DU, Juan
Assistant Professor
Ph.D. (The Chinese University of Hong Kong)
M.Sc (Anhui Medical University)
B.Sc. (Shool of Medicine, Jiamusi University)
1) Calcium signal and tumor extracellular vesicle secretion mechanism
2) Exosomes in the precision treatment of disease
3) Screening early diagnosis and treatment markers based on clinical big data and proteomics
4) Aggregation induced luminous(AIE) molecules in extracellular vesicle tracing and the application of the photothermal, photodynamic treatment of tumor.
Dr. Juan DU received her Bachelor Degree of Clinical Medicine from School of Medicine at Jiamusi University in 2000 and Master Degree of Physiology from Anhui Medical University in 2004. Afterwards Dr. Du went to the Health Science Center at the University of North Texas from 2005 to 2006 as a visiting scholar. Dr. Du earned her Ph.D. from the School of Biomedical Sciences at The Chinese University of Hong Kong in 2011. From 2004 to 2020, Dr. Du served as Professor in Physiology, Vice Dean in School of Basic Medical Science, Director of The National Simulation Experimental Center in Basic Medicine, in Anhui Medical University. In 2020, Dr. Du joined The Chinese University of Hong Kong, Shenzhen and contributed to the preparation of School of Medicine. Currently, she is an Assistant Professor and appointed as Assistant Dean (Education) in School of Medicine.
Dr. Du’s research mainly focus on calcium signal and cell function, mechanism of tumor exosome secretion, exosome and early diagnosis of tumor, targeted delivery of exosomes and so on. She has presided 4 projects of National Natural Science Foundation of China and 10 provincial scientific research projects. She has also published over 60 academic papers on SCI journals including JASN, Hypertension, etc. Dr. Du has granted High-level Professionals of Longgang Distrcit, Shenzhen. Dr. Du has also won a Third Prize of Science and Technology Achievement Award in Anhui Province. Additionally, she is committed to the medical education, teaching reform and the cultivation of students’ innovation ability. Dr. Du has presided over 8 teaching projects, including the Ministry of Education industry-university cooperative education project, provincial educational reform project and provincial MOOC demonstration project. Dr. Du has granted the title of Famous Teacher of Anhui province, won 3 provincial teaching achievement awards and published over 20 teaching research articles. She has participated as chief editor, deputy chief editor and editorial board member in editing 7 textbooks, including “Refined Physiology” ESP digital textbook, “Physiology”, “Basic Medicine Integrated Experiments” etc. She has also instructed the undergraduate students to obtain nearly 20 national and provincial awards, including the second place of the International Competition of Medical Physiology Knowledge and the champion of the domestic competition, the bronze prize of the National Competition and the champion of the Provincial Competition of Internet + University Students’ Innovation and Entrepreneurship Competition.
- Jialin Meng, Yonghao Chen, Xiaofan Lu, Qintao Ge, Feixiang Yang, Suwen Bai, Chaozhao Liang, Juan Du. Macrophages and monocytes mediated activation of oxidative phosphorylation implicated the prognosis and clinical therapeutic strategy of Wilms tumour. Comput Struct Biotechnol J. 2022 Jun 27;20:3399-3408.
- Suwen Bai, Yuan Wei, Rong Liu, Rruihuan Xu, Li Xiang, Juan Du. Role of tumour-derived exosomes in metastasis. Biomed Pharmacother. 2022 Jan 22;147:112657.
- Wenjun Zhang, Rong Liu, Yuhua Chen, Minghua Wang, Juan Du. Crosstalk between Oxidative Stress and Exosomes. Oxid Med Cell Longev. 2022 Aug 30;2022:3553617.
- PengFei Tian, MengMeng Sun, XianYu Hu, Juan Du*, Wei He*. TRPP2 ion channels: The roles in various subcellular locations. Biochimie. 2022 Oct;201:116-127.
- Jialin Meng, Qintao Ge, Jiawei Li, Xiaofan Lu, Yonghao Chen, Haitao Wang, Meng Zhang, Juan Du, Li Zhang, Zongyao Hao, Chaozhao Liang. Protective trend of anti-androgen therapy during the COVID-19 pandemic: A meta-analysis. J Infect. 2022 Jun;84(6):834-872.
- Suwen Bai, Zunyun Wang, Minghua Wang, Junai Li, Yuan Wei, Ruihuan Xu, Juan Du. Tumor-Derived Exosomes Modulate Primary Site Tumor Metastasis. Front Cell Dev Biol. 2022; 10: 752818.
