During native MS, noncovalent interactions between proteins and their ligands, for example, other proteins, nucleotides, lipids, metals or other small molecules, are maintained. The obtained mass spectra therefore reveal the subunit composition and stoichiometry of the formed complexes.

Native MS further provides information on protein-ligand interactions including drug conjugates, subunit interactions and topology as well as heterogeneity of the assemblies. The High Mass Range MSⁿ capability allows for identification of ligands bound to both cytosolic and membrane proteins.

Please contact us to discuss sample requirements and advanced applications such high-resolution native MS and characterization of native protein-ligand complexes. Native MS service is offered only in a collaborative setting.