Ph.D. (The University of Hong Kong)

B.Sc./M.Sc (Fujian Agriculture and Forestry University)

Dr. WANG started to learn Bioinformatics since 2005 and obtained Bachelor’s and Master’s degrees at Fujian Agriculture and Forestry University. He continued his study at the University of Hong Kong and received the Ph.D. in Bioinformatics and Genetics in 2016. He focuses on the study of large-scale Omics data, especially in the field of autoimmune diseases. He has participated in many international and nation-wide collaborations and these works identified more than 130 genetic loci associated with systemic lupus erythematosus (SLE) during postdoctoral training. Together with functional genomic data from public domains, his works revealed cell type-specific regulation for the disease-associated genes. These findings significantly improved the understanding of disease pathogenesis. So far, he has published 32 papers at peer-reviewed journals, including Nature Genetics, Nature Communications, Annals of the Rheumatic Diseases and Arthritis & Rheumatology et al. Dr. Wang joined the school of Life and Health Science & Faculty of Medicine at the Chinese University of Hong Kong (Shenzhen) as assistant professor in 2022. Dr. Wang’s future works would focus on how to translate real-world big data into clinical applications, with the aims of facilitating drug discovery and improving accuracy of genetic screening for both mendelian and complex diseases. 

Year 2022

1. W. Ma, Y. L. Lau, W. Yang and Y. F. Wang (2022). "Random Forests Algorithm Boosts Genetic Risk Prediction of Systemic Lupus Erythematosus" Front Genet 15 August 2022 doi.org/10.3389/fgene.2022.902793.
2. P. Tian, T. H. Chan, Y. F. Wang, W. Yang, G. Yin and Y. D. Zhang  (2022). “Multiethnic polygenic risk prediction in diverse populations through transfer learning” Front Genet 19 August 2022 doi.org/10.3389/fgene.2022.906965.
3. Y. F. Wang, W. Wei, P. Tangtanatakul, L. Zheng, Y. Lei, Z. Lin, C. Qian, X. Qin, F. Hou, X. Zhang, L. Shao, N. Satproedprai, S. Mahasirimongkol, P. Pisitkun, Q. Song, Y. L. Lau, Y. Zhang, N. Hirankarn and W. Yang (2022). "Identification of Shared and Asian-Specific Loci for Systemic Lupus Erythematosus and Evidence for Roles of Type III Interferon Signaling and Lysosomal Function in the Disease: A Multi-Ancestral Genome-Wide Association Study" Arthritis & Rheumatology. 74(5):840-848.
4. Q. Zhang, Y. F. Wang, X. Hu, Y. Tan, C. Gao, J. Chen, F. Han, J. Chen and Y. Yang (2022). "Association of serum cardiac troponin I and severity of coronary stenosis in patients with varied renal functions: a retrospective cohort study" BMJ Open 12(3):e054722. (Co-first authorship)
5. T. Zhou, X. Zhu, Z. Ye, Y. F. Wang, C. Yao, N. Xu, M. Zhou, J. Ma, Y. Qin, Y. Shen, Y. Tang, Z. Yin, H. Xu, Y. Zhang, X. Zang, H. Ding, W. Yang, Y Guo, J. Harley, B. Namjou, K. Kaufman, L. Kottyan, M. Weirauch, G. Hou and N. Shen (2022). "Lupus enhancer risk variant causes dysregulation of IRF8 through cooperative lncRNA and DNA methylation machinery" Nat Commun. 13(1):1855.
6. X. Yin, K. Kim, H. Suetsugu, S.Y. Bang, L. Wen, M. Koido, E. Ha, L. Liu, Y. Sakamoto, S. Jo, R.X. Leng, N. Otomo, Y.C. Kwon, Y. Sheng, N. Sugano, M.Y. Hwang, W. Li, M. Mukai, K. Yoon, M. Cai, K. Ishigaki, W.T. Chung, H. Huang, D. Takahashi, S.S. Lee, M. Wang, K. Karino, S.C. Shim, X. Zheng, T. Miyamura, Y.M. Kang, D. Ye, J. Nakamura, C.H. Suh, Y. Tang, G. Motomura, Y.B. Park, H. Ding, T. Kuroda, J. Choe, C. Li, H. Niiro, Y. Park, C. Shen, T. Miyamoto, G. Ahn, W. Fei, T. Takeuchi, J. Shin, K. Li, Y. Kawaguchi, Y. Lee, Y. F. Wang, K. Amano, D.J. Park, W. Yang, Y. Tada, Y.L. Lau, K. Yamaji, Z. Zhu, M. Shimizu, T. Atsumi, A. Suzuki, T. Sumida, Y. Okada, K. Matsuda, K. Matsuo, Y. Kochi, K. Yamamoto, K. Ohmura, T. Kim, S. Yang, T. Yamamoto, B. Kim, N. Shen, S. Ikegawa, H. Lee, X. Zhang, C. Terao, Y. Cui, S.C. Bae (2022). “Biological insights into systemic lupus erythematosus through an immune cell-specific transcriptome-wide association study” Ann Rheum Dis. 81(9):1273-1280.  doi: 10.1136/annrheumdis-2022-222345.

