Ph.D. (Nanjing University)

M.S. (The University of Akron)

BSc. (Nanjing University)

Professor Sun is a professor at the Warshel Institute of Computational Biology at The CUHK-Shenzhen School of MEDICINE. He completed his Ph.D. at Nanjing University in 1998, M.S. in Computer Science from The University of Akron, USA, in 2002. His career includes pivotal roles as Research Scientist/Adjunct Assistant Professor at the Department of Molecular Virology, Immunology, and Medical Genetics of the Ohio State University Medical Center (2001-2008), Co-Director of the Bioinformatics Core Facility and Wistar Scientist at The Wistar Institute, Philadelphia, USA (2008-2009). In 2009, he joined The Chinese University of Hong Kong as assistant professor at the Li Ka Shing Institute of Health Sciences and the Department of Chemical Pathology, where he also served as the director of the Biomedical Computing Centre.

Prof. Sun’s research is focusing on understanding the noncoding RNA discovery and functional characterization in muscle stem cells, developing bioinformatics algorithms for noninvasive genetic diagnosis, and discovering new biomarkers based on high-throughput sequencing data. He served as associate and academic editor for the Journal of Clinical Biochemtry, and PLoS ONE respectively. Over the years, Prof. Sun has received a number of research awards from a variety of funding schemes supported by the Hong Kong SAR and mainland of China government, such as General Research Fund (RGC/GRF), Areas of Excellence Scheme (AoE), and Theme-based Research Scheme (TRS) from Hong Kong government, as well as NSFC-RGC joint grant supported from both Hong Kong and mainland of China. He has published over 130 peer-reviewed publications with more than 12,000 citations, mostly in prestigious journals, including Cell, Cancer Cell, Molecular Cell, Science of Translational Medicine, Nature Medicine, Nature Communications, Genome Research, and Nucleic Acids Research. Prof. Sun’s Lab is open for applications from interested postdoctoral fellows, PhD and master degree students, and undergraduate exchange students.

Google Scholar:

https://scholar.google.com/citations?user=nFPk7EkAAAAJ&hl=en

1. Lin Y, Zhang Y, Sun H, Jiang H, Zhao X, Teng X, Lin J, Shu B, Sun H, Liao Y, Zhou J. NanoDeep: a deep learning framework for nanopore adaptive sampling on microbial sequencing. Brief Bioinform. 2023;25(1):bbad499. doi: 10.1093/bib/bbad499.
2. Zhang S, Yang F, Huang Y, He L, Li Y, Wan YCE, Ding Y, Chan KM, Xie T, Sun H, Wang H. ATF3 induction prevents precocious activation of skeletal muscle stem cell by regulating H2B expression. Nat Commun. 2023;14(1):4978. doi: 10.1038/s41467-023-40465-w.
3. Zhao Y, Ding Y, He L, Zhou Q, Chen X, Li Y, Alfonsi MV, Wu Z, Sun H, Wang H. Multiscale 3D genome reorganization during skeletal muscle stem cell lineage progression and aging. Sci Adv. 2023 Feb 17;9(7):eabo1360. doi: 10.1126/sciadv.abo1360.
4. Qiao Y, Sun Q, Chen X, He L, Wang D, Su R, Xue Y, Sun H, Wang H. Nuclear m6A reader YTHDC1 promotes muscle stem cell activation/proliferation by regulating mRNA splicing and nuclear export. Elife. 2023;12:e82703. doi: 10.7554/eLife.82703.
5. So KKH, Huang Y, Zhang S, Qiao Y, He L, Li Y, Chen X, Sham MH, Sun H, Wang H. seRNA PAM controls skeletal muscle satellite cell proliferation and aging through trans regulation of Timp2 expression synergistically with Ddx5. Aging Cell. 2022;21(8):e13673. doi: 10.1111/acel.13673.
6. Liang C, Ke Q, Liu Z, Ren J, Zhang W, Hu J, Wang Z, Chen H, Xia K, Lai X, Wang Q, Yang K, Li W, Wu Z, Wang C, Yan H, Jiang X, Ji Z, Ma M, Long X, Wang S, Wang H, Sun H, Belmonte JCI, Qu J, Xiang AP, Liu GH. BMAL1 moonlighting as a gatekeeper for LINE1 repression and cellular senescence in primates. Nucleic Acids Res. 2022;50(6):3323-3347. doi: 10.1093/nar/gkac146.
7. Chen X, Yuan J, Xue G, Campanario S, Wang D, Wang W, Mou X, Liew SW, Umar MI, Isern J, Zhao Y, He L, Li Y, Mann CJ, Yu X, Wang L, Perdiguero E, Chen W, Xue Y, Nagamine Y, Kwok CK, Sun H, Muñoz-Cánoves P, Wang H. Translational control by DHX36 binding to 5'UTR G-quadruplex is essential for muscle stem-cell regenerative functions. Nat Commun. 2021;12(1):5043. doi: 10.1038/s41467-021-25170-w.
8. Huang Y, Qiao Y, Zhao Y, Li Y, Yuan J, Zhou J, Sun H, Wang H. Large scale RNA-binding proteins/LncRNAs interaction analysis to uncover lncRNA nuclear localization mechanisms. Brief Bioinform. 2021;22(6):bbab195. doi: 10.1093/bib/bbab195.
9. Zheng Q, Li G, Wang S, Zhou Y, Liu K, Gao Y, Zhou Y, Zheng L, Zhu L, Deng Q, Wu M, Di A, Zhang L, Zhao Y, Zhang H, Sun H, Dong C, Xu H, Wang X. Trisomy 21-induced dysregulation of microglial homeostasis in Alzheimer's brains is mediated by USP25. Sci Adv. 2021;7(1):eabe1340. doi: 10.1126/sciadv.abe1340.
10. He L, Ding Y, Zhao Y, So KK, Peng XL, Li Y, Yuan J, He Z, Chen X, Sun H, Wang H. CRISPR/Cas9/AAV9-mediated in vivo editing identifies MYC regulation of 3D genome in skeletal muscle stem cell. Stem Cell Reports. 2021;16(10):2442-2458. doi: 10.1016/j.stemcr.2021.08.011.
11. Sun X, Ren Z, Cun Y, Zhao C, Huang X, Zhou J, Hu R, Su X, Ji L, Li P, Mak KLK, Gao F, Yang Y, Xu H, Ding J, Cao N, Li S, Zhang W, Lan P, Sun H, Wang J, Yuan P. Hippo-YAP signaling controls lineage differentiation of mouse embryonic stem cells through modulating the formation of super-enhancers. Nucleic Acids Res. 2020;48(13):7182-7196. doi: 10.1093/nar/gkaa482.
12. Li Y, Yuan J, Chen F, Zhang S, Zhao Y, Chen X, Lu L, Zhou L, Chu CY, Sun H, Wang H. Long noncoding RNA SAM promotes myoblast proliferation through stabilizing Sugt1 and facilitating kinetochore assembly. Nat Commun. 2020;11(1):2725. doi: 10.1038/s41467-020-16553-6.
13. Sun K, Jiang P, Cheng SH, Cheng THT, Wong J, Wong VWS, Ng SSM, Ma BBY, Leung TY, Chan SL, Mok TSK, Lai PBS, Chan HLY, Sun H, Chan KCA, Chiu RWK, Lo YMD. Orientation-aware plasma cell-free DNA fragmentation analysis in open chromatin regions informs tissue of origin. Genome Res. 2019;29(3):418-427. doi: 10.1101/gr.242719.118.
14. Bao X, Guo X, Yin M, Tariq M, Lai Y, Kanwal S, Zhou J, Li N, Lv Y, Pulido-Quetglas C, Wang X, Ji L, Khan MJ, Zhu X, Luo Z, Shao C, Lim DH, Liu X, Li N, Wang W, He M, Liu YL, Ward C, Wang T, Zhang G, Wang D, Yang J, Chen Y, Zhang C, Jauch R, Yang YG, Wang Y, Qin B, Anko ML, Hutchins AP, Sun H, Wang H, Fu XD, Zhang B, Esteban MA. Capturing the interactome of newly transcribed RNA. Nat Methods. 2018;15(3):213-220. doi: 10.1038/nmeth.4595.
15. Zhao Y, Sun H, Wang H. Long noncoding RNAs in DNA methylation: new players stepping into the old game. Cell Biosci. 2016;6:45. doi: 10.1186/s13578-016-0109-3.
16. Jiang P, Sun K, Lun FM, Guo AM, Wang H, Chan KC, Chiu RW, Lo YM, Sun H. Methy-Pipe: an integrated bioinformatics pipeline for whole genome bisulfite sequencing data analysis. PLoS One. 2014;9(6):e100360. doi: 10.1371/journal.pone.0100360.
17. Yu SC, Chan KC, Zheng YW, Jiang P, Liao GJ, Sun H, Akolekar R, Leung TY, Go AT, van Vugt JM, Minekawa R, Oudejans CB, Nicolaides KH, Chiu RW, Lo YM. Size-based molecular diagnostics using plasma DNA for noninvasive prenatal testing. Proc Natl Acad Sci U S A. 2014;111(23):8583-8. doi: 10.1073/pnas.1406103111.
18. Chan KC, Jiang P, Zheng YW, Liao GJ, Sun H, Wong J, Siu SS, Chan WC, Chan SL, Chan AT, Lai PB, Chiu RW, Lo YM. Cancer genome scanning in plasma: detection of tumor-associated copy number aberrations, single-nucleotide variants, and tumoral heterogeneity by massively parallel sequencing. Clin Chem. 2013;59(1):211-24. doi: 10.1373/clinchem.2012.196014.
19. Chiu RW, Akolekar R, Zheng YW, Leung TY, Sun H, Chan KC, Lun FM, Go AT, Lau ET, To WW, Leung WC, Tang RY, Au-Yeung SK, Lam H, Kung YY, Zhang X, van Vugt JM, Minekawa R, Tang MH, Wang J, Oudejans CB, Lau TK, Nicolaides KH, Lo YM. Non-invasive prenatal assessment of trisomy 21 by multiplexed maternal plasma DNA sequencing: large scale validity study. BMJ. 2011;342:c7401. doi: 10.1136/bmj.c7401. PMID: 21224326; PMCID: PMC3019239.
20. Lo YM, Chan KC, Sun H, Chen EZ, Jiang P, Lun FM, Zheng YW, Leung TY, Lau TK, Cantor CR, Chiu RW. Maternal plasma DNA sequencing reveals the genome-wide genetic and mutational profile of the fetus. Sci Transl Med. 2010 Dec 8;2(61):61ra91. doi: 10.1126/scitranslmed.3001720.