Ph.D. (University of Southern California)

MSc (Tsinghua University)

BSc (Peking University)

Prof. Yun Bai works at School of MEDICINE, CUHK-Shenzhen as an Associate Professor (Teaching). Prof. Yun Bai got her Bachelor's degree in Pharmacy from Peking University Health Science Center, Master's degree in Biochemistry and Molecular Biology from Tsinghua University, and Ph.D. degree in Pharmaceutical Sciences from University of Southern California. Before joining CUHK-Shenzhen, Dr. Bai worked as an Associate Professor at the Department of Pharmaceutical Sciences of Philadelphia College of Osteopathic Medicine.

Prof. Bai has 24 publications so far, including some high impact scientific journals such as PNAS and Pharmaceutical Research. She has one US patent. Her research areas include protein/peptide drug oral and transdermal delivery, recombinant fusion protein development, mechanism study of drug adverse effect using traditional pharmacology method and pharmacogenomic tools.

1. Francis CE, Bai Y (2018) Differential Expression of Cyclosporine A-Induced Calcineurin Isoform-Specific Matrix Metalloproteinase 9 (MMP-9) in Renal Fibroblasts. Biochem Biophys Res Commun. 2018 Sep 18;503(4):2549-2554. doi: 10.1016/j.bbrc.2018.07.014. Epub 2018 Jul PMID: 30007437
2. Lu J, Lu Y, Ding Y, Xiao Q, Liu L, Cai Q, Kong Y, Bai Y* and Yu*. (2018) Detecting Differential Consistency Genes and Network Modules. International Symposium on Bioinformatics Research and Applications (ISBRA) (Accepted) (* Joint correspondence authors)
3. Gooch JL, King C, Francis CE, Garcia PS, Bai Y.(2017) Cyclosporine A alters expression of renal microRNAs: New insights into calcineurin inhibitor nephrotoxicity. PLoS One. 2017 Apr 17;12 (4):e0175242
4. Yan Y*, Qiu S*, Jin Z, Gong S, Bai Y#, Lu J#, Yu T# (2017) Detecting subnetwork-level dynamic correlations. Bioinformatics. (2017) Jan 15;33(2):256-265. doi: 10.1093/bioinformatics/btw616. Epub 2016 Sep 25.PMID:27667792(*Joint first authors, # Joint correspondence authors)
5. Peng H, Ma J, Bai Y, Lu J, Yu T. (2015) MeDiA: Mean Distance Association and Its Applications in Nonlinear Gene Set Analysis. PLoS One. 2015 Apr 27;10(4) e0124620
6. Yu T, Bai Y (2014) Network-based modular latent structure analysis. BMC Bioinformatics. 2014;15 Suppl 13:S6.
7. Yang R, Bai Y, Qin Z, Yu T (2014) EgoNet: identification of human disease ego-network modules, BMC Genomics Apr 28;15:314.
8. Bai Y, Kim Y, Banga, Aj (2014) Transdermal delivery of proteins using a combination of iontophoresis and microporation. Therapeutic Delivery May; 5(5):525-36
9. Sachdeva V, Bai Y, Kydonieus A, Banga AK. (2013) Formulation and optimization of desogestrel transdermal contraceptive patch using crystallization studies. Int J Pharm. 441(1-2):9-18.
10. Yu T, Bai Y. (2013) Analyzing LC/MS Metabolic Profiling Data in the Context of Existing Metabolic Networks. Current Metabolomics. 1(1): 84-91.
11. Vemulapalli V, Bai Y, Kalluri H, Herwadkar A, Kim H, Davis SP, Friden PM, Banga AK. (2013) In vivo iontophoretic delivery of salmon calcitonin across microporated skin. J Pharm Sci. 101(8):2861-9
12. Yu T^#, Bai Y^#. (2011) Improving gene expression data interpretation by finding latent factors that co-regulate gene modules with clinical factors. BMC Genomics. 12:563. (^# joint correspondence author)
13. Yu T^#, Bai Y^#. (2011) Capturing Changes in Gene Expression Dynamics by Gene Set Differential Coordination Analysis. Genomics. 98(6):469-77. (^# joint correspondence author)
14. Chen X, Bai Y, Zaro J, Shen WC. (2010) Design of an in vivo cleavable disulfide linker in recombinant fusion proteins. Biotechniques. 49(1): 513-8.
15. Bai Y, Shen WC. (2006) Improving the oral efficacy of recombinant granulocyte colony-stimulating factor and transferrin fusion protein by spacer optimization. Pharm Res. 23(9):2116-21.
16. Bai Y, Ann DK, Shen WC. (2005) Recombinant granulocyte colony-stimulating factor-transferrin fusion protein as an oral myelopoietic agent. Proc Natl Acad Sci U S A. 102(20):7292-6.
17. Widera A, Bai Y, Shen WC. (2004) The transepithelial transport of a G-CSF-transferrin conjugate in Caco-2 cells and its myelopoietic effect in BDF1 mice. Pharm Res. 21(2):278-84.
18. Bai Y, Zhao Y, Yu T, Dierich MP, Chen YH. (2000) Antibodies to HIV-1 gp41 recognize synthetic peptides of human IFN-alpha and IFN-beta.  Int Arch Allergy Immunol. 121(2): 170-2.
19. Yu T, Bai Y, Dierich MP, Chen YH. (2000) Induction of high levels of epitope-specific antibodies by epitope/peptide candidate vaccines against human immunodeficiency virus type-1 (HIV-1). Microbiol Immunol. 44(2): 105-10.
20. Yu T, Xiao Y, Bai Y, Ru Q, Luo G, Dierich MP, Chen Y. (2000) Human interferon-beta inhibits binding of HIV-1 gp41 to lymphocyte and monocyte cells and binds the potential receptor protein P50 for HIV-1 gp41. Immunol Lett. 73(1):19-22.
21. Chen YH, Bai Y, Yu T, Dierich MP. (1999) Modulation of major histocompatibility complex antigen expression by human immunodeficiency virus-2 gp36. Immunol Lett. 68(2-3): 415-7.
22. Chen YH, Yu T, Bai Y, Dierich MP. (1999) Immunogenicity of the GPGRAFY epitope on synthetic peptides. Immunol Lett. 69(3): 353-4.
23. Chen YH, Yu T, Bai Y, Zhao N. (1999) Two proteins share immunological epitopes on the tumor-associated antigen 17-1A. Cancer Lett. 144(1): 101-5.
24. Bai Y, Yu T, Zhao Y, Xiao Y, Yang Y, Chen YH. (1999) A novel putative tumor associated antigen. Tsinghua Sci. & Tech. 4(3): 1568-9.