Ph.D.  Sun Yat-Sen University of Medical Sciences

Professor Wang Lijuan graduated from Shanghai Medical University in 1985 and received her Ph.D. in neurology from Sun Yat-Sen University of Medical Sciences in 1996. Since 1999, she has served as the director of Neurology Department of Guangdong Provincial People's Hospital and Guangdong Neuroscience Institute. In 2006, she visited the University of British Columbia Neuroscience Department as a visiting professor. Now professor Wang is appointed as the vice Chairman of Neurological Committee of Chinese Medical Doctor Association and deputy leader of Parkinson's Disease and Movement Disorders group of Neurological Committee of Chinese Medical Doctor Association and Chinese Medical Association. She is the deputy chairman of Mobile Medical Subcommittee in Chinese Stroke Society and the chairman of Guangdong-Hong Kong-Macao Greater Bay Area Neurologist Alliance. She also serves as the executive member of the Council and the Chairman of Neurological Committee of Guangdong Medical Doctor Association. Her research interests focus on the clinical, neuropsychological, functional imaging, molecular and vascular mechanisms of Parkinson's disease, cerebrovascular disease, and cognitive impairment (including Alzheimer's disease). As the project leader, She has undertaken and completed more than 20 research projects including National Major R & D Program “Major chronic disease” of China, National Natural Science Foundation of China, as well as Guangdong Natural Science Foundation, Guangdong and Guangzhou Key Science and Technology Project. She spearheaded the writing and participated in expert consensus on diagnosis and treatment of vascular parkinsonism, Parkinson's disease, and other movement disorders in China. She has published more than 100 articles in peer reviewed international journals (e.g. "Parkinsonism & Related Disorders", "Stroke", "Neurobiology of Aging") and core domestic journals. She was granted 5 national patents and applied for 3 invention patents. She is the recipient of Science and Technology Progress Awards issued by the State Council, the Ministry of Health, the Ministry of Education of the People's Republic of China and Guangdong Provincial People's Government.

Selected Publication:
1. Wang, W.Y., Mei, M.J., Gao, Y.Y., Huang, B., Qiu, Y.H., Zhang, Y.H., Wang, L.M., Zhao, J.H., Huang, Z.H., Wang, L.J., and Nie, K. (2020). Changes of brain structural network connection in Parkinson's disease patients with mild cognitive dysfunction: a study based on diffusion tensor imaging. J. Neurol. 267:933-943. PMID:31792673
2. Ren, T.Z., Gao, Y.Y., Qiu, Y.H., Jiang, S.L., Zhang, Q.X., Zhang, J.H., Wang, L.M., Zhang, Y.H., Wang, L.J., and Nie, K. (2020). Gut Microbiota Altered in Mild Cognitive Impairment Compared With Normal Cognition in Sporadic Parkinson's Disease. Front. Neurol. 11:137. PMID:32161568
3. Gao, Y.Y., Tang, H.M., Nie, K., Zhu, R.M., Gao, L., Feng, S.J., Wang, L.M., Zhao, J.H., Huang, Z.H., Zhang, Y.H., and Wang, L.J. (2019). Hippocampal damage and white matter lesions contribute to cognitive impairment in MPTP-lesioned mice with chronic cerebral hypoperfusion. Behav. Brain. Res. 368:111885. PMID: 30959125
4. Li, S.Y., Nie, K., Zhang, Q.X., Guo, M.L., Qiu, Y.H., Li, Y., Gao, Y.Y., and Wang, L.J. (2019). Macrophage Migration Inhibitory Factor Mediates Neuroprotective Effects by Regulating Inflammation, Apoptosis and Autophagy in Parkinson's Disease. Neuroscience. 416:50-62. PMID: 31170483