Year 2021

7. Y. F. Wang, Y. Zhang, Z. Lin, H. Zhang, T. Y. Wang, Y. Cao, D. L. Morris, Y. Sheng, X. Yin, S. L. Zhong, X. Gu, Y. Lei, J. He, Q. Wu, J. J. Shen, J. Yang, T. H. Lam, J. H. Lin, Z. M. Mai, M. Guo, Y. Tang, Y. Chen, Q. Song, B. Ban, C. C. Mok, Y. Cui, L. Lu, N. Shen, P. C. Sham, C. S. Lau, D. K. Smith, T. J. Vyse, X. Zhang, Y. L. Lau and W. Yang (2021). "Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups." Nat Commun. 12(1): 772.
8. Q. Song, Y. Lei, L. Shao, W. Li, Q. Kong, Z. Lin, X. Qin, W. Wei, F. Hou, J. Li, X. Guo, Y. Mao, Y. Cao, Z. Liu, L. Zheng, R. Liang, Y. Jiang, Y. Liu, L. Zhang, J. Yang, Y. L. Lau, Y. Zhang, B. Ban, Y. F. Wang and W. Yang (2021). "Genome-wide association study on Northern Chinese identifies KLF2, DOT1L and STAB2 associated with systemic lupus erythematosus." Rheumatology (Oxford). (Co-first authorship)
9. Y. Zhang, Y. F. Wang, H. Rasheed and J. Ott (2021). "Multi-Omics Study in Revealing Underlying Pathogenesis of Complex Diseases: A Translational Perspective." Front Genet 12: 789294.
10. X. Yin, K. Kim, H. Suetsugu, S. Y. Bang, L. Wen, M. Koido, E. Ha, L. Liu, Y. Sakamoto, S. Jo, R. X. Leng, N. Otomo, V. Laurynenka, Y. C. Kwon, Y. Sheng, N. Sugano, M. Y. Hwang, W. Li, M. Mukai, K. Yoon, M. Cai, K. Ishigaki, W. T. Chung, H. Huang, D. Takahashi, S. S. Lee, M. Wang, K. Karino, S. C. Shim, X. Zheng, T. Miyamura, Y. M. Kang, D. Ye, J. Nakamura, C. H. Suh, Y. Tang, G. Motomura, Y. B. Park, H. Ding, T. Kuroda, J. Y. Choe, C. Li, H. Niiro, Y. Park, C. Shen, T. Miyamoto, G. Y. Ahn, W. Fei, T. Takeuchi, J. M. Shin, K. Li, Y. Kawaguchi, Y. K. Lee, Y. F. Wang, K. Amano, D. J. Park, W. Yang, Y. Tada, K. Yamaji, M. Shimizu, T. Atsumi, A. Suzuki, T. Sumida, Y. Okada, K. Matsuda, K. Matsuo, Y. Kochi, H. Japanese Research Committee on Idiopathic Osteonecrosis of the Femoral, L. C. Kottyan, M. T. Weirauch, S. Parameswaran, S. Eswar, H. Salim, X. Chen, K. Yamamoto, J. B. Harley, K. Ohmura, T. H. Kim, S. Yang, T. Yamamoto, B. J. Kim, N. Shen, S. Ikegawa, H. S. Lee, X. Zhang, C. Terao, Y. Cui and S. C. Bae (2021). "Meta-analysis of 208370 East Asians identifies 113 susceptibility loci for systemic lupus erythematosus." Ann Rheum Dis. 80(5):632-640. doi: 10.1136/annrheumdis-2020-219209.
11. M. Zhou, R. Guo, Y. F. Wang, W. Yang, R. Li and L. Lu (2021). "Application of Weighted Gene Coexpression Network Analysis to Identify Key Modules and Hub Genes in Systemic Juvenile Idiopathic Arthritis." Biomed Res Int 2021: 9957569.
12. Y. Zhang, X. Zhou, Y. Wang, X. Liu, Y. F. Wang, Y. Lau, W. Yang and H. Zhang (2021). "Shared genetic study gives insights into the shared and distinct pathogenic immunity components of IgA nephropathy and SLE." Molecular Genetics and Genomics. 296(4):1017-1026. doi: 10.1007/s00438-021-01798-7.

