Identification of post-translational modifications on proteins e.g. phosphorylation, acetylation, methylation, lipidation, ubiquitination, glycosylation, cysteine redox state.  We can perform site localisation and stoichiometry of post-translational modifications or chemical modifications on proteins from pure samples e.g. purified protein/protein complex and complex mixtures e.g. proteins extracted from cell line/tissue.

For complex mixtures e.g. proteins extracted from cell line/tissue or sub-stoichiometrically modified samples we can perform enrichment of the modification prior to analysis. We use MOAC columns packed with TiO₂ for phosphopeptide enrichment.