5. Zhang, S., Zhao, J.H., Zhang, Y.H., Zhang, Y., Cai, F., Wang, L.J., and Song, W.H. (2019). Upregulation of MIF as a defense mechanism and a biomarker of Alzheimer's disease. Alzheimers. Res. Ther. 11:54. PMID: 31174614
6. Gao, Y.Y., Nie, K., Mei, M.J., Guo, M.L., Huang, Z.H., Wang, L.M., Zhao, J.H., Huang, B., Zhang, Y.H., and Wang, L.J. (2018). Changes in Cortical Thickness in Patients With Early Parkinson's Disease at Different Hoehn and Yahr Stages. Front. Hum. Neurosci. 12:469. PMID: 30542273
7. Wang, L., Nie, K., Zhao, X., Feng, S.J., Xie, S.F., He, X.T., Ma, G.X., Wang, L.M., Huang, Z.H., Huang, B., Zhang, Y.H., and Wang, L.J. (2018). Characteristics of gray matter morphological change in Parkinson's disease patients with semantic abstract reasoning deficits. Neurosci. Lett. 673:85-91. PMID: 29275185
8. Zhang, G.H., Zhang, C.G., Zhang, Y.H., Wang, Y.K., Nie, K., Zhang, B., Xie, H.Q., Lu, J.C., and Wang, L.J. (2017). The effects of striatal silent lacunar infarction on the substantia nigra and movement disorders in Parkinson's disease: A follow-up study. Parkinsonism. Relat. Disord. 43:33-37. PMID: 28688982
9. Huang, J., Zhuo, W.Y., Zhang, Y.H., Sun, H.C., Chen, H., Zhu, P.P., Pan, X.B., Yang, J.H., and Wang, L.J. (2017). Cognitive Function Characteristics of Parkinson's Disease with Sleep Disorders. Parkinsons. Dis. 2017: 4267353. PMID: 28484661
10. Tang, H.M., Gao, Y.Y., Zhang, Q.X., Nie, K., Zhu, R.M., Gao, L., Feng, S.J., Wang, L.M., Zhao, J.H., Huang, Z.H., Zhang, Y.H., and Wang, L.J. (2017). Chronic cerebral hypoperfusion independently exacerbates cognitive impairment within the pathopoiesis of Parkinson's disease via microvascular pathologys. Behav. Brain. Res. 333: 286-294. PMID: 28578987
11. Gao, Y.Y., Nie, K., Huang, B., Mei, M.J., Guo, M.L., Xie, S.F., Huang, Z.H., Wang, L.M., Zhao, J.H., Zhang, Y.H., and Wang, L.J. (2017). Changes of brain structure in Parkinson's disease patients with mild cognitive impairment analyzed via VBM technology. Neurosci. Lett. 658:121-132. PMID: 28823894
12. Nie. K., Feng, S.J., Tang, H.M., Ma, G.X., Gan, R., Zhao, X., Zhao, J.H., Wang, L.M., Huang, Z.H., Huang, J., Gao, L., Zhang, Y.W., Zhu, R.M., Duan, Z.P., Zhang, Y.H., and Wang, L.J. (2015). RIT2 polymorphism is associated with Parkinson’s disease in a Han Chinese population. Neurobiol. Aging. 36: 1603.e15-17. PMID: 25457028
13. Feng, S.J., Nie, K., Gan, R., Huang, J., Zhang, Y.W., Wang, L.M., Zhao, J.H., Tang, H.M., Gao, L., Zhu, R.M., Duan, Z.P., Zhang, Y.H., and Wang, L.J. (2014). Triggering receptor expressed on myeloid cells 2 variants are rare in Parkinson's disease in a Han Chinese cohort. Neurobiol. Aging. 35: 1780.e11-12. PMID: 24602511
14. Nie, K., Zhang, Y.H., Huang, B., Wang, L.M., Zhao, J.H., Huang, Z.H., Gan, R., and Wang, L.J. (2013). Marked N-acetylaspartate and choline metabolite changes in Parkinson’s disease patients with mild cognitive impairment. Parkinsonism. Relat. Disord. 19: 329-334. PMID: 23238068
15. Wang, L.J., Zis, O., Ma, G.X., Shan, Z.X., Zhang, X., Wang, S., Dai, C.B., Zhao, J.H., Lin, Q.X., Lin, S.G., and Song, W.H. (2009). Upregulation of macrophage migration inhibitory factor gene expression in stroke. Stroke. 40: 973-976. PMID: 19131653