ZHENG, Jian

Adjunct Assistant Professor

Education Background

Doctor of Medicine (Sun Yat-sen University)

Bachelor of Clinical Medicine (Gannan Medical University)

Research Field
Focusing on ultrasonic diagnosis and interventional treatment of abdominal and superficial organs, he has in-depth research on new ultrasound technologies such as contrast ultrasound, ultrasound elastic imaging, and ultrasound minimally invasive intervention.
Email
lgsyzj@163.com
Biography

Professor Zheng Jian, MD, Sun Yat-sen University, Director of Ultrasound Medical Center, Longgang District People's Hospital Group, Shenzhen, doctoral/master supervisor, postdoctoral supervisor, visiting scholar of Thomas Jefferson University, USA; Responsible for general medicine, teaching, scientific research, etc. Focusing on ultrasonic diagnosis and interventional treatment of abdominal and superficial organs, he has in-depth research on new ultrasound technologies such as contrast ultrasound, ultrasound elastic imaging, and ultrasound minimally invasive intervention. He has published 61 papers, including 24 SCI papers; The first author/corresponding author of 26 papers, the highest impact factor 19.7 points; Two of the first author papers were published in the professional TOP journal RADIOLOGY (IF: 19.7). In the past three years, he has presided over the Guangdong Natural Science Foundation project, Shenzhen Science and Technology Innovation Commission Fund, Shenzhen Municipal Health and Family Planning Commission and other topics, and participated in a number of national natural science foundation projects; He has won the National Scholarship for doctoral students, the first prize of the Ultrasound Academic Annual Meeting of the Guangdong Medical Association, the second prize of the English Forum of the Chinese Medical Association Ultrasound Branch, the Excellent Paper award of the Chinese Ultrasound Physicians Academic Conference, and the Excellent Paper Award of the Ultrasound Branch of the Chinese Medical Imaging Technology Society.