- Huake Cao, Yuechen Wang, Ning Zhang, Siyuan Xia, Pengfei Tian, Li Lu, Juan Du*, Yinan Du*. Progress of CRISPR-Cas13 Mediated Live-Cell RNA Imaging and Detection of RNA-Protein Interactions. Front. Cell Dev. Biol. 09 March 2022
- Suwen Bai, Yuan Wei, Rong Liu, Ruihuan Xu, Li Xiang, Juan Du. Role of tumour-derived exosomes in metastasis. Biomed Pharmacother. 2022; 147: 112657.
- Suwen Bai, Wenxuan Hou, Yanheng Yao, Jialin Meng, Yuan Wei, Fangfang Hu, Xianyu Hu, Jing Wu, Ning Zhang, Ruihuan Xu, Faqing Tian, Benguo Wang, Hailan Liao, Yinan Du, Haoshu Fang, Wei He, Yehai Liu, Bing Shen, Juan Du. Exocyst controls exosome biogenesis via Rab11a.. Molecular Therapy-Nucleic Acids. Mol Ther Nucleic Acids. 2021; 27: 535-546.
- Xianyu Hu, Zhenglin Wang, Qing Wang, Ke Chen, Qijun Han, Suwen Bai, Juan Du, Wei Chen. Molecular classification reveals the diverse genetic features and prognosis of gastric cancer: a multi-omics consensus ensemble clustering. Biomedicine & Pharmacotherapy. 2021; 144: 112222.
- Yuan Wei, Suwen Bai, Yanheng Yao, Wenxuan Hou, Fangfang Hu, Yinan Du, Wei He, Bing Shen, Juan Du. Orai-VE-cadherin signaling complex regulates high-glucose exposure–induced increased permeability of mouse aortic endothelial cells. BMJ Open Diabetes Research&Care. 2021; 9(1): e002085.
- Xianyu Hu, Suwen Bai, Lingyi Li, Pengfei Tian, Sun Wang, Ning Zhang, Bing Shen, Juan Du*, Shengxiu Liu*. MiR-200c-3p increased HDMEC proliferation through the Notch signaling pathway. Experimental Biology and Medicine. 2021; 246(8):897-905.
- Suwen Bai, Yuan Wei, Wenxuan Hou, YanHeng Yao, Junwei Zhu, Xianyu Hu, Wei Chen, Yinan Du, Wei He, Bing Shen, Juan Du. Orai- IGFBP3 Signaling Complex Regulates High-Glucose Exposure-Induced Increased Proliferation, Permeability, and Migration of Human Coronary Artery Endothelial Cells. BMJ Open Diabetes Research&Care. 2020, 8(1): e001400.
- Ning Zhang, Xianyu Hu, Yinan Du, Juan Du. The role of miRNAs in colorectal cancer progression and chemoradiotherapy. Biomedicine & Pharmacotherapy. 2020, 134, 111099
- Yuan-Yuan Huang, Jing Li, He-Rui Zhang, Su-Wen Bai, Hui-Yun Yang, Bing Shen, Juan Du*, Xian-Ming Xia* . The Effect of Transient Receptor Potential Vanilloid 4 on the Intestinal Epithelial Barrier and Human Colonic Cells was Affected by Tyrosine-Phosphorylated Claudin-7. Biomedecine & pharmacotherapie. 2020, 122:109697.
- Shuai Xu, Jiarong Wang, Yuan Wei, Hongxin Zhao, Tongxiang Tao, Hui Wang, Zhen Wang, Juan Du, Hongzhi Wang, Junchao Qian, Kun Ma, Junfeng Wang. In Situ One-Pot Synthesis of Fe2O3@BSA Core-Shell Nanoparticles as Enhanced T1‑Weighted Magnetic Resonance Imagine Contrast Agents. ACS Applied Materials & Interfaces. 2020,12(51):56701-56711
- Suwen Bai, Qianqian Yin, Tao Dong, Fang Dai, Ying Qin, Li Ye, Juan Du, Qiu Zhang, Hongbo Chen, Bing Shen. Endothelial Progenitor Cell-Derived Exosomes Ameliorate Endothelial Dysfunction in a Mouse Model of Diabetes. Biomedicine & Pharmacotherapy. 2020. 110756.