Year 2020

13. T. Wang, Y. F. Wang, Y. Zhang, J. J. Shen, M. Guo, J. Yang, Y. L. Lau and W. Yang (2020). "Identification of Regulatory Modules That Stratify Lupus Disease Mechanism through Integrating Multi-Omics Data." Mol Ther Nucleic Acids 19: 318-329.
14. L. Chen, Y. F. Wang, L. Liu, A. Bielowka, R. Ahmed, H. Zhang, P. Tombleson, A. L. Roberts, C. A. Odhams, D. S. Cunninghame Graham, X. Zhang, W. Yang, T. J. Vyse and D. L. Morris (2020). "Genome-wide assessment of genetic risk for systemic lupus erythematosus and disease severity." Human Molecular Genetics. 29(10):1745-1756.  doi: 10.1093/hmg/ddaa030.
15. P. Tangtanatakul, C. Thumarat, N. Satproedprai, P. Kunhapan, T. Chaiyasung, S. Klinchanhom, Y. F. Wang, W. Wei, J. Wongshinsri, D. Chiewchengchol, P. Rodsaward, P. Ngamjanyaporn, T. Suangtamai, S. Mahasirimongkol, P. Pisitkun and N. Hirankarn (2020). "Meta-analysis of genome-wide association study identifies FBN2 as a novel locus associated with systemic lupus erythematosus in Thai population." Arthritis Res Ther 22(1): 185.
16. F. Zhang, Y. F. Wang, Y. Zhang, Z. Lin, Y. Cao, H. Zhang, Z. Y. Liu, D. L. Morris, Y. Sheng, Y. Cui, X. Zhang, T. J. Vyse, Y. L. Lau, W. Yang and Y. Chen (2020). "Independent Replication on Genome-Wide Association Study Signals Identifies IRF3 as a Novel Locus for Systemic Lupus Erythematosus." Front Genet 11: 600.

Year 2019

17. Y. F. Wang, Y. L. Lau and W. Yang (2019). "Genetic studies on systemic lupus erythematosus in East Asia point to population differences in disease susceptibility." Am J Med Genet C Semin Med Genet.
18. J. Shen, Y. F. Wang and W. Yang (2019). "Sex-Interacting mRNA- and miRNA-eQTLs and Their Implications in Gene Expression Regulation and Disease." Front Genet 10: 313.

Year 2018

19. Y. F. Wang, Y. Zhang, Z. Zhu, T. Y. Wang, D. L. Morris, J. J. Shen, H. Zhang, H. F. Pan, J. Yang, S. Yang, D. Q. Ye, T. J. Vyse, Y. Cui, X. Zhang, Y. Sheng, Y. L. Lau and W. Yang (2018). "Identification of ST3AGL4, MFHAS1, CSNK2A2 and CD226 as loci associated with systemic lupus erythematosus (SLE) and evaluation of SLE genetics in drug repositioning." Ann Rheum Dis.
20. J. Shen, C. Yang, Y. F. Wang, T. Y. Wang, M. Guo, Y. L. Lau, X. Zhang, W. Yang and Y. Sheng (2018). "HLA-IMPUTER: an easy to use web application for HLA imputation and association analysis using population-specific reference panels." Bioinformatics. Apr 1;35(7):1244-1246.
21. H. Zhang, Y. Zhang, Y. F. Wang, D. Morris, N. Hirankarn, Y. Sheng, J. Shen, H. F. Pan, J. Yang, S. Yang, Y. Cui, D. Q. Ye, T. J. Vyse, X. Zhang, Y. L. Lau and W. Yang (2018). "Meta-analysis of GWAS on both Chinese and European populations identifies GPR173 as a novel X chromosome susceptibility gene for SLE." Arthritis Res Ther 20(1): 92.

Before 2018

22. D. Morris, Y. Sheng, Y. Zhang, Y. F. Wang, Z. Zhu, P. Tombleson, L. Chen, D. S. Cunninghame Graham, J. Bentham, A. L. Roberts, R. Chen, X. Zuo, T. Wang, L. Wen, C. Yang, L. Liu, L. Yang, F. Li, Y. Huang, X. Yin, S. Yang, L. Ronnblom, B. G. Furnrohr, R. E. Voll, G. Schett, N. Costedoat-Chalumeau, P. M. Gaffney, Y. L. Lau, X. Zhang, W. Yang, Y. Cui and T. J. Vyse (2016). "Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus." Nat Genet.
23. Y. Zhang, J. Yang, J. Zhang, L. Sun, N. Hirankarn, H. F. Pan, C. S. Lau, T. M. Chan, T. L. Lee, A. M. Leung, C. C. Mok, L. Zhang, Y. F. Wang, J. J. Shen, S. N. Wong, K. W. Lee, M. H. Ho, P. P. Lee, B. H. Chung, C. Y. Chong, R. W. Wong, M. Y. Mok, W. H. Wong, K. L. Tong, N. K. Tse, X. P. Li, Y. Avihingsanon, P. Rianthavorn, T. Deekajorndej, K. Suphapeetiporn, V. Shotelersuk, S. K. Ying, S. K. Fung, W. M. Lai, C. M. Wong, I. O. Ng, M. M. Garcia-Barcelo, S. S. Cherny, Y. Cui, P. C. Sham, S. Yang, D. Q. Ye, X. J. Zhang, Y. L. Lau and W. Yang (2015). "Genome-wide search followed by replication reveals genetic interaction of CD80 and ALOX5AP associated with systemic lupus erythematosus in Asian populations." Ann Rheum Dis.
24. Y. Zhang, Y. F. Wang, J. Yang, J. Zhang, L. Sun, N. Hirankarn, H. F. Pan, C. S. Lau, T. M. Chan, T. L. Lee, A. M. Leung, C. C. Mok, L. Zhang, J. J. Shen, S. N. Wong, K. W. Lee, M. H. Ho, P. P. Lee, B. H. Chung, C. Y. Chong, R. W. Wong, M. Y. Mok, W. H. Wong, K. L. Tong, N. K. Tse, X. P. Li, Y. Avihingsanon, P. Rianthavorn, T. Deekajorndej, K. Suphapeetiporn, V. Shotelersuk, S. K. Ying, S. K. Fung, W. M. Lai, C. M. Wong, I. O. Ng, M. M. Garcia-Barcelo, S. S. Cherny, P. K. Tam, P. C. Sham, S. Yang, D. Q. Ye, Y. Cui, X. J. Zhang, W. Yang and Y. L. Lau (2015). "Meta-analysis of two Chinese populations identifies an autoimmune disease risk allele in 22q11.21 as associated with systemic lupus erythematosus." Arthritis Res Ther 17: 67. (Co-first authorship)
25. Y. F. Wang, S. Lin, Q. Song, K. Li, H. Tao, J. Huang, X. Chen, S. Que and H. He (2014). "Genome-wide identification of heat shock proteins (Hsps) and Hsp interactors in rice: Hsp70s as a case study." BMC Genomics 15: 344.
26. Y. Yang, X. B. Lang, P. Zhang, R. Lv, Y. F. Wang and J. H. Chen (2014). "Remote ischemic preconditioning for prevention of acute kidney injury: a meta-analysis of randomized controlled trials." Am J Kidney Dis 64(4): 574-583.
27. Y. Zhang, J. Zhang, J. Yang, Y. F. Wang, L. Zhang, X. Zuo, L. Sun, H. F. Pan, N. Hirankarn, T. Wang, R. Chen, D. Ying, S. Zeng, J. J. Shen, T. L. Lee, C. S. Lau, T. M. Chan, A. M. Leung, C. C. Mok, S. N. Wong, K. W. Lee, M. H. Ho, P. P. Lee, B. H. Chung, C. Y. Chong, R. W. Wong, M. Y. Mok, W. H. Wong, K. L. Tong, N. K. Tse, X. P. Li, Y. Avihingsanon, P. Rianthavorn, T. Deekajorndej, K. Suphapeetiporn, V. Shotelersuk, S. K. Ying, S. K. Fung, W. M. Lai, C. M. Wong, I. O. Ng, M. M. Garcia-Barcelo, S. S. Cherny, P. K. Tam, P. C. Sham, S. Yang, D. Q. Ye, Y. Cui, X. J. Zhang, Y. L. Lau and W. Yang (2014). "Meta-analysis of GWAS on two Chinese populations followed by replication identifies novel genetic variants on the X chromosome associated with systemic lupus erythematosus." Human Molecular Genetics. Jan 1;24(1):274-84.
28. W. Yang, P. P. Lee, M. K. Thong, T. M. Ramanujam, A. Shanmugam, M. T. Koh, K. W. Chan, D. Ying, Y. F. Wang, J. J. Shen, J. Yang and Y. L. Lau (2014). "Compound heterozygous mutations in TTC7A cause familial multiple intestinal atresias and severe combined immunodeficiency." Clin Genet.
29. X. Chen, S. Lin, Q. Liu, J. Huang, W. Zhang, J. Lin, Y. F. Wang, Y. Ke and H. He (2014). "Expression and interaction of small heat shock proteins (sHsps) in rice in response to heat stress." Biochim Biophys Acta 1844(4): 818-828.
30. S. Que, K. Li, M. Chen, Y. F. Wang, Q. Yang, W. Zhang, B. Zhang, B. Xiong and H. He (2012). "PhosphoRice: a meta-predictor of rice-specific phosphorylation sites." Plant Methods 8: 5.
31. X. Chen, W. Zhang, B. Zhang, J. Zhou, Y. F. Wang, Q. Yang, Y. Ke and H. He (2011). "Phosphoproteins regulated by heat stress in rice leaves." Proteome Sci 9: 37.
32. S. Que, Y. F. Wang, P. Chen, Y. R. Tang, Z. Zhang and H. He (2010). "Evaluation of protein phosphorylation site predictors." Protein Pept Lett 17(1): 64-69. (Co-first authorship)