Academic Publications

Selected Publications

  1. Liang X, Chen W, Wang C, Jiang K, Zhu J, Lu R, Lin Z, Cao Z, Zheng J（通讯作者）. A mesoporous theranostic platform for ultrasound and photoacoustic dual imaging-guided photothermal and enhanced starvation therapy for cancer. Acta Biomater. 2024 Jul 15;183:264-277.
  2. Du L, Deng H, Wu X, Liu F, Yin T, Zheng J（通讯作者）. Relationship Between Spleen Pathologic Changes and Spleen Stiffness in Portal Hypertension Rat Model. Ultrasound Med Biol. 2024 Feb;50(2):216-223. 
  3. Zheng J（第一作者）,Wu ML,Wang QJ, Gu RZ,Yao XH,Chen YS, Huang J,Long LX,  ZhengRQ. Liver and Spleen Stiffness Measurements by Sound Touch Elastography and Sound Touch Quantification. Advanced Ultrasound in Diagnosis and Therapy, 2020,4(4): 315-321.
  4. Zeng J, Zheng J（并列第一作者）, Jin JY, Mao YJ, Guo HY, Lu MD, Zheng HR, Zheng RQ. Shear wave elastography for liver fibrosis in chronic hepatitis B: Adapting the cut-offs to alanine aminotransferase levels improves accuracy. Eur Radiol. 2019 Feb;29(2):857-865. 
  5. Gao Y, Zheng J（并列第一作者）, Liang P, Tong M, Wang J, Wu C, He X, Liu C, Zhang S, Huang L, Jiang T, Cheng C, Meng F, Mu X, Lu Y, Li Y, Ai H, Qiao X, Xie XY, Wang W, Yin LP, Wu YY, Zheng R. Liver Fibrosis with Two-dimensional US Shear-Wave Elastography in Participants with Chronic Hepatitis B: A Prospective Multicenter Study. Radiology. 2018 Nov;289(2):407-415. 
  6. Zheng J（第一作者）, Guo H, Zeng J, Huang Z, Zheng B, Ren J, Xu E, Li K, Zheng R. Two-dimensional shear-wave elastography and conventional US: the optimal evaluation of liver fibrosis and cirrhosis. Radiology. 2015 Apr;275(1):290-300. 
  7. Liu J, Zhou X, Lin H, Lu X, Zheng J, Xu E, Jiang D, Zhang H, Yang X, Zhong J, Hu X, Huang Y, Zhang Y, Liang J, Liu Q, Zhong M, Chen Y, Yan H, Deng H, Zheng R, Ni D, Ren J. Deep learning based on carotid transverse B-mode scan videos for the diagnosis of carotid plaque: a prospective multicenter study. EurRadiol. 2023 May;33(5):3478-3487. 
  8. Wu M, Wang Q, Zhang M, Cao J, Chen Y, Zheng J, Luo L, Su M, Lin X, Kuang X, Zhang X. Does Combing O-RADS US and CA-125 Improve Diagnostic Accuracy in Assessing Adnexal Malignancy Risk in Women with Different Menopausal Status? J Ultrasound Med. 2022 Jul 26. 
  9. Wang J, Wu M, Linghu R, Chang J, Wu M, Feng C, Ren X, Liu C, Lin J, Song T, Gu J, Zhang Y, Fang Y, Ma S, Hu P, Wu L, Han X, Chen K, Shi Q, Zhang R, Zhou Q, Du R, Gao Y, Jing X, Yang S, Zhou C, Zheng J, Liang P, Zheng RQ. Usefulness of New Shear Wave Elastography Technique for Noninvasive Assessment of Liver Fibrosis in Patients with Chronic Hepatitis B: A Prospective Multicenter Study. Ultraschall Med. 2022 Apr;43(2):e1-e10. English. 