- Zhang Hanqing, Lv Yayao, Du Juan, Shao Wei, Jiao Fenglong, Xia Chaoshuang, Gao Fangyuan, Yu Qian, Liu Yuanyuan, Zhang Wangjun, Zhang Yangjun, Qin Weijie, Qian Xiaohong. A GSH Functionalized Magnetic Ultra-thin 2D-MoS. Analytica chimica acta. 2020, 1098: 181-189.
- Guo Jizheng, Li Jie, Xia Lin, Wang Yang, Zhu Jinhang, Du Juan, Lu Yungang, Liu Guodong, Yao Xiaoqiang, Shen Bing. Transient Receptor Potential Canonical 5-Scramblase Signaling Complex Mediates Neuronal Phosphatidylserine Externalization and Apoptosis. Cells. 2020, 9(3). pii: E547.
- Jie Zhang, Yuan Wei, Suwen Bai, Shenggang Ding, Huiwen Gao, Sheng Yin, Shuo Chen, Jinsen Lu, Haoran Wang, Yonggang Shen, Bing Shen, Juan Du. TRPV4 Complexes With the Na+/Ca2+ Exchanger and IP3 Receptor 1 to Regulate Local Intracellular Calcium and Tracheal Tension in Mice. Frontiers in Physiology. 2019, 10: 1471.
- Dacheng Sang, Suwen Bai, Sheng Yin, Sen Jiang, Li Ye, Wenxuan Hou, Yanheng Yao, Haoran Wang, Yonggang Shen, Bing Shen, Juan Du. Role of TRPP2 in Mouse Airway Smooth Muscle Tension and Respiration. Am J Physiol Lung Cell Mol Physiol. 2019, 317(4): L466-L474.
- Jing-Si Duan, Shuo Chen, Xiao-Qing Sun, Juan Du*, Zhi-Wu Chen*. Urotensin-#Receptor Antagonist SB-706375 Protected Isolated Rat Heart from Ischaemia-Reperfusion Injury by Attenuating Myocardial Necrosis via RhoA/ROCK/RIP3 Signalling Pathway. Inflammopharmacology. 2019, 27(6): 1309-1318.
- Chuyan Wang, Wenhui Cheng, Suwen Bai, Li Ye, Juan Du, Mingkui Zhong, Jian Liu, Ren Zhao, Bing Shen. White Mulberry Fruit Polysaccharides Enhance Endothelial Nitric Oxide Production to Relax Arteries in Vitro and Reduce Blood Pressure in Vivo. Biomedicine&pharmacotherapy. 2019, 116: 109022.
- Wan Jiang, Li Ye, Yuexin Yang, Pingping Wang, Wen Pan, Juan Du, Bing Shen, Kai Wang. TRPP2 Associates with STIM1 to Regulate Cerebral Vasoconstriction and Enhance High Salt Intake-Induced Hypertensive Cerebrovascular Spasm. Hypertension research. 2019, 42(12): 1894-1904
- Junwei Zhu, Kaile Wu, Zhangying Lin, Suwen Bai, Jing Wu, Peikun Li, Haowei Xue, Juan Du, Bing Shen, Huiyin Wang, Yehai Liu. Identification of susceptibility Gene Mutations Associated with the Pathogenesis of Familial Nonmedullary Thyroid Cancer. Molecular genetics & genomic medicine. 2019; 7(12): e1015.
- Chunhui Wang, Lei Chen, Yuanyuan Huang, Kun Li, Anqi Jinye, Taotao Fan, Ren Zhao, Xianming Xia, Bing Shen, Juan Du, Yehai Liu. Exosome-Delivered TRPP2 siRNA Inhibits the Epithelial-Mesenchymal Transition of FaDu Cells. Oncology Letters. 2019, 17(2):1953-1961.
- Wan Jiang, Wei Hu, Li Ye, Yanghua Tian, Ren Zhao, Juan Du, Bing Shen, Kai Wang. Contribution of Apelin-17 to Collateral Circulation Following Cerebral Ischemic. Stroke. 2019, 10(3): 298-307.
- YuanYuan Huang, ZhenKai Wang, Jing Li, Su-Wen Bai, Bing Shen, Juan Du, XianMing Xia, FangYu Wang. The Effect of Serine Phosphorylated Claudin-7 on the Epithelial Barrier and the Modulation by Transient Receptor Potential Vanilloid 4 in Human Colonic Cells. Biomed Pharmacother. 2018,108: 540-546.
