The conformation of proteins can be analyzed using amide hydrogen exchange (HDX) mass spectrometry, which allows the analysis of protein dynamics, protein-protein interaction interfaces, ligand-induced allosteric conformational changes and protein stability studies. HDX data can be obtained from samples that are available in small amounts, and can complement high resolution methods as Cryo-EM and X-ray crystallography.

Our total HDX platform covers the complete process from sample labeling and optimization of digestion conditions to optimizing mass spec utilization and data curation. Automation allows for complete control of all key factors: reproducible accuracy in timing of liquid transfers, pH control and temperature control and in-line digestion.