  10. Wu M, Wu L, Jin J, Wang J, Li S, Zeng J, Guo H, Zheng J, Chen S, Zheng R. Liver Stiffness Measured with Two-dimensional Shear-Wave Elastography Is Predictive of Liver-related Events in Patients with Chronic Liver Disease Due to Hepatis B Viral Infection. Radiology. 2020 May;295(2):353-360. 
  11. Guo H, Liao M, Jin J, Zeng J, Li S, Schroeder DR, Zheng J, Zheng R, Chen S. How intrahepatic cholestasis affects liver stiffness in patients with chronic hepatitis B: a study of 1197 patients with liver biopsy. Eur Radiol. 2020 Feb;30(2):1096-1104.
  12. Wang K, Lu X, Zhou H, Gao Y, Zheng J, Tong M, Wu C, Liu C, Huang L, Jiang T, Meng F, Lu Y, Ai H, Xie XY, Yin LP, Liang P, Tian J, Zheng R. Deep learning Radiomics of shear wave elastography significantly improved diagnostic performance for assessing liver fibrosis in chronic hepatitis B: a prospective multicentre study. Gut. 2019 Apr;68(4):729-741. 
  13. Jin JY, Zheng YB, Zheng J, Liu J, Mao YJ, Chen SG, Gao ZL, Zheng RQ. 2D shear wave elastography combined with MELD improved prognostic accuracy in patients with acute-on-chronic hepatitis B liver failure. Eur Radiol. 2018 Oct;28(10):4465-4474.
  14. Zeng J, Huang Z, Jin J, Zheng J, Wu T, Zheng R. Diagnostic Accuracy of 2-D Shear Wave Elastography for the Non-Invasive Staging of Liver Fibrosis in Patients with Elevated Alanine Aminotransferase Levels. Ultrasound Med Biol. 2018;44:85–93. 
  15. Herrmann E, de Lédinghen V, Cassinotto C, Chu WC, Leung VY, Ferraioli G, Filice C, Castera L, Vilgrain V, Ronot M, Dumortier J, Guibal A, Pol S, Trebicka J, Jansen C, Strassburg C, Zheng R, Zheng J, Francque S, Vanwolleghem T, Vonghia L, Manesis EK, Zoumpoulis P, Sporea I, Thiele M, Krag A, Cohen-Bacrie C, Criton A, Gay J, Deffieux T, Friedrich-Rust M. Assessment of biopsy-proven liver fibrosis by two-dimensional shear wave elastography: An individual patient data-based meta-analysis. Hepatology. 2018 Jan;67(1):260-272. 
  16. Zeng J, Zheng J, Huang Z, Chen S, Liu J, Wu T, Zheng R, Lu M. Comparison of 2-D Shear Wave Elastography and Transient Elastography for Assessing Liver Fibrosis in Chronic Hepatitis B. Ultrasound Med Biol. 2017 Aug;43(8):1563-1570. 
  17. Zeng J, Huang ZP, Zheng J, Wu T, Zheng RQ. Non-invasive assessment of liver fibrosis using two-dimensional shear wave elastography in patients with autoimmune liver diseases. World J Gastroenterol. 2017;23:4839–4846. 