- Shengang Ding, Jie Zhang, Sheng Yin, Jingsen Lu, Min Hu, Juan Du, Junhao Huang, Bing Shen. Inflammatory Cytokines Tumour Necrosis Factor-α and Interleukin-8 Enhance Airway Smooth Muscle Contraction by Increasing L-type Ca2+ Channel Expression. Clinical and Experimental Pharmacology & Physiology. 2019, 46(1):56-64.
- Jinsen Lu, Lele Wu, Xiaoke Wang, Jinhang Zhu, Juan Du, Bing Shen. Detection of Mitochondria Membrane Potential to Study CLIC4 Knockdown-Induced HN4 Cell Apoptosis In Vitro. Journal of Visualized Experiments. 2018, l 17;(137).
- Dezhi Yu, Yang Fang, Menglan Xu, Jinhang Zhu, Kun Li, Kaile Wu, Chuyan Wang, Bing Shen, Juan Du*, Yehai Liu. Tumor Necrosis Factor a Promotes Hep-2 cell Proliferation via Toll-Like Receptor 4 and NF-kB Signaling Pathways. Int J Clin Exp Pathol. 2017; 10(12):11666-11672.
- Jing Wu,Jizheng Guo,Yunyun Yang,Feifei Jiang,Shuo Chen,Kaile Wu,Bing Shen,Yehai Liu,Juan Du. Tumor Necrosis Factor ɑ accelerates Hep-2 Cells Proliferation by Suppressing TRPP2 Expression. Sci China Life Sci. 2017, 60(11): 1251-1259.
- Chunrong Qu, Mingmin Ding, Yingmin Zhu, Yungang Lu, Juan Du, Melissa Miller, Jinbin Tian, Jinmei Zhu, Jian Xu, Meng Wen, Aga Er-Bu, Jule Wang, Yuling Xiao, Meng Wu, Owen B McManus, Min Li, Jilin Wu, Huai-Rong Luo, Zhengyu Cao, Bing Shen, Hongbo Wang, Michael X Zhu, Xuechuan Hong. Pyrazolopyrimidines as Potent Stimulators for Transient Receptor Potential Canonical 3/6/7 Channels. Journal of Medicinal Chemistry. 2017, 60(11): 4680-4692.
- Juan Du, Xia Wang, Jie Li, Jizheng Guo, Limei Liu, Dejun Yan, Yunyun Yang, Zhongwen Li, Jinhang Zhu,Bing Shen. Increasing TRPV4 Expression Restores Flow-Induced Dilation Impaired in Mesenteric Arteries with Aging. Sci Rep. 2016, 6: 22780.
- Juan Du, Jie Fu, Xian-ming Xia,Bing Shen. The Functions of TRPP2 in the Vascular System. Acta Pharmacol Sin. 2016; 37(1):13-18.
- Xingguo Zhong ,Jie Fu,Kai Song,Nairui Xue,Renhua Gong,Dengqun Sun,Huilai Luo,Wenzhu He,Xiang Pan,Bing Shen,Juan Du. The Role of TRPP2 in Agonist-Induced Gallbladder Smooth Muscle Contraction. Sci China Life Sci. 2016, 59(4):409-416.
- Kai Song, Xingguo Zhong, Xianming Xia, Junhao Huang, Yifei Fan, Renxiang Yuan, Nairui Xue, Juan Du, Wenxiu Han, Aman Xu, Bing Shen. Orai1 Forms a Signal Complex with SK3 Channel in Gallbladder Smooth Muscle. Biochem Biophys Res Commun. 2015, 466(3): 456-462.
- Bing Shen, Jie Fu, Jizheng Guo, Jie Zhang, Xia Wang, Xiang Pan, Meihua Chen, Yifan Zhou, Min Zhu, Juan Du. Role of Na+-K+-2Cl- Cotransporter 1 in Phenylephrine-Induced Rhythmic Contraction in the Mouse Aorta: Regulation of Na+-K+-2Cl- Cotransporter 1 by Ca2+ Sparks and KCa Channels. Cell Physiol Biochem. 2015, 37(2): 747-758.
- Yong Yang, Jinhang Zhu, Xia Wang, Nairui Xue, Juan Du, Xiangling Meng, Bing Shen. Contrasting Patterns of Agonist-Induced Store-Operated Ca2+ Entry and Vasoconstriction in Mesenteric Arteries and Aortae with Aging. J Cardiovasc Pharmacol. 2015, 65(6): 571-578.
