-lyogels containing microchannels as a biomaterial platform for in situ tissue engineering, Biomaterials Science, 2020, 8, 7093.
  49. J. Li, X. Cui, G. Hooper, K. Lim and T. Woodfield, Rational design, bio-functionalization and biological performance of hybrid additive manufactured titanium implants for orthopaedic applications: a review, Journal of the Mechanical Behavior of Biomedical Materials, 2020,103671.
  50. C. Alcala-Orzco, I. Mutreja, X. Cui, K. Lim and T. Woodfield, Design and Characterization of multi-functional strontium-gelatin nanocomposite bioinks with improved print fidelity and osteogenic capacity, Bioprinting, 2020, 18, e00073.
  51. J. Zhang, J. Tang, X. Cui, B. Wang, M. Bu, Y. Bai, K. Wang, J. Guo, D. Shen, J. Zhang, Indirect comparison of novel oral anticoagulants among Asians with non-valvular atrial fibrillation in the real world setting: a network meta-analysis, BMC Cardiovascular Disorders, 2019, 19, 182.
  52. Y. Hartanto, M. Zargar, X. Cui, B. Jin and S. Dai, Non-ionic copolymer microgels as high-performance draw materials for forward osmosis desalination, Journal of Membrane Science, 2019, 572, 480-488.
  53. X. Cui, J. Tang, Y. Hartanto, J. Bi, S. Dai, K. Cheng, SZ. Qiao and H. Zhang, NIPAM-based microgel microenvironment regulates cardiac stromal cells for myocardial infarction treatment, ACS Applied material & Interface, 2018, 10(44), 37783-37796.
  54. X. Cui, Y. Hartanto, J. Bi, S. Dai and H. Zhang, Tuning microenvironment for multicellular spheroid formation in thermo-responsive anionic microgel scaffolds, Journal of Biomedical Materials Research Part A, 2018, 106(11), 2899-2909.
  55. J. Guo, J. Tang, X. Cui, L. Zhang, H. Zhang, C. Cao, B. Wang and J, Zhang, Elevated Red Cell Distribution Width is Associated with Poor Clinical Outcomes in No-Ischemic Dilated Cardiomyopathy, International Journal of Clinical and Experimental Medicine, 2018, 11(8), 8102-8109.
  56. A. Mohammad, X. Cui, H. Zhang and F. Young, Three dimensional in vitro culture of murine secondary follicles in a defined synthetic matrix, Journal of Biomaterials and Nanotechnology, 2018, 9, 244-262.
  57. J. Tang, J. Cores, K. Huang, X. Cui, L. Luo, J. Zhang, T. Li, L. Qian and K. Cheng, Concise Review: Is Cardiac Cell Therapy Dead? Embarrassing Trial Outcomes and New Directions for the Future, Stem Cells Translational Medicine, 2018, 7, 354-359.
  58. J. Tang#, X. Cui#, T. Caranasos, M. Hensley, A. Vandergriff, Y. Hartanto, J. Zhang, H. Zhang and K. Cheng, Heart Repair Using Nanogel-Encapsulated Human Cardiac Stem Cells in Mice and Pigs with Myocardial Infarction, ACS Nano, 2017, 11, 9738-9749. Editor choice. Co-first author.
  59. X. Cui, Y. Hartanto, H. Zhang, Advances in multicellular spheroids formation, Journal of the Royal Society Interface, 2017, 14, 20160877. Top 10 most cited article in 2018 & 2019.
  60. L. Yan, X. Cui, T. Harada, S. Lincoln, S. Dai and T, Kee, Generation of Fluorescent and Stable Conjugated Polymer Nanoparticles with Hydrophobically Modified Poly(acrylate)s, Macromolecules, 2016, 49, 8530-8539.
  61. X. Cui, Y. Liu, Y. Hartanto, J. Bi, S. Dai and H. Zhang, Multicellular spheroids formation and recovery in microfluidics-generated thermoresponsive microgel droplets. Colloid and Interface Science Communications, 2016, 14, 4-7.
  62. X. Cui, S. Dini, S. Dai, J. Bi, B. J. Binder, J. E. F. Green and H. Zhang, A mechanistic study on tumour spheroids formation in thermosensitive hydrogels: experiments and mathematical modelling, RSC Advances, 2016, 6, 73282-73291.
  63. Y. Hartanto, M. Zargar, X. Cui, Y. Shen, B. Jin and S. Dai, Thermoresponsive cationic copolymer microgels as high-performance draw agents in forward osmosis desalination, Journal of Membrane Science, 2016, 518, 273-281.
  64. Y. Liu, Z. Wang, L. Lia, X. Cui, J. Chua, S. Zhang and Y. Zhuang, On-line monitoring the aggregate size distribution of Carthamustinctorius L. cells with multi-frequency capacitance measurements, RSC Advances, 2016, 6, 89764 - 89769.
  65. H. Zhang, X. Cui, S. Dai, J. Bi, Single-cell analysis for bioprocessing, Engineering in Life Sciences, 2015, 15, 582–592.