  18. Wu T, Wang P, Zhang T, Zheng J, Li S, Zeng J, Kudo M, Zheng R. Comparison of Two-Dimensional Shear Wave Elastography and Real-Time Tissue Elastography for Assessing Liver Fibrosis in Chronic Hepatitis B. Dig Dis. Karger Publishers. 2016;34:640–649. 
  19. Wang P, Yin T, Li J, Zheng B, Wang X, Wang Y, Zheng J, Zheng R, Shuai X. Ultrasound-responsive microbubbles for sonography-guided siRNA delivery. Nanomedicine. Elsevier. 2016;12:1139–1149. 
  20. Wang CZ, Zheng J, Huang ZP, Xiao Y, Song D, Zeng J, Zheng HR, Zheng RQ. Influence of measurement depth on the stiffness assessment of healthy liver with real-time shear wave elastography. Ultrasound Med Biol. Elsevier. 2014;40:461–469.
  21. Huang Z, Zheng J, Zeng J, Wang X, Wu T, Zheng R. Normal liver stiffness in healthy adults assessed by real-time shear wave elastography and factors that influence this method. Ultrasound Med Biol. 2014;40:2549–2555.
  22. Zeng J, Liu GJ, Huang ZP, Zheng J, Wu T, Zheng RQ, Lu MD. Diagnostic accuracy of two-dimensional shear wave elastography for the non-invasive staging of hepatic fibrosis in chronic hepatitis B: a cohort study with internal validation. Eur Radiol. 2014;24:2572–2581.
  23. Li H, Wang J, Wang P, Zheng J, Song F, Yin T, Zhou G, Zheng R, Zhang C. Phase-transition contrast nanocapsules triggered by low-intensity ultrasound. Chem Commun(Camb). 2014;50:15163–15166.
  24. Huang Z-P, Zhang X-L, Zeng J, Zheng J, Wang P, Zheng R-Q. Study of detection times for liver stiffness evaluation by shear wave elastography. World J Gastroenterol. 2014;20:9578–9584.
  25. 吴晓婷, 郑剑（通讯作者）. 甲状腺结节超声恶性危险分层中国指南(C-TIRADS)临床应用进展[J/OL]. 中华超声影像学杂志, 2023, 32(11): 1002-1008.
  26. 黄伟斌,张又红,郑剑（通讯作者）.2型糖尿病患者股总动脉剪切力与冠脉粥样硬化程度的相关性分析[J].医药前沿,2023,13(2):111-114.
  27. 杜凌玥,郑剑（通讯作者）,罗麟,尤美霞,王理,熊培环.下腔静脉按压同步改良Valsalva动作对卵圆孔未闭的应用价值[J].中华超声影像学杂志,2022,31(08):712-716.
  28. 张又红,伍伟科, 郑剑（通讯作者）.经食管实时三维超声心动图评估非瓣膜性房颤患者左心耳功能的价值观察[J].广州医科大学学报,2022,50(01):46-50.
  29. 王青娟,梁茜,郑剑（通讯作者）,康斯亮,黄丽玲.超声造影联合卵巢-附件超声报告和数据风险分层系统的临床应用价值[J].中华超声影像学杂志,2022,31(03):220-225.
  30. 朱利容,彭翔,杜凌玥,姚小虹,古日珍,郑剑（通讯作者）.ACR-TIRADS与C-TIRADS分级在甲状腺良恶性结节鉴别诊断中的价值比较[J].影像研究与医学应用,2022,6(21):39-41,45.DOI:10.3969/j.issn.2096-3807.2022.21.013.
  31. 彭翔,古日珍,郑剑（通讯作者）.子宫内膜合并卵巢原发性双癌1例[J].中国医学影像技术,2021,37(3):379.
  32. 郑剑（第一作者）,吴曼丽,王青娟,王进芬,张敏,彭翔,姚小虹,郑荣琴.声触诊弹性成像与二维剪切波弹性成像检测肝脏硬度的比较[J].中山大学学报(医学科学版),2020,41(04):644-648.
  33. 郑剑（第一作者）,张敏,王青娟,黄晶,陈远森,彭翔,邹思源,黄启平,郑荣琴.超声造影鉴别膀胱良恶性占位的诊断价值初探[J].中华腔镜泌尿外科杂志(电子版),2020,14(03):181-184.
  34. 王青娟,郑剑（通讯作者）,古日珍,姚小虹,康斯亮,龙乐香,周丹,王小立,郑荣琴.声触诊弹性测量与声脉冲辐射力成像检测肝脾硬度的比较研究[J].中华普通外科学文献(电子版),2019,13(05):398-401.