- Ren Zhao, Muyao Zhou,JieLi, Xia Wang, Kunli Su, Juncheng Hu, Yong Ye, Jinhang Zhu, Gongliang Zhang, Kai Wang, Juan Du, Liecheng Wang,Bing Shen. Increased TRPP2 Expression in Vascular Smooth Muscle Cells from High-Salt Intake Hypertensive Rats: The Crucial Role in Vascular Dysfunction. Mol Nutr Food Res. 2015, 59(2): 365-372.
- Jing Li, Yong-Xiang Li, Mei-Hua Chen, Jie Li, Juan Du, Bing Shen, Xian-Ming Xia. Changes in the Phosphorylation of Claudins During the Course of Experimental Colitis. Int J Clin Exp Pathol. 2015, 8(10): 12225-12233.
- Juan Du, Xin Ma, Bing Shen, Yu Huang, Lutz Birnbaumer, Xiaoqiang Yao. TRPV4, TRPC1, and TRPP2 Assemble to Form a Flow-Sensitive Heteromeric Channel. FASEB J. 2014, 28(11):4677-4685.
- Zhiqiang Yu, Jie Li, Jinhang Zhu, Min Zhu, Feifei Jiang, Jin Zhang, Zhongwen Li, Mingkui Zhong, Justin Boy Kaye, Juan Du*, Bing Shen*. A Synthetic Transmembrane Segment Derived from TRPV4 Channel Self-Assembles into Potassium-like Channels to Regulate Vascular Smooth Muscle Cell Membrane Potential. J. Mater. Chem. B, 2014, 2, 3809-3818.
- Bing Shen, Jinhang Zhu, Jin Zhang, Feifei Jiang, Zhaoyi Wang,Yang Zhang, Jie Li, Dake Huang, Daoping Ke, Rong Ma, Juan Du. Attenuated Mesangial Cell Proliferation Related to Store-Operated Ca2+ entry in Aged Rat: the Role of STIM 1 and Orai1. Age . 2013, 35(6):2193-2020.
- Xin Ma#, Juan Du#, Peng Zhang, Jianxin Deng, Jie Liu, Francis Fu-Yuen Lam, Ronald A Li, Yu Huang, Jian Jin, Xiaoqiang Yao. Functional Role of TRPV4-KCa2.3 Signaling in Vascular Endothelial Cells in Normal and Streptozotocin-Induced Diabetic Rats. Hypertension. 2013, 62(1): 134-139.
- Juan Du, Wei-Yan Wong, Lei Sun, Yu Huang, Xiaoqiang Yao. Protein Kinase G Inhibits Flow-Induced Ca2+ Entry into Collecting Duct Cells. J Am Soc Nephro, 2012, 23(7): 1172-1180.
- Bing Shen, Hiu-Yee Kwan, Xin Ma, Ching-On Wong, Juan Du, Yu Huang, Xiaoqiang Yao. cAMP Activates TRPC6 Channels via the Phosphatidylinositol 3-Kinase (PI3K)-Protein Kinase B (PKB)-Mitogen-Activated Protein Kinase Kinase (MEK)-ERK1/2 Signaling Pathway. J Biol Chem. 2011, 286(22): 19439-19445.
- Yukki Leung, Juan Du, Yu Huang, Xiaoqiang Yao. Cyclic Nucleotide-Gated Channels Contribute to Thromboxane A2-induced Contraction of Rat Small Mesenteric Arteries. Plos one.2010, 5(6): e11098.
- Juan Du, Min Ding, Sherry Sours-Brothers, Sarabeth Graham, Rong Ma. Mediation of Angiotensin II Ca2+ Signaling by Polycystin 2 in Glomerular Mesangial Cells. Am J Physiol Renal Physiol, 2008, 294(4): F909-918.
- Juan Du, Sherry Sours-Brother, Coleman Rashadd, Min Ding, Sarabeth Graham, Dehu Kong DH, Rong Ma. Canonical Transient Receptor Potential 1 Channel is Involved in Contractile Function of Glomerular Mesangial Cells. J Am Soc Nephrol, 2007, 18(5): 1437-1445.
- Rong Ma, Juan Du, Sherry Sours, Min Ding. Store-operated Ca2+ Channel in Renal Microcirculation and Glomeruli. Exp Biol Med. 2006, 231(2): 145-153.
- Sherry Sours, Juan Du, ShaoYou Chu, Min Ding, XinJie Zhou, Rong Ma. Expression of Canonical Transient Receptor Potential (TRPC) Proteins in Human Glomerular Mesangial Cells. Am J Physiol Renal Physiol. 2006, 290(6): F1507-1515.