PhD (Washington University in St. Louis, USA)

Prof. Ye graduated from Shanghai Second Medical College in 1982, and obtained his PhD degree from Washington University in St. Louis in 1988. Since 1989, he started his independent research from assistant professor to full professor at The Scripps Research Institute and University of Illinois College of Medicine. His main research directions include G protein-coupled receptors and their signaling functions in innate immune cells, mechanisms of inflammation and pathological models, and anti-inflammatory drug targets. He has collaborated with Johnson & Johnson, Novartis and GSK, and obtained 2 U.S. patents and 2 Chinese patents as first inventor, and 2 other patents as co-inventor. Prof. Ye has published 230 SCI papers that have been cited for more than 20,000 times. He served as Chair Professor and Dean of School of Pharmacy at Shanghai Jiao Tong University (2010-2014) and Chair Professor at University of Macau (2015-2019). Prof. Ye joined The Chinese University of Hong Kong, Shenzhen in February 2019 to establish School of Life and Health Sciences. In 2020 he led the effort of establishing the CUHK(SZ) Futian Biomedical Innovation R&D Center. Prof. Ye was elected Excellent Teacher of Shenzhen in 2021, and received Outstanding Research Award of CUHK(SZ) in 2022. In recent years he has been on the lists of Clarivate Highly Cited Researcher (2018-2020, 2022), Stanford World's top 2% Scientist (2020-2023), and Elsevier’s Most Cited Chinese Researchers (2022). Among the academic services he provided are Associate Editor of The FASEB Journal, Associate Editor of Pharmacological Reviews, and Editorial Boards of Molecular Pharmacology and British Journal of Pharmacology. The Ye Lab is open for applications from interested postdoctoral fellows, PhD and master degree students, and undergraduate exchange students.

Selected Publications：

1. Wu MY, Ge YJ, Wang EJ, Liao QW, Ren ZY, Yu Y, Zhu G, Liu CP, Zhang MN, Su H, Shen HM, Chen Y, Wang L, Wang YT, Li M, Bian Z, Chai J, Ye RD, Lu JH. Enhancement of efferocytosis through biased FPR2 signaling attenuates intestinal inflammation. EMBO Molecular Medicine 2023 Dec 7;15(12):e17815. doi: 10.15252/emmm.202317815. Epub 2023 Nov 22. PMID: 37994307.

2. Liu Y, Liang S, Shi D, Zhang Y, Bai C, Ye RD. A predicted structure of NADPH Oxidase 1 identifies key components of ROS generation and strategies for inhibition. PLoS One. 2023 May 3;18(5):e0285206. doi: 10.1371/journal.pone.0285206. PMID: 37134122.

3. Wang J, Chen G, Liao Q, Lyu W, Liu A, Zhu L, Du Y, Ye RD. Cryo-EM structure of the human chemerin receptor 1-Gi protein complex bound to the C-terminal nonapeptide of chemerin. Proceedings of National Academy of Science U.S.A. 2023 Mar 14;120(11):e2214324120. doi: 10.1073/pnas.2214324120. Epub 2023 Mar 7. PMID: 36881626.

4. Chen G, Wang X, Liao Q, Ge Y, Jiao H, Chen Q, Liu Y, Lyu W, Zhu L, van Zundert GCP, Robertson MJ, Skiniotis G, Du Y, Hu H, Ye RD. Structural basis for recognition of N-formyl peptides as pathogen-associated molecular patterns. Nature Communications. 2022 Sep 5;13(1):5232. doi: 10.1038/s41467-022-32822-y. PMID: 36064945.

5. Wang J, Ye RD. Agonist concentration-dependent changes in FPR1 conformation lead to biased signaling for selective activation of phagocyte functions. Proceedings of National Academy of Science U.S.A. 2022 Aug 2;119(31):e2201249119. doi: 10.1073/pnas.2201249119. Epub 2022 Jul 25. PMID: 35878025.

6. Liao Q, Ye RD. Structural and conformational studies of biased agonism through formyl peptide receptors. American Journal of Physiology - Cellular Physiology. 2022 Apr 6. doi: 10.1152/ajpcell.00108.2022. Epub ahead of print. PMID: 35385323.

7. Belambri SA, Marzaioli V, Hurtado-Nedelec M, Pintard C, Liang S, Liu Y, Boussetta T, Gougerot-Pocidalo MA, Ye RD, Dang PM, El-Benna J. Impaired p47phox phosphorylation in neutrophils from patients with p67phox-deficient chronic granulomatous disease. Blood. 2022 Apr 21;139(16):2512-2522. PMID: 35108370.

8. Bai C, Wang J, Mondal D, Du Y, Ye RD, Warshel A. Exploring the Activation Process of the β2AR-Gs Complex. Journal of American Chemical Society. 2021 Jul 28;143(29):11044-11051. doi: 10.1021/jacs.1c03696. Epub 2021 Jul 13. PMID: 34255502.

9. Zhang S, Gong H, Ge Y, Ye RD. Biased allosteric modulation of formyl peptide receptor 2 leads to distinct receptor conformational states for pro- and anti-inflammatory signaling. Pharmacological Research. 2020 Aug 5;161:105117. doi: 10.1016/j.phrs.2020.105117. Epub ahead of print. PMID: 32768626.

10. Cheng N, Liang Y, Du X, Ye, RD. Serum amyloid A promotes LPS clearance andsuppresses LPS-induced inflammation and tissue injury. EMBO Reports 2018 Oct;19(10). pii: e45517;  doi: 10.15252/embr.201745517. PMID: 30126923.