  35. 郑剑（第一作者）,吴曼丽,张敏,裴少华,王青娟,黄晶,朱利容,王小立,郑荣琴.声触诊弹性成像和声触诊弹性测量检测肝脾硬度重复性研究[J].中华肝脏外科手术学电子杂志,2019,8(04):366-369.
  36. 郑剑（第一作者）,吴曼丽,钟梅,邹思源,古日珍,龙乐香,康斯亮,曾婕,郑荣琴.声触诊弹性成像和声触诊弹性测量检测肝、脾硬度可行性研究[J].中华超声影像学杂志,2019(07):617-620.
  37. 郑剑（第一作者）,曾婕,郑荣琴,吴涛,金洁玚,郭欢仪,黄泽萍,曾庆劲.二维剪切波弹性成像、瞬时弹性成像、实时组织弹性成像诊断肝纤维化的效能比较[J].中华医学超声杂志(电子版),2016,13(07):496-500.
  38. 郑荣琴,郑剑（第一作者）.剪切波弹性成像评价肝纤维化的现状与进展[J].中华医学超声杂志(电子版),2014,11(12):945-948.
  39. 郑剑（第一作者）,刘勇,郑荣琴,黄泽萍,曾婕,吴涛,曾庆劲.实时二维剪切波弹性成像与实时组织弹性成像评估慢性肝病肝纤维化的比较研究[J].中华超声影像学杂志,2014,23(11):944-947.
  40. 郑剑（第一作者）,杨丽新,吴涛,曾捷,黄泽萍,郑博文,张红君,郑荣琴.瞬时弹性成像与实时组织弹性成像评估肝纤维化的比较[J].中华肝脏病杂志,2014,22(10):731-734.
  41. 郑剑（第一作者）,曾婕,郑荣琴,黄泽萍,吴涛,曾庆劲,李凯,许尔蛟,苏中振.实时剪切波弹性成像与常规超声评估慢性乙型肝炎肝纤维化的比较[J].中华超声影像学杂志,2013,22(12):1036-1040.
  42. 郑剑（第一作者）,黄泽萍,郑荣琴,曾婕,任杰,郭欢仪,吴涛,曾庆劲.实时剪切波弹性成像技术与常规超声检查诊断肝硬化效能的比较[J].中华医学超声杂志(电子版),2013,10(12):1009-1012.
  43. 郑剑（第一作者）,曾婕,郑荣琴,黄泽萍,任杰,王丛知,郑海荣.检测深度对肝脏实时剪切波弹性成像的影响[J].中华医学超声杂志(电子版),2013,10(08):647-651.
  44. 郑剑（第一作者）,王平,尹庭辉,郑博文,程度,郑荣琴.机械振荡法与声振法制备纳米级微泡超声造影剂效能比较[J].中华超声影像学杂志,2012(12):1078-1081.
  45. 裴少华,郑剑,林沛杰,邹思源,何国枢,曾炜东,何可雄.物联网+超声远程智能会诊模式—罗湖医改形势下超声亚专科协作模式研究与配套软硬件初步探索[J].世界复合医学,2022,8(4):47-50.
  46. 裴少华,郑剑,黄晶,何可雄.不同超声下肾囊肿穿刺硬化术治疗肾囊肿的临床观察[J].影像技术,2021,33(03):26-30.
  47. 王青娟,郑剑,梁茜,李梁,康斯亮,贡雪灏.IOTA超声简易法则与卵巢肿瘤良恶性病理对照一致性分析研究[J].中国临床医学影像杂志,2021,32(04):277-280.
  48. 黄秀峰,郑剑,王青娟,曹君妍,梁茜,吴苏静,张新玲.膀胱截石位和分腿抱膝位膀胱颈移动度及肛提肌裂孔面积的比较[J].中华超声影像学杂志,2020,29(07):618-622.
  49. 金洁玚,郑玉宝,郑剑,郭欢仪,吴莉莉,高志良,郑荣琴.实时二维剪切波弹性成像评估慢加急性肝衰竭患者的预后[J].中山大学学报(医学科学版),2017,38(05):774-779.
  50. 曾婕,郑剑,黄泽萍,吴涛,郑荣琴.二维剪切波成像诊断慢性乙型肝炎肝纤维化不同取值方法的对比研究[J].中国超声医学杂志,2016,32(08):717-720.
  51. 聂红莲,郑剑,方北,李开林,那丽娟,张志刚,卢庆晖.超声评估早产儿动脉导管未闭对脑血流灌注影响的研究[J].临床超声医学杂志,2016,18(08):525-528.
  52. 聂红莲,方北,郑剑,李开林,那丽娟,张志刚,卢庆晖.高频彩超结合E-flow显像对早产儿早期脑血流灌注特点的观察[J].中国临床医学影像杂志,2016,27(06):381-384.
  53. 郭欢仪,杨丽新,曾婕,郑剑,吴涛,黄泽萍,郑荣琴.声学结构定量技术评价乙肝肝纤维化分期的价值[J].中山大学学报(医学科学版),2016,37(01):137-141.
  54. 张红君,郑剑,任杰,吴涛,郑博文,郑荣琴.二维剪切波弹性成像评估病毒性肝炎与非病毒性肝炎肝纤维化的效能比较[J].中华医学超声杂志(电子版),2015,12(03):218-222.
  55. 郭欢仪,黄泽萍,郑剑,曾婕,吴涛,张红君,郑荣琴.组织结构声学定量技术与剪切波弹性成像评价肝纤维化的比较[J].中华超声影像学杂志,2015,24(02):128-131.
  56. 郭欢仪,杨丽新,郑剑,曾婕,吴涛,黄泽萍,郑荣琴.慢性肝病患者剪切波弹性模量值的多因素回归分析[J].中国医学影像技术,2015,31(01):82-85.
  57. 曾庆劲,曾婕,吴涛,苏中振,郑剑,张红君,郑荣琴.剪切波弹性成像彩色图像评分法诊断良恶性乳腺实性病变[J].中国医学影像技术,2015,31(03):405-408.
  58. 黄泽萍,郑剑,郑荣琴,曾婕,吴涛.实时二维剪切波弹性成像评估健康人及慢性肝病患者肝脏硬度的重复性研究[J].中华医学超声杂志(电子版),2014,11(12):949-952.
  59. 黄泽萍,郑剑,郑荣琴,曾婕,贺需旗,吴涛.实时剪切波弹性成像检测正常成人肝的影响因素探讨[J].中华超声影像学杂志,2013(04):362-363.
  60. 黄泽萍,曾婕,郑荣琴,郑剑,吴涛,曾庆劲.实时剪切波弹性成像检测正常成人肝弹性模量正常值的研究[J].中华超声影像学杂志,2013(06):508-511.
  61. 李开林,郑剑,聂红莲.甲状腺癌的超声表现[J].临床超声医学杂志,2009,11(05):348-349.