You are cordially invited to join the Frontiers in Medical Research Seminar, to be delivered by Prof. Da Mi on November 7, 2025 (Friday). The lectures are entitled 'Emergence of Inhibitory Neuron Diversity in the Mammalian Cerebral Cortex'. Please note that the language of this lecture is Chinese.

Please find the details as follows:

Date: November 7, 2025 (Friday)

Time: 10:45 am -12:00 pm

Venue: Teaching D Building 103 (TD103)

Speakers: Prof. Da Mi

Host: Dr. Limin Xu

About the Speaker:

Dr. Da Mi is an expert in developmental neuroscience. He has been appointed as an Associate Professor in the School of Life Sciences, Tsinghua University and a group leader at the Center for Life Sciences (CLS) and the IDG/McGovern Institute for Brain Research at Tsinghua University. His team combines large-scale single-cell multi-omics techniques with a range of neuroanatomical, cell biological, molecular biological, genetic and transgenic methods to gain systematic understanding of the cellular and molecular mechanisms regulating initial cell fate decisions and neuronal diversification in the developing cerebral cortex in rodents, non-human primates and human and the role of cellular heterogeneity in neurodevelopmental disorders.

Abstract:

The human cerebrum has an extensive and diverse complement of inhibitory neurons (INs), which may contribute to the heightened cognitive capability of our species. However, the mechanisms underlying the generation of the vast repertoire of human INs remain elusive. We performed spatial and single-cell transcriptomics of human medial ganglionic eminence (hMGE), a pivotal source of INs destined for the cerebral cortex and subpallium, to build the developmental trajectories of MGE-derived cells throughout pregnancy. We identified spatiotemporally and molecularly segregated progenitor cell populations fated to produce distinct types of INs. Notably, we found a novel progenitor cell type in the hMGE subventricular zone (SVZ RGCs) with unique molecular and cellular features. We demonstrated that SVZ RGCs maintained the production of INs and glial cells throughout human brain development. Our findings reveal evolutionarily distinct features of IN generation and shed light on the unique mechanisms underlying human brain development.

Please fill in the Registration Form by clicking this link https://v.wjx.cn/vm/tZf4gCA.